ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718513

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryBurkholderia cepaciahas become an increasingly recognized pathogen among cystic fibrosis (CF) patients and its potential role in declining pulmonary function or unexpected fatal outcome has caused widespread concern. Direct person-to-person transmission has been documented and a segregation policy of CF patients colonized withB.cepaciafrom non-colonized CF patients is widely adopted. Since this policy has a dramatic impact on social behaviour of CF patients it is imperative that clinical laboratories accurately isolate and identifyB.cepaciain the respiratory secretions.In order to comprehend the epidemiology ofB.cepaciain the Belgian CF population a multicentre study was conducted during a period of 1 year (March’93-February’94).B.cepaciawas isolated in only 12 of 465 CF patients (2.6%). Roudne biochemical tests identified these strains as authenticB.cepacia.However, the combined data from protein and DNA-DNA hybridization analyses revealed that the Belgian CF“B.cepacia”isolates showed patterns different from referenceB.cepaciaisolates and belong to 3 different, newly identifiedBurkholderiagenomovars, but not toB.cepacia.

ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718514

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryDiabetic nephropathy is the most important cause of increased morbidity and premature mortality in patients with insulin dependent diabetes mcllitus. Several longitudinal studies done in different countries have shown that microalbuminuria strongly predicts the development of diabetic nephropathy in insulin dependent diabetes mellitus.Very few data arc available about the situation in Belgium. In a retrospective study we analysed the data of 271 insulin dependent diabetic patients attending the University Hospital of Antwerp during the year 1994. Normoaibuminuria was defined as a urinary albumin excretion rate of200 ng/min.In our population we find an overall prevalence of microalbuminuria of 14%. Patients with microalbuminuria are characterised by an earlier onset and i longer duration of diabetes when compared with patients with normoaibuminuria. Further we find that they have a worse glycemic control, a higher frequency of raised arterial blood pressure and a higher percentage of proliferative retinopathy. These data are comparable with those from other studies done in different countries. They show that patients with microalbuminuria should be regarded as a high risk group and therefore urinary albumin excretion rate should be monitored routinely. Also they stress the importance to strive to a good metabolic control and to an aggressive treatment of arterial hypertension.

ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718515

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryOne hundred eighty consecutive, unduplicate isolates ofHaemophilus influenzaefrom clinical specimens collected from November 1994 through February 1995 in nine general hospitals throughout Belgium were examined for p-lactamase production using a nitrocefin-based test, and for theirin vitrosusceptibilities to ampicillin, amoxycillin/clavulanate, cefaclor, cefuroxime, cefotaxime, clarithromycin and azithromycin by means of the NCCLS agar dilution test. The isolates were all from respiratory tract specimens. The prevalence of capsular type b was 1.1 %, and the overall rate of p-lactamase production 16.7%. Rates of P-lactamase production were higher in isolates from children (22.0%) than in those from adults (15.3%), and in isolates from upper respiratory tract specimens (22.0%) than in those from the lower resj Piratory tract (15.1%). Beta-lactamase-negative ampicillin resistance amounted to 1.1%. Cefotaxime had the highest activity on a weight basis [MIC (minimal

ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718516

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryVarious treatments for essential hypertrichosis are available. The aim of this study is to present our experience with a simplified thoracoscope sympathicolysis technique in this disorder, and to confront our results with data in the literature. 35 consecutive patients (11 male, 24 female, age 12–44 years) with essential hyperhidrosis, refractory to“conventional”medical treatment presenting between August 1993 and May 1994 were studied. Bilateral D2-D3 sympathicolysis was performed using a simplified one-time bilateral thoracoscope procedure under general anaesthesia. Clinical scores, complications and side effects were recorded one week, one month and one year after the intervention. Severe hyperhidrosis was present in the hands in 100%, axillae in 66% and soles of the feet in 86% of patients. In one patient, only a unilateral intervention was possible due to pleural adhesions. In the other 34 patients, palmar hyperhidrosis was completely and permanently relieved in 100% of cases. Axillar hyperhidrosis was significantly improved after one year in 91 % of patients, 52% of which showed a complete disappearance of hyperhidrosis. Side effects and complications were minimal. There were no permanent pleural, neurological (Horner) or other sequellae. Patient satisfaction was invariably very high. These findings compare favourably with historical data in the literature.Acta Clin Belg. 1996; 51–4: 244–53

ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718517

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryIn this review, after a short discussion of our knowledge about cytochrome P450 isoenzymes, two important sources of variability in the metabolism of drugs by cytochrome P450 are described, i.e. genetic factors and drug-drug interactions. Many hepatic cytochrome P450 enzymes play an important role in the oxidative biotransformation of numerous drugs and other foreign compounds, and of many endogenous substrates. In humans more than 20 different isoenzymes of cytochrome P450 responsible for the hepatic metabolism of drugs, have been identified. They are classified into families and subfamilies on the basis of the degree of amino acid similarity. Cytochrome P450 isoenzymes are regulated by both genetic and environmental factors. Of particular interest is genetic polymorphism in drug oxidation. Two genetic polymorphisms in drug oxidation are well known, the sparteine/debrisoquine (CYP2D6) polymorphism and the mephenytoin oxidation (CYP2C19) polymorphism. As a result of these polymorphisms, two phenotypes exist in the population, poor and extensive metabolizers. Poor metabolizers may be prone to adverse reactions towards drugs with a narrow therapeutic range. In extensive metabolizers clinically significant drug interactions between drugs metabolized by the same isoenzyme can occur.

ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718518

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryWe report the case of a patient with B-cell chronic lymphocytic leukemia, presenting with cough and pain in the right hemithorax. The diagnosis of an inflammatory pseudotumour in the right lower lobe bronchus was made. Clinical presentation, pathology and treatment of this uncommon tumour-like lesion are briefly discussed.

ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718519

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryWe report here on a new case ofL buccalisbacteremia. To our knowledge 16 other cases ofL buccalisbacteraemia have been reported in the literature, most of them in neutropenic patients. HoweverL buccalisendocarditis does occasionally occur in non-neutropenic patients. The identification ofL buccalisis based on well known phenotypic features and confirmed by the detection of a large peak of lactic acid by gas chromatography for non volatile organic acids.L buccalisis sensitive to a wide range of antibiotics including P-lactam antibiotics, but it is resistant to aminoglycosides and macrolides.

ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718520

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryThe authors report a case of dermatomyositis (D.M) in a 57-year-old man, associated with a squamous cell bronchial carcinoma. The complete resolution of the dermatomyositis after radical resection of the bronchial tumor strongly suggested a paraneoplastic phenomenon.

ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718521

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryComplete and permanent absence of peripheral eosinophilic granulocytes was observed in a patient also presenting with total myeloperoxidase deficiency. The anomaly was suspected because of complete absence of the eosinophilic cluster in the display of a H*3 Technicon hematological automate and was confirmed by traditional staining of more than 100.000 leukocytes. A severe infectious problem during adolescence could be related to MPO deficiencyn this patient. No specific disorder attributable to aneosinophilia was however observed subsequently.

ISSN:1784-3286    

DOI:10.1080/22953337.1996.11718522

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor