ISSN:1784-3286    

DOI:10.1080/22953337.1979.11718668

出版商:Taylor&Francis    

年代:1979

数据来源: Taylor

摘要:

SummaryExploration of uremic acidosis in patients with severe CRF (creatinine clearance<20 ml/min) by means oi an crat NH CI loading test in combination with an IV HCO-3loading test, reveals the existence of three subtypes of acidosis.One particular type, characterized by tubular acidification disturbances and persistent bicarbonaturia in severe metabolic acidosis, is frequently seen in chronic interstitial nephritis. The acidification disturbance is probably related to the frequently associated salt wasting state of these patients. Since salt wasting in interstitial renal diseases can be prevented by gradual adaptation of the dietary salt intake, this therapy could also be useful to treat the associated, sometimes severe, acidosis.

ISSN:1784-3286    

DOI:10.1080/22953337.1979.11718669

出版商:Taylor&Francis    

年代:1979

数据来源: Taylor

摘要:

SummaryA case of angio-immunoblastic lymphadeno pathy is reported. The patient is a 56-year old female. Shexhibited a generalized lymphadenopathy of acute onset, hepatosplenomegaly, edema, rash and general symptoms. Polyclonal IgVI dysproteinaemia was present. Deterioration of the patient’s condition was accompanied by a rarely described aregenerative anaemia. Pathological findings before and during steroid treatment are described in detail. Treatment seems to have caused hyalinisation of the vessels and differentiation of the cell population to small lymphocytes with disappearance of younger immunoblasts and plasmocytes.

ISSN:1784-3286    

DOI:10.1080/22953337.1979.11718670

出版商:Taylor&Francis    

年代:1979

数据来源: Taylor

摘要:

SummaryTwenty-two patients with mild to moderate hypertension participated in a double-blind trial during 7 weeks in order to compare the antihypertensive effect and biochemical properties of tienilic acid 250 nig u.i.d. and hydrochlorothiazide 50 mg u.i.d. Reduction of systolic and diastolic blood pressure was similar with both drugs. At therapeutic doses, a slight decrease in scrum potassium was observed in both groups. Tienilic acid significantly decreased whereas hydrochlorothiazide significantly increased serum urate levels. Both diuretics were well tolerated. This study confirms that, in contrast to other thiazide diuretics, tienilic acid produces an important hypo-uricaemic effect.

ISSN:1784-3286    

DOI:10.1080/22953337.1979.11718671

出版商:Taylor&Francis    

年代:1979

数据来源: Taylor

摘要:

SummaryThe authors review the effect produced by paired action of gaseous pollutants and microorganisms on alveolar macrophages. When tobacco smoke acts in vivo, the number of alveolar macrophages harvested from lung washings, in man or animals, is most often increased. The treated phagocytes show the characteristics of«activated»macrophages: marked glass-adherence and cytoplasm filled with various organites (lysosomes, Golgi vesicles, mitochondriae and residual bodies). Although the phagocytic properties of the cells are preserved, a reduction of their germicidal activity towardsEscherichia coliandStaphylococcus aureus,is observed in the guinea-pig. When the macrophages cultivated in vitro, are exposed to tobacco smoke the pollutant depresses their physiologic activity: decreased glass-adherence, pycnotic aspect of the nucleus, vacuolisation of the cytoplasm, reduction of the phagocytic and germicidal activities towardsStaphylococcus albusandepidermidis.Enhancement of infectious processes by nitrogen dioxide has been demonstrated in monkeys, hamsters and mice, when the animals were first exposed to the gas and then infected with an aerosol prepared withKlebsiella pneumoniaeor withStaphylococcus aureus: a reduction of the pulmonary clearance of the germs was observed. Experiments carried out on guineapig alveolar macrophages cultures exposed to nitrogen dioxide, reveal a reduction of the phagocytic activity of these cells towardsStaphylococcus aureus.Sulfur dioxide exerts a cytotoxic effect on rat alveolar macrophage? cultivated in vitro in contact with the gas, as well as a decrease of cellular viability. The latter observation contrasts with a stimulatory effect on carbohydrate metabolism and an increase of several enzymatic activities. Ozone exerts a cytotoxic action, as demonstrated in vivo on rabbit alveolar macrophages, as well as in vitro on rat alveolar macrophages. Moreover, an inhibition of microbial phagocytosis in the alveolar macrophages was observed in rabbits infected withStreptococcusgroup C Lancefield by tracheal route. On the whole, the gaseous polluants studied here exerted an inhibitory action on the anti-infectious function of the alveolar macrophage, which is more pronounced in vitro than in vivo; the inhibitory action affects the germicidal rather than the phagocytic function of these cells.

ISSN:1784-3286    

DOI:10.1080/22953337.1979.11718672

出版商:Taylor&Francis    

年代:1979

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/22953337.1979.11718673

出版商:Taylor&Francis    

年代:1979

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/22953337.1979.11718674

出版商:Taylor&Francis    

年代:1979

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/22953337.1979.11718675

出版商:Taylor&Francis    

年代:1979

数据来源: Taylor