摘要:

In female rats, pretreatment with pregnenolone-16α-carbonitrile (PCN), spironolactone or CS-11 reduced the toxicity of sulfadiazine; the first two steroids also decreased its concentrations in plasma. Prednisolone acetate, triamcinolone, estradiol and thyroxine increased mortality. The levels of sulfadiazine in plasma were elevated by triamcinolone and not significantly altered by ACTH. Phenobarbital failed to protect or sensitize. Apparently, the steroids (and ACTH) affect resistance through different biochemical mechanisms

ISSN:0031-7012    

DOI:10.1159/000136506

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Data are presented suggesting that alteration of hepatic microsomal metabolism of the mouse by malathion is associated with the ability of this insecticide to bind to or alter cytochrome P-450 content. Malathion is shown to bind to the reduced form of cytochrome P-450.

ISSN:0031-7012    

DOI:10.1159/000136507

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The effects of i.v. injections of 0.05 mM (20 mg)/kg potassium canrenoate and equimolar (3.75 mg/kg) potassium chloride on ventricular tachycardia (VT) and ventricular fibrillation (VF) induced by i.v. infusion of ouabain (2 µg·kg-1 • min-1) were studied in 46 rabbits anesthetized with sodium pentobarbital. Ventricular tachycardia occurred after a mean dose of 110µg of ouabain in 32 rabbits divided into three groups: eight control rabbits received no treatment after the onset of VT, 18 received potassium canrenoate and six received potassium chloride. Within 1 min following the first injection of potassium canrenoate, VT was converted into sinus rhythm in each of the 18 rabbits; however, in 11 rabbits additional injections of the drug were necessary to achieve a sustained conversion. Potassium chloride injections failed to convert VT in the six rabbits so treated. Ventricular fibrillation was induced in 14 rabbits after a mean dose of 160 µg of ouabain. Even VF could be converted into sinus rhythm by potassium canrenoate in four of eight rabbits. Equimolar potassium chloride treatment had no effect on VF in the remaining six rabbits. These data further demonstrated the effectiveness of canrenoate in experimental dysrhythmias induced by ou

ISSN:0031-7012    

DOI:10.1159/000136508

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The effect of Intralipid®, Lipofundin®, and Triton WR 1339, was studied on various models of acute inflammation. It was found that in CFY rats these agents inhibited the foot edema induced by dextran, 5-HT, carrageenin, and formalin, as well as turpentine pleurisy. Thermic edema was not influenced. The anti-inflammatory activity depended on the dose and roughly paralleled the elevation of the serum triglyceride level. FFA concentration did not seem to be an important factor in the development of the anti-inflammatory effect. Oleic acid and glycerol administered through a stomach tube had no effect on dextran inflammation, while sunflower seed oil and pig fat produced a dose-related blocking effect. Increased vascular permeability induced by dextran, compound 48/80, histamine, and 5-HT was also suppressed by Intralipid® and Triton WR 1339. Triton produced its pronounced anti-inflammatory effect only 24 h after the administration, when an extreme hypertriglyceridemia developed. Adrenalectomy did not prevent the anti-inflammatory activity. The possible significance of the findings obtained is discuss

ISSN:0031-7012    

DOI:10.1159/000136509

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A new hypnotic drug, flurazepam, was given to six healthy young men in a blind trial involving sleep on four consecutive nights in the laboratory. Continuous recordings of the electro-encephalogram, electro-oculogram and electrical resistance of palmar skin made throughout the night enabled sleep to be analyzed objectively in terms of the usual stages. Sleep on the third night, when flurazepam 15 mg was taken, was compared with that on the second and fourth nights, when a placebo was taken. Flurazepam permitted sleep which was objectively better and subjectively as good as the best sleep without the drug. There was no inhibition either of REM-sleep or of δ-wave sleep as occurs with many other hypnotics

ISSN:0031-7012    

DOI:10.1159/000136510

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0031-7012    

DOI:10.1159/000135504

出版商:S. Karger AG    

年代:1964

数据来源: Karger

摘要:

Experiments measuring hepatic choline uptake in the isolated perfused liver have demonstrated that phenobarbital inhibits this mechanism by 50 %. This inhibition was found to be dose dependent in a linear manner and the presence of the drug was found to be required to produce the effect. However, pretreatment of animals with phenobarbital had little influence. Hepatic choline uptake is believed to be mostly regulated by choline oxidation. Experiments measuring the direct oxidation of choline by the liver showed that Phenobarbital inhibits this oxidation, hence its possible effect on choline uptake.

ISSN:0031-7012    

DOI:10.1159/000136511

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0031-7012    

DOI:10.1159/000135505

出版商:S. Karger AG    

年代:1964

数据来源: Karger

ISSN:0031-7012    

DOI:10.1159/000136512

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0031-7012    

DOI:10.1159/000136513

出版商:S. Karger AG    

年代:1974

数据来源: Karger