ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718366

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

SummaryPatients with non-insulin-dependent diabetes mellilus (NIDDM) are at high risk of cardiovascular disease for many reasons and especially due to the fact that dyslipidemias are more frequent in this group of patients. Fibrale derivatives are the drugs of choice when hypertriglyceridemia is the main lipid anomaly. When hypercholesterolemia is predominant, the use of resins and nicotinic acid has been advocated but these drugs arc poorly tolerated on a long-term basis.We assessed the effect of simvastatin, a recent HMG-CoA reductase inhibitor in 12 NIDDM patients with hypercholesterolemia. After 4 weeks of placebo, which did not significantly modify the lipid values, patients were given simvastatin at increasing dosages (from 10 to a maximum of 40 mg daily) during 24 weeks. Compliance and clinical tolerance were excellent. There was no major biological side effect, but a significant deterioration of glucose control was noted at the end of the study.Simvastatin reduced total cholesterol by 28%, LDL-choIesterol by 36% and apo B by 31%. Concomitantly, there was an increase of IIDL-cholesterol by 15%. This improvement of lipid profile persisted during the 24 weeks of treatment.Comparing the patients with pure hypercholesterolemia to those presenting combined hyperlipidemia, it was evident that the hypolipidemic effect was more marked in the diabetic subjects with combined hypcrlipidcmia.

ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718367

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

SummaryAlthough pathogenicYersiniahave been described several decades ago, humanYersiniainfections remain enigmatic. The high prevalence in Europe and the variety of manifestations should be known to most clinicians. BothYersinia enterocoliticaandY. pseudotuberculosismay cause similar clinical pictures. The clinical spectrum encompasses both intestinal and extraintestinal infectious syndromes and reactive or postinfectious immunological manifestations. The limited value of the currently available serodiagnostic techniques and the broad clinical spectrum make reactive yersiniosis a difficult diagnosis. Yersiniosis must be considered in the differential diagnosis of rheumatic and collagen vascular diseases. In selected indications the use of newer diagnostic tools such as immunoblotting and indirect immunofluorescence may increase the diagnostic yield in idiopathic reactive manifestations or recurrent or persisting infections of unknown origin. Recently, fluoroquinolones have emerged as promising drug when therapy is indicated.

ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718368

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

SummaryCerebrovascular disease constitutes one of the major causes of death. Patients with atrial fibrillation are known to be at high risk for stroke. The efficacy of oral anticoagulant therapy in the primary prevention of stroke in individuals with nonvalvular atrial fibrillation has been demonstrated in several large randomized trials. However, many geriatricians remain reluctant to prescribe anticoagulants. This article focuses on the risks and benefits of stroke prophylaxis with anticoagulant therapy in elderly patients with nonvalvular atrial fibrillation.

ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718369

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

SummaryPopliteal vein aneurysm is a rare cause of pulmonary embolism. We present the case of a 39-year-old man with multiple pulmonary emboli. Subsequent investigation revealed a saccular aneurysm of the right popliteal vein containing large clots. The presence of fresh thrombus was confirmed at surgery which consisted in excision of the saccular aneurysm with vein patch closure. Primary popliteal venous aneurysms are probably congenital in origin. Phlebography is diagnostic. Surgery is recommended.

ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718370

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

SummaryWe report the ease of a 71-year-old man with a prosthetic aortic valve endocarditis caused byListeria monocytogenes.He was successfully treated with a combination of ampicillin and amikacin, and valve replacement surgery.This case and previously reported cases are discussed.

ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718371

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

SummaryHistiocytosis X of the lung is associated with hone lesions in 4 to 20%. We report a ease in which the diagnosis was missed in spite of repeated bronchoscopies with transbronchial lavage. The diagnosis was finally established by isotope bone scan, subsequent skeletal CT-scan and bone biopsy.

ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718372

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

SummaryFour patients with HIV infection and severe immunodeficiency are described who developed a typical varicella zoster lesions. Three of the patients presented with chronic varicella zoster lesions. In two of them such lesions were hypcrkeratotic. All three patients had been treated initially with subtherapeutic doses of acyclovir. In one of the patients the lesions were clinically resistant to high dose acyclovir treatment and disappeared only when renal insufficiency developed during foscarnet-famcyclovir treatment. One patient developed a disseminated varicella zoster infection.

ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718373

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718374

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1994.11718375

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor