ISSN:1784-3286    

DOI:10.1080/17843286.1974.11716939

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor

摘要:

SummaryAn attempt was made to replace the more conventional approach to antihypertensive therapy ("cuff" approach) by antihypertensive therapy based on physiopathological findings (physiopathological approach). The use of beta adrenergic blocking agents in hypertensive patients with high cardiac output and of peripheral vasodilating antihypertensive agents in patients with increased total peripheral resistance was discussed. Sodium depletion by diuretics and low sodium diet was advised in high plasma volume types of hypertension, but also in other hypertensive patients. The possibilities of a more specific antihypertensive therapy in patients with low and high plasma renin levels was assessed. The importance of a prognostic approach in the treatment of hypertensive patients was stressed.

ISSN:1784-3286    

DOI:10.1080/17843286.1974.11716940

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor

摘要:

SummaryA blood pressure survey was made of a cross-section of tie Belgian population, consisting of about 2.000 people (71% of whom were women) their ages ranging from 20 to 60 years. After ten minutes recumbent rest, four consecutive measurements of blood pressure were made. An interview with each person permitted the existence of Previously known hypertension and possible antihyperensive treatment to be taken into account.The distribution of systolic and diastolic pressures was studied and revealed curves comparable to those in the existing literature. Between the ages of 20 and 40 years, women nave, on the average, lower pressure than men.When the blood pressure (average of 4 measurements) exceeded 140/90 mmHg, another examination was made to three weeks later. On the basis of these two determinations, the individuals were classified as normal (66%)hypertensive (on both determinations more than 160/95 mmHg : 11%) and borderline hypertensive (23%).Among the hypertensives, more than a third were not aware of their condition, a quarter were not treated, and 15 % were hypertensive in spite of treatment.This enquiry, even in its preliminary stage, is very revealing about the frequency of high blood pressure in our country and points out the lack of information of the public as well as of the doctors concerning the pathogenic role of hypertension.

ISSN:1784-3286    

DOI:10.1080/17843286.1974.11735726

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor

摘要:

SummaryAn epidemiological survey amongst 3,001 subjects between the ages of 45 and 64 in the Burgh of Renfrew, Scotland, revealed that 468 (15.6 %) subjects had a diastolic blood pressure of 100 mmHg or more. Examination of the General Practitioner's medical records of those subjects whose diastolic blood pressure was less than 100 mmHg revealed 55 subjects who were receiving antihypertensive treatment and a further 113 subjects who were receiving no antihypertensive therapy, but who had previously been recorded as having a blood pressure above this level (Total 636 ; 21.2 % of survey).Investigation of the severest cases of hypertension has demonstrated no cases of primary hyperaldosteronism and a frequency distribution curve for plasma angiotensin II concentration among this group shows no evidence of a subpopulation of subjects with low levels.

ISSN:1784-3286    

DOI:10.1080/17843286.1974.11716942

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1974.11716943

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor

摘要:

SummaryThe greatest concentration of radioactive microspheres, injected into the vertebral artery, was found in pons, medulla and cerebellum. Under barbiturate anaesthesia. local administration of angiotensin, 10 ng/kg, or noradre-naline, 100 ng/kg, increased the amount of microspheres arriving in the intracranial structures and decreased the amount arriving in the neck muscles. Under chloralose anaesthesia, angiotensin 10 ng/kg, decreased the amount of microspheres in intracranial and extracranial tissues. This angiotensin-dose did not provoke hypertension.

ISSN:1784-3286    

DOI:10.1080/17843286.1974.11716944

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor

摘要:

SummaryEectric stimulation of the hypothalamus elicits an immediate systemic pressor reaction and a tenfold increase of adrenalme- and noradrenaline-concentration in venous blood of anaesthetized dogs. During the hypothalamic simulatlon, a slight increase of catecholamines occurs in the femoral venous blood returning from the pump-perfused hind leg. The induced hypertension is accompanied by a slight femoral vasoconstriction or even by a femoral vasodilatation in some cases. The haemo dynamic and biochemical findings clearly indicate that the femoral circulation has only a minor participation in the general orthosympathetic cardiovascular effect of hypothalamic stimulation.

ISSN:1784-3286    

DOI:10.1080/17843286.1974.11716945

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor

摘要:

SummaryModuretic®has been used for long-term treatment in 47 hypertensive patients, at the daily dose of 1 tablet (50 mg hydrochlorothiazide and 5 mg amiloride) for at least 3 months in all cases, and for more than 1 year in 30 cases. Blood pressure was recorded at monthly or bimonthly intervals following an open trial schedule. After 1, 3, 6 and 12 months of treatment, serum electrolytes, urea, creatinine and uric acid were determinated. The hypotensive effect of Moduretic®was comparable to that obtained with other diuretics, like chlorthalidone 50 or 100 mg per day. No significant variations were observed concerning natraemia and calcaemia. The mean value of kalaemia remained normal in the course of 12 months. As compared with the low values observed in the patients previously treated with chlorthalidone there was a significant and sustained increase of kalaemia. Moderate increases of blood urea, creatinine and uric acid were observed but were of the same magnitude as those noted in the patients previously treated with clorthalidone or other diuretics.

ISSN:1784-3286    

DOI:10.1080/17843286.1974.11716946

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor

摘要:

SummaryHaemodynamic parameters and vascular reactivity to norepinephrine were determined in 24 borderline hypertensive patients in comparaison with 12 normal subjects. Borderline hypertensives had high values of blood pressure (P<0.001), cardiac index (P<0.01) and heart rate (P<0.05) and normal values of total peripheral resistance. The pressor dose of norepinephrine was significantly increased (P<0.001) and was directly correlated with the cardiac output (P<0.001). This result was not observed with the angiotensin and isoproterenol and could suggest the role of the adrenergic system in borderline hypertension.

ISSN:1784-3286    

DOI:10.1080/17843286.1974.11716947

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor

摘要:

SummaryWhen angiotensin II was infused into fifty-one unselected subjects a linear relationship was found between the increment of diastolic blood pressure and the logarithm of the rate of infusion of angiotensin II. The slope of this line was found to be very reproducible on repeated determinations in the same subject.When the correlations between pre-infusion plasma renin activity and various functions derived from dose-response curve were determined, it was observed that :1) the significance of the correlation became progressively stronger when increasing thresholds of the pressor response to angiotensin II were considered ;2) the best correlation was achieved when the slopes of the individual dose-response curves were plotted against the logarithm of corresponding plasma renin activities.These results suggest that the slope of the pressor dose-response curve is the most reliable index of responsiveness to intravenously infused angiotensin II ; and that it may provide a satisfactory guide to the basal plasma renin activity.

ISSN:1784-3286    

DOI:10.1080/17843286.1974.11716948

出版商:Taylor&Francis    

年代:1974

数据来源: Taylor