摘要:

SummaryArterial hypertension is a very common disease, and one of the main causes of death in our countries. In the early stages, this disease is completely asymptomatic and thus the diagnosis can only be made by systematic examinations.How to treat, it is a problem which can only be solved if a certain amount of information is obtained. The physician must find out if other risk factors of atherosclerosis are involved: hypercholesterolemia, diabetes, cigarette smoking, etc. He must also look for complications of high blood pressure with respect to the heart, the kidneys, the arteries and the brain. All these parameters may affect the decision and the choice of the treatment.The first step of treatment must be the research for curable causes of hypertension. However, from data obtained during the last few years, we know that surgical causes of hypertension are unusual: less than 10% of the patients in a reference centre. In most of the case, the patient should be treated with drugs.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717096

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717095

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryHigh blood pressure has a deleterious effect on the kidney. It significantly modifies renal handling of water and electrolytes partially, at least, as a result of haemodynamic changes in the kidney. These disorders, which are observed only under conditions of maximal stimulation, are of little interest to the clinician.Hypertension ultimately accelerates the ageing process of the kidney resulting in benign nephrosclerosis. This latter condition is not usually a cause of severe renal failure.Severe elevation of blood pressure occasionally induces malignant hypertension. This condition is characterized by necrotizing angeitis associated with subacute renal failure. Prompt and efficient hypotensive therapy may prevent or stabilize renal insufficiency. In a few cases, a return of normal renal function has been observed despite initial acute renal failure. The prognosis of malignant hypertension is determined largely by th2 degree of renal insufficien cy prevailing when hypotensive therapy is started. At first, lowering blood pressure may decrease glomerular filtration rate. In the long run, however, renal function improves.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717098

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryThe systemic arterial pressure is determined by 1) the cardiac output, 2) the blood volume, and 3) the total peripheral resistance.A triple antihypertensive therapy is therefore considered which interferes primarily with these three factors using 1) beta adrenergic blocking agents, 2) a low sodium diet and diuretics, and 3) vasodilating antihypertensive drugs. The hae-modynamic changes during this therapy are described.Since cardiac output, resistance and blood volume cannot be determined routinely in all hypertensive patients, a therapeutic regimen is discussed based on the determination of 1) rate, 2) body weight and 3) arterial blood pressure.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717099

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryA total of 662 patients with mild to moderate essential hypertension were enrolled in four types of studies: (a) timolol maleate. thrce-times-a-day, (b) timolol maleate twice-a-day, (c) a combination of timolol maleate/hydrochlorothiazide and (d) a combination of timolol maleate/hydro-chlorothiazide/amiloride. The results of these studies indicated that timolol maleate used 3 or 2 times a day has a significantly greater antihypertensive activity than placebo, and that the combination of therapy with either timolol maleate/hydrochlorothiazide or timolol male-ate/hydrochlorothiazide/amiloride had a greater antihypertensive effect than each of its components.At the dose used, timolol maleate alone or in combination with hydrochlorothiazide, with or without amiloride, was a well tolerated antihypertensive agent.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717100

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryTwo recent publications have demonstrated that, in the United States, most hypertensive patients are lost to treatment by 5 years. This high percentage of abandonment is not caused by side effects of the prescribed therapy; most patients claimed they stopped the treatment because they were not correctly informed about the nature of their disease and the way the treatment had to be carried out. The frequency of drop-out may be markedly decreased if the hypertensive patient or his family has a good understanding of the disease, and correct information about the treatment and the expected results, as well as the possible side effects.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717101

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryMitral endocarditis with Streptococcus viridans in a female patient aged 61 years, complicates with a disseminated intravascular coagulopathy, finally with an embol of the aortic bifurcation.A relationship between these three phenome-nons is suggested.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717102

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717103

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717104

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717105

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor