ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717915

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

SummaryFifty three children aged between 10 weeks and 12 8/12 years were treated for a haemolytic uraemic syndrome. A prodromal phase was present in 49 patients (gastroenteritis: 46, respiratory tract infection: 3) and a possible aetiological factor was discovered in 36 patients. Coxsackie Was the most frequently encountered pathogen. Treatment consisted of fresh frozen plasma infusion and antiplatelet drugs. Two patients also underwent plasmapheresis. One patient received imunosuppressive drugs. Twenty five patients underwent peritoneal dialysis. The outcome was good in all cases. One child still presents a mild Proteinuria 7 1/2 years after diagnosis while all the other patients had a complete normalisation of the parameters.

ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717916

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

The susceptibility of 841 unselectcd, gramnegative bacterial isolates to augmentin, an amoxycillin/clavulanic acid formulation, was examined and compared with their sensitivity to other antibiotics. Susceptibility was measured using a disk diffusion procedure. Augmentin showed a high degree of activity against the folates tested. Overall rates of sensitivity, intermediate sensitivity, and resistance to augmentin among theEnlerobacleriaceaewere 81.6%, 7.6%, and 10.8%, respectively. As expected, a considerably higher degree of resistance occured to ampicillin (58.4 %). The antibacterial pattern augmentin compared favourably with that of the second-generation cephalosporin, cefuroxime. These results indicate that augmentin is likely to be clinically active against a conquerable number of community and hospital-acquired gram-negative strains.

ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717917

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

SummaryShoshin beriberi is the fulminant form of beriberi heart disease, due to acute thiamine deficiency.In this report, we describe the case of a 34-ycar-old malnourished alcoholic man, who was studied in the acute phase of shoshin beriberi, with high-output cardiac failure, loss of Peripheral vascular resistance and severe Metabolic acidosis.Pathogenesis and possible mechanisms of this very rare complication of chronicalcoholism are reviewed.

ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717918

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

SummaryNcopterin, a precursor of biopterin, is released by macrophages during allogeneic response and in vitro data suggest that the release ofγ-interferon by the T-cell triggers neopterin excretion. In order to determine the clinical relevance of serum neopterin levels, serial serum samples of seven allogeneic bone marrow recipients were measured by a radioimmunoassay and evaluated retrospectively. As reported by others, very high levels of neopterin:±100 nMol/L (n:<10) are observed in patients with graft-versus host-disease (GVHD) or when severe viral infection occured and in all cases, the rise of neopterin level preceeded and/or correlated with the clinical manifestations. The reappearance of leukemic blasts was also associated with rising neopterin level, but the value never reached 50 nMol/L. Although neopterin as a marker is not specific for any of these complications, its daily evaluation allows to identify patients at risk for major clinical complications. Moreover, the striking increase of neopterin level during GVHD suggests thatγ-interferon plays a role in the pathogenesis of this reaction. Further investigations are needed to better document this hypothesis.

ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717919

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

SummaryOur work, centered on hormone dependency hreast cancer, has therapeutic and fundament al implications in two main domains:1. Characterization of hormonal responsiveness by receptor assays:Among clinical, biochemical and pathological data, estrogen receptors (ER) are the best barkers of responsiveness to hormonal treatments. The quantitative assay is particularly informative, and a model linking ER concentration to the probability of response has been created, nich guides the clinician for the treatment of indual patients. It is also helpful for the Prospective study of new treatments on groups of Patients.2. Use of interactions between hormones and Wotoxic drugsOn a murine model, it was shown that one single pulse of estradiol exerts a transientvmitogenic effect. This manipulation allows, under very stringent conditions, to amplify the an titumioral action of a cycle-active cytotoxic drug.The concept is now under study in a randomized clinical trial in which patients receive chmotherapy preceeded either by estrogenic receruitment or by placebo.

ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717920

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

SummaryA 66 year-old woman presented (1 year after a Myocardial infarction) with a large embolic Stroke which resolved completely under heparin tretment. As in most published cases, the cmbolization cannot be absolutely demonstrated. Alrge cardiacthrombus, partially mobile in a left venricular aneurysm was discovered by 2-dimensional echocardiography. The size and mobility of thrombus prompted us to perform aneurysmectomy with thrombectomy, to prevent repeated embolization. Early evolution was uneventful but the patient died suddenly 6 months The role of the left ventricular aneurysm as an embolic source, and its treatment arc disused.

ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717921

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

SummaryThe authors describe a case of symptomatic hyponatremia developing within a few days after the initiation of an antiarrhythmic treatment with Propafenone.Clinical and biological data suggest a syndrome inappropriate ADH induced by propafenone.

ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717922

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

SummaryWc report a case of severe isolated leukopenia in a patient with advanced breast cancer treated with aminoglutcthimide. Our patient had received no radiation therapy or cytotoxic chemotherapy during the six months prior to admission. Examination of the bone marrow revealed no abnormal cell infiltration. The patient recovered spontaneously. Wc believe that the leukopenia of this patient was due to aminoglutcthimide.

ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717923

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1988.11717924

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor