ISSN:1784-3286    

DOI:10.1080/17843286.1966.11716617

出版商:Taylor&Francis    

年代:1966

数据来源: Taylor

摘要:

SummaryPlasma renin activity has been measured with Boucher’s technique. In normal adults, the mean value of renin activity is 29,2 nanogrammes of angiotensin liberated/10 ml of plasma (S.D.±6,5). In 81 cases of essential hypertension, renin activity averaged 17,4 ng/10 ml (S.D.±4,5). In 16 cases of renal artery stenosis, renin activity averaged 80,2 ng/10 ml (S.D. + 44).However, in 5 of these cases, renin activity was only at the upper limit of the normal ranges. Normal renin plasma activity in causative renal artery stenosis can be explained in three ways :1) Systemic plasma renin activity does not reflect renal secretion in tight stenosis with low renal plasma flow; in 4 cases of renal artery stenosis with paranormal renin activity in systemic blood, renin activity in venous blood was high (304 ng/10 ml); stenotic renal artery blood flow averaged in these cases 45 ml/ minute.2) Renal blood flow and renin plasma activity may be normal in the reclining subjects and abnormally increased in erect position.3) Renin activity decreases in renal artery stenosis of long duration. None of our 5 cases of renal artery hyperplasy showed plasma renin increases neither in systemic nor in renal venous blood or in erect position. In cases of causative) renal stenosis with normal plasma renin activity in the above conditions, surgical treatment fails.

ISSN:1784-3286    

DOI:10.1080/17843286.1966.11716618

出版商:Taylor&Francis    

年代:1966

数据来源: Taylor

摘要:

SummaryRadiotherapy seems to have arrived at the limit of its therapeutic possibilities in the treatment of solid malignant tumors.At present, the association of radiotherapy and cytotoxics has not given the results which might have been hoped for, from experimental work. We believe that it is due to the fact that the modalities of administration of cytotoxics in conjunction with radiotherapy not have been determined.We have followed the action of alkylating agents, antimetabolites, plant alkaloids and antibiotics combined with X-rays on the variation of the number of nucleated cells of the bone marrow.We were not able to show a potentialization effect but just to show an additive effect of varying degrees.However, we have been able to classify this cytotoxics into drugs with a weak and short-termed action, and those with a more intense and long-termed action.In general, the alkylating agents belong to the first group, except for myleran; the others belong to the second.We were able to conclude that in the case of association with X-rays, the drugs of the first group must be repeated daily, and those of the second group only every three days.One is able to give an important local dose of radiation to a tumor and increase the action of this dose by a cytotoxic administered at a minimal dose.A radioresistant tumor can be cured by this association therapy.We were also able to show that the association of a cytotoxic of the first group with one of the second group has the same effect as an association of X-rays and a cytotoxic of the second group.The association of cytotoxics alone can only be preferred in exceptional cases, for its effect on the economy and immunity is more harmful.In cases of the most radioresistant tumors, association of two cytotoxics with different actions and X-rays can be very useful.

ISSN:1784-3286    

DOI:10.1080/17843286.1966.11716619

出版商:Taylor&Francis    

年代:1966

数据来源: Taylor

摘要:

SummaryA renal carcinoma occurring thirty years after a retrograde pyelography with Thorotrast is described. The case is illustrated by X-rays, histologic and autoradiographic findings. The mechanism, the diagnostic difficulties and the treatment of the Thorotrast kidney are discussed.

ISSN:1784-3286    

DOI:10.1080/17843286.1966.11716620

出版商:Taylor&Francis    

年代:1966

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1966.11716622

出版商:Taylor&Francis    

年代:1966

数据来源: Taylor