摘要:

SummaryThe reasons why the attainable serum concentration is the principal criterium for standardising Neo-Sensitabs are given, and at the same time details are shown of the interpretation of inhibition-zone readings. The elaborate co-operation between production department and control laboratory in the manufacturing process is described, and subsequently results from stability checks, performed by a microbiological method and by a chemical extraction method, are presented.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716866

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryThis report discusses an important source of discrepancy between results obtained with different systems of antibiotic sensitivity testing with the disc method : the lack of normalization of the number of sensitivity-categories and of the critical M.I.C. values which delimit these categories. The advantages and inconvenients of the three-and the four-category systems are briefly commented. The definition of uniformly adopted critical concentrations should be confided to a National Working Group, so that different testing systems can be adjusted accordingly.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716867

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryThe clinical and anatomical study of a case of alveolar proteinosis complicated of infestation by nocardia asteroides is reported.Several pathogenic hypotheses are discussed. The authors advise the systematic use of“transparietal”pulmonary biopsy in order to obtain a histological diagnosis.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716868

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryLong-term treatment with the combination trimethoprim-sulphamethoxazole nearly always causes hematologic disturbance. The most frequent changes in sixteen patients, treated for 6 weeks or more, were : hypersegmentation of the granulocytes, decrease of the reticulocytes, elevation of indirect bilirubine and a shift to the left in the myeloid series of the bone marrow. Three patients had a moderate and reversible granulopenia. These side effects illustrate the necessity of hematological controls in prolonged therapy by this antibiotics. This control is indicated even for short-term treatment in patients with possible disturbance of folic acid metabolism : in two cases, an alcoholic with malnutrition and an epileptic patient treated by barbiturates, the authors observed a granulocytopenia already after twelve days.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716869

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryThe author describes a model to calculate the slope of the regression line of any antibiotic agent from its molecular weight.It deserves again notice that considerable variations exist among authors on the subject of critical concentrations, thus accounting for diverging results in sensitivity testing by different methods.The author is of the opinion that the clinician should have a better knowledge about the pharmacokinetics of the different antimicrobials, and he shows by means of a table the tissue concentrations of the most common antibiotic agents.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716870

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryIn a series of 60 patients with myelomatosis, 10(17 %) had a hypocholesterolaemia of less than 150 mg/100 ml at the time of diagnosis, always combined with a very high concentration of the M component. 6 of these cases had an IgA and 4 an IgG myeloma.In 5 subjects a pronounced decrease of myeloma immunoglobulin was obtained on melphalan treatment, accompanied in all of them by a normalisation of the cholesterol level ; of the 5 patients without any objective response, 4 conserved the low serum cholesterol.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716871

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716872

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor