摘要:

SummaryKnowledge of the serum protein binding of drugs can be of clinical importance. After discussing the different methodological aspects of measuring protein binding, the effects of binding on different pharmacokinetic parameters are reviewed. Drug protein binding in serum can change: interaction between drugs and the influence of renal failure, liver disease and age upon the binding are surveyed. Finally the problem of monitoring plasma levels of drugs in the presence of changed protein binding is mentioned.

ISSN:1784-3286    

DOI:10.1080/22953337.1978.11718629

出版商:Taylor&Francis    

年代:1978

数据来源: Taylor

摘要:

SummaryAfter a short description of the Hepatitis B virus (HBV>, its newly associated antigen-antibody systems are briefly introduced. The natural course of hepatitis is then presented with regard to the evolution of these serological markers, whose clinical significance is discussed. An’mmunercsponse responsible for the destruction°f the HBV infected hepatocytes is proposed and related to the various clinical pictures commonly encountered Virus transmission, epidemiology and prognose of hepatitis B are reviewed and also the Possibilities of prevention, i.e. passive (specific and non-specific gamma globulins) and active immunization.

ISSN:1784-3286    

DOI:10.1080/22953337.1978.11735734

出版商:Taylor&Francis    

年代:1978

数据来源: Taylor

摘要:

SummaryThe male partner is the cause of childlessness in about one out of two barren couples. He may be completely infertile; however in most eases subfertility is found.Subfertility is the result of either intrinsic testicular deficiency in spermatogenesis, or general (endocrine) disease. Frequently it is due to disturbance in scrotal venous circulation or to“Section of the accessory sex glands.Chronic aspecific epididymitis is often difficult to detect on clinical or biochemical grounds and diagnostic (surgical) scrotal exploration may be indicated. The diagnosis of non-specific chronic Prostato-vesiculitis may be difficult as well, therefore the author develops a set of diagnostic criteria based on:1. Data from the patients history and clinical examination;2. Cytological and bacteriological analysis of the Prostatic expression fluid or urinary sediment alter prostatic massage.3. Cytological, biochemical and bacteriological examination of the ejaculate.The treatment of infectious or inflammatory disease of the accessory sex glands makes use of n appropriate antibiotic together with an anti-inflammatory drug. The treatment should be c°ntinued for a sufficiently long period of time.Varicocele is a frequent finding in subfertilemen. In 3/4 of cases the diagnosis is made by scrotal palpation; in 1/4 of cases however spermatic venous reflux may exist without clearly palpable varicosity of the scrotal pampiniform plexus.In these cases of subclinical varicocele, the diagnosis is based on scrotal telethermography and on retrograde venography of the internal spermatic vein.Since extra testicular factors in male subfertility may be treated succesfully, it is of the utmost importance to always perform systematic diagnostic work-up in order to detect this pathology.

ISSN:1784-3286    

DOI:10.1080/22953337.1978.11718631

出版商:Taylor&Francis    

年代:1978

数据来源: Taylor

摘要:

SummaryThe authors report a case of colchicine intoxication associated with an adult respiratory distress syndrome. They implicate the role of the toxic substance in the apparition of this syndrome.

ISSN:1784-3286    

DOI:10.1080/22953337.1978.11718632

出版商:Taylor&Francis    

年代:1978

数据来源: Taylor

摘要:

SummaryThe topic of this paper concerns the clinical applications of the M mode echocardiography for the adult patients. The method offers the possibility to diagnose mitral and aortic disease with significant anatomical damage even when the auscultatory signs are lacking. In the cases of cardiomegaly it can differentiate: hypertrophy, dilatation and pericardial effusion.Suspected mitral prolapse and idiopathic hypertrophic subaortic stenosis are easilly confirmed or excluded.The qualitative or semi-quantitative analysis of the mitral echo, the ventricular dimensions, the myocardial thickness and the movements of the septal and posterior walls lead to hemodynamic interpretations. The limitations of the method in this field are briefly discussed.The conclusions outline the clinical situations in wich an echocardiogram is recommanded.

ISSN:1784-3286    

DOI:10.1080/22953337.1978.11718633

出版商:Taylor&Francis    

年代:1978

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/22953337.1978.11718634

出版商:Taylor&Francis    

年代:1978

数据来源: Taylor