ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717084

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryWe have analyzed the initial clinical aspect and the clinical, electroencephalographic and biological evolution of six successive patients who developed fulminating hepatitis with coma. Three of them were able to overcome the acute period of severe hepatic failure and were completely cured after a few weeks whereas the other three progressively developed signs of irreversible brain damage and died.Once or twice a day, each of the patients was submitted to plasmapheresis. This treatment was usually associated with corticosteroids, L-Dopa, neomycin and lactulose, without any apparent influence of these drugs on the evolution of the disease. The two groups of patients were similar with respect to their initial neurological aspect but, using the possible evolution towards recovery or death as the discriminant, some biological differences seemed to be present between the two groups. We noticed that the patients with an unfavourable evolution usually had a metabolic acidosis with respiratory alkalosis ; the levels of cytolytic enzymes and arterial ammonia were higher whereas the coagulation factors were as much disturbed in one group as in the other.The evolution of the electroencephalographic disturbances was parallel to the clinical ones; the same was often true for blood urea (4 cases out of 6).The reasons why we chose plasmapheresis as the method of temporary hepatic support rather than other methods is discussed. The precautions to be taken and the possible risks are also outlined.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717085

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryA case of thallotoxicosis during the first trimester of pregnancy is presented.Thallium intoxication during pregnancy or during embryogenesis can cause abnormalities, especially skeletal, in laboratory animals.Up to now six cases of human thallium intoxication during the first trimester of pregnancy have been reported. No congenital abnormalities were mentioned but on these data no definitive conclusion can be drawn. When intoxication occurs after the first trimester, only some of the newborns have symptoms compatible with thallo-toxicosis.Among these symptoms are mentioned alopecia, rash, low birth weight and premature birth. Serious intoxication of the mother at the end of pregnancy can cause the death of the newborn.Abortion never occurred when thallium was taken for this purpose.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717086

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryThe clinical histories of eight patients with posterior mediastinal“goître”and some brief notes on pathology, signs and therapy of this rather unfrequent localisation of intrathoracic goïtre are discussed. It is emphasized that as soon as the diagnosis is established, the sooner if it is not, excision is the only therapeutic measure worthwhile. Postlateral thoracotomy, in some instances combined with cervical incision, seems to be the best procedure in these cases.However, while establishing differential diagnosis it should be remembered that these“posterior goîtres”are almost exclusively located to the right of the mediastinum in anteroposterior chest roentgenograms.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717087

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryWe describe the incidence of 24 M-components among a population of 23,390, once or more examined blood-donors. They were followed up and controlled half-yearly. At the beginning of 1974 a medical check-up was performed with bone marrow smears, Rontgen examination, etc. We were able to distinguish 5 classes:1)myeloma or macroglobulinaemia2)probable myeloma or macroglobulinaemia3)essential monoclonal gammopathy (m.g.)4)transient m.g.5)dubious m.g.Our data are very similar to those of other population studies. The appearance of essential and transient m.g. is discussed.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717088

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryIn this paper, several aspects of the radioimmunoassay (RIA) method for digitalis glycosides are discussed. Although this method is used routinely, the results are not always accurate. Kits for RIA of digitalis glycosides are commercially available, but antibodies, e.g. against digoxin, can easily be obtained in rabbits : high titers are reached within a few months.The general procedure is described ; results can be calculated from a calibration line. The coefficient of variation«within run»and«between run»for the assay of digoxin in patient serum is approximately 10%.The RIA method has a limited specificity, and cross-reaction between different glycosides is present; this makes it possible to measure several glycosides, including digitoxin, using the antibodies against digoxin. Metabolites of digoxin and digitoxin interfere with the determination of the parent molecules.Important discrepancies exist between the results obtained with the different commercial kits : literature data and personal experience are cited.In a final paragraph, known sources of error are discussed. When performing RIA of digitalis glycosides, one should never forget the possibility that smaller or larger errors of measurement are possible.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717089

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryAssay of digitalis glycosides in man can now be done easily. In what circumstances is such a measurement meaningful?First of all, assay methods have allowed studies that have furthered our knowledge about digitalis and its use. These methods have drawn attention to the problem of bioavailability of digoxin : differences between different oral preparations, but also between different tablet brands are certainly important for the practical use of the drug. We know also more about the use of digitalis glycosides, mainly digoxin, in renal failure and the data derived from studies of plasma levels have allowed us to set up equations for calculating the daily digoxin requirement as a function of the degree of renal failure.Another aspect is whether it makes sence to measure the plasma levels of a glycoside to improve therapy in the individual patient. If the patient is doing well, measuring a plasma level does not learn much, except if the patient is in renal faillure. A plasma level can be helpful if a patient does not respond to therapy, or if toxicity suspected.Plasma levels of digitalis glycosides can be helpful, but only in some circumstances.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717090

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717091

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717092

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717093

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor