摘要:

Histological studies in male C 57 black mice revealed a high incidence (39–61 %) of osteo-arthrotic changes in the knee joint from about the 17th month of life. In animals of the same strain aged 15½ months the incidence was only 19 %. The incidence of gonarthroses in 16-month-old female mice was considerably lower (4 %). In male mice aged 17–20 months, the oral administration of tribenoside in doses of 500 and 1,200 mg/kg weekly led to a significant (p < 0.05) reduction in the overall arthrotic involvement. A possible relation between the effect of tribenoside and other anti-inflammatory agents on osteo-arthroses in the mouse and their influence on mucopolysaccharide metabolism in connective tissue is discussed. The incidence of the formation of gaps in the epiphyseal growth zones and of osteoporosis of the femur and tibia in the same strain increases distinctly with advancing age. Except in animals treated with the highest dosage tested, in which there was a significant decrease in the development of osteoporosis, tribenoside in the range of doses used had no influence on these skeletal cha

ISSN:0031-7012    

DOI:10.1159/000136607

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

In our previous work we examined the mechanism of action of the new tremorogenic substance verruculogen isolated by Cole and coworkers. Examining the effect of various substances with known mechanisms of action on verruculogen-induced tremor, we concluded that this tremor was probably related to decrease of GABA levels in CNS. In order to further define the mechanisms of action of verruculogen, we determined brain GABA levels in animals in which tremor was produced by verruculogen administration. Verruculogen administration produced a decrease in GABA levels in mouse CNS. This finding substantiates our earlier suggestion that verruculogen-induced tremor is mediated by a loss of inhibitory GABA function.

ISSN:0031-7012    

DOI:10.1159/000136608

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Among the available antidotes used against parathion poisoning, atropine and Buscopan® are tolerated in relatively high doses by rats. Hyoscine (in very small doses), T. Bel. Alk. and T. Hyosc. Alk. (better results in small doses, also for dogs), P2AM (of superior antimuscarine action) are recommended with each of the preceding drugs than either alone or in combination with Buscopan

ISSN:0031-7012    

DOI:10.1159/000136609

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Δ9-Tetrahydrocannabinol (THC) elicited a dose-dependent (3.2–24 μM) response for form/movement, cellular growth and division in log growth phase and division-synchronized Tetrahymena pyriformis GL. Progressive dose-dependent action of THC on division delays in division-synchronized cell cultures was correlated with a concomitant reduction of division maxima and the percent of cells that completed division I. THC depressed the incorporation of 5-3H-uridine, 2-14C-thymidine and L-3-14C-phenylalanine into RNA, DNA and protein macromolecules respectively of division-synchronized Tetrahymena during division I, The depression of incorporation of 5-3H-uridine into nucleic acid macromolecules was correlated with a reduction of exogeneous precursor in the cellular pool. The specific activity of radiolabeled mRNA and nascent polypeptides of polyribosomal fractions from synchronized cells was reduced by THC treatment. THC caused an inhibition of the incorporation of 5-3H-uridine into ribosomal RNA (17S and 25S RNA) and ribosomal precursor RNA (35S RNA) of synchronized ce

ISSN:0031-7012    

DOI:10.1159/000136610

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0031-7012    

DOI:10.1159/000135802

出版商:S. Karger AG    

年代:1966

数据来源: Karger

摘要:

The serum titer of interferon produced by polyinosinic:polycytidylic acid (poly I:C) was studied in mice following subcutaneous injections of either morphine alone, naloxone alone, morphine and naloxone together, morphine preceded by naloxone, naloxone preceded by morphine, or a sequence of injections of naloxone, morphine, and naloxone again. Poly I:C injected without the other drugs present served as the control. Both morphine and naloxone produced a significant decrease in the ability of the mice to increase the serum titer of interferon in response to poly I:C. Naloxone appeared to function as an antagonist to morphine when administered following the morphine injection, but not when injected before or simultaneously with the opiate. When naloxone was injected both before and following the morphine injection, results were interpreted to indicate the possibility that naloxone could function as both an agonist and antagonist under this condition.

ISSN:0031-7012    

DOI:10.1159/000136611

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

This study has examined uptake, efflux and metabolism of 14C-histamine by vascular smooth muscle. 14C space in aortae reached 4.3 ± 0.14 ml/g (mean ± SE) after 1 h exposure to 14C-histamine (2 μM) in Tyrode’s solution. Aminoguanidine (10–5M) and non-radioactive histamine (10–4 and 10–3M) significantly reduced 14C space. Efflux experiments were performed on aortic strips exposed to 14C-histamine for 1 h. The rate of loss of radioactivity was not enhanced by nonradioactive histamine or compound 48/80. It appears that 14C-histamine was not accumulated and bound in mast cells in this tissue. After 1 h exposure to 14 C-histamine, labeled material was extracted from tissues for identification of metabolites by paper chromatography. About 40 % of the label was 14C-histamine, and the remainder was primarily imidazole acetic acid. After exposure to aminoguanidine, an inhibitor of diamine oxidase, about 80 % of the label was 14C-histamine. These data suggest that oxidative deamination is the primary catabolic route for histamine in ra

ISSN:0031-7012    

DOI:10.1159/000136612

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0031-7012    

DOI:10.1159/000135803

出版商:S. Karger AG    

年代:1966

数据来源: Karger

ISSN:0031-7012    

DOI:10.1159/000135804

出版商:S. Karger AG    

年代:1966

数据来源: Karger

ISSN:0031-7012    

DOI:10.1159/000135805

出版商:S. Karger AG    

年代:1966

数据来源: Karger