摘要:

Discussion and SummaryAnti-GBM autoimmunity can be detected by various tests usable for clinical purposes : immunofluorescence, passive hemagglutination, radioimmunoassay and inhibition of leucocytes migration. Positive results are registered in about 5 to 10 percent of nephrological diseases.Interpretation of those results varies according to the individual cases :1. High affinity anti-GBM antibodies found in serum of patients suffering from Goodpasture Syndrome are indeed responsible for the glomerular nephritis and react with the kidneys and lungs. A possible pathogenic role of lymphocytes sensitized with GBM is still questionnable.2. Circulating anti-GBM antibodies and reactions of cellular immunity observed in renal diseases with major vascular lesions appear secondarily to renal necrosis.3. Anti-GBM antibodies found in proliferative glomerulonephritis exhibit a moderate affinity for the basal membrane antigenic determinants. Their pathogenic role has been demonstrated in glomerulonephritis with linear deposits only.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716890

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716891

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryA review of metabolic bone diseases is given based on personnel experience. Part one deals with radiological aspects. Morphological aspects rather than subjective appreciation of density is emphasized. Results obtained in cases suffering from osteoporosis are reported, compared to normal values matched for age and sex. The techniques used were : radiogrammetry of cortical bone at the hand skeleton, trabecular pattern at the femoral neck and photon absorption technique for the estimation of mineral content.In part two clinical tests commonly used in the exploration of metabolic bone diseases are summarized. In addition to biochemical tests the usefullness of histology and kinetic studies are given.In part three a comparative study of biochemical exploration of 93 metabolic bone diseases is reported.The following diseases were studied : osteoporosis, osteomalacia, myeloma, hyperparathyroidism, Paget’s disease and acromegaly.In young male patients with osteoporosis some characteristics suggesting hyperparathyroidism were found.The effect of anticonvulsive drugs on serum calcium, phosphor, alkaline phosphatase and bicarbonate in 80 epileptics is reported. Significant changes have been found, indicating a disturbance in vitamin D metabolism.Recent advances in therapy for osteoporosis, osteomalacia and Paget’s disease in connection with recent physiopathological knowledge of these diseases are reported in part four.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716892

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryThe analysis of 66 tissue samples obtained from 57 kidney grafts shows good correlation between the immune deposits observed in immunofluorescence and the histologic lesions of rejection. The high incidence of fibrinogen deposits demonstrates the importance of intravascular coagulation in the pathogenesis of graft destruction.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716893

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716894

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor