ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717887

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryThe role of platelets in arterial thrombosis explains the interest of platelet kinetics.The platelet turnover is increased in evolutive arterial thrombosis, in patients with rheumatic heart disease or with substitute heart valves and in patients with active arterial disease.Correction of the increased platelet turnover is observed after treatment with platelet blocking agents.Patients with high risk of thromboembolism could possibly be recognized by means of platelet kinetics.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717888

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryThe collagen fibrils of the subendothelium, the blood How rate, the factor VIII complex and a binding site in the platelet membrane are some of the essential factors contributing to platelet adhesion to the damaged vascular wall.Adhering platelets release their content: ADP, 5HT, factor 4…as well as a factor which induces smooth muscle cell proliferation.Saturated fatty acids and cholesterol make platelets more responsive to the circulating agents (ADP, adrenaline, thrombin) and to collagen. The interest of common and new methods for the study of platelet function is briefly discussed.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717889

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryCommonly used coagulation technics are not useful for detection of hypercoagulable states. Increase of factor VIII coagulation activity and particularly of factor VHI-related antigen is evident in hypercoagulable states but not pathognomonic.Cold promoted activation of factor VII, wellknown during oestrogen therapy, is found in IS % of individuals without hormonal therapy. It is not yet known whether that activation can be related with thrombotic states.Increase of plasma antiheparin activity could be related to platelet factor 4 release. Such increase is sometimes observed in thrombotic accidents but is not found in all cases.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717890

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryThe main techniques for detection and quantitation of fibrinopeptide A and fibrin monomers, and the application of these techniques to the diagnosis of low grade or local activation of intravascular coagulation, are briefly reviewed. Radioimmunoassay of FPA provides direct, sensitive and specific quantitation of thrombin activity; elevated levels of FPA have been found in numerous clinical situations in which there is intravascular activation of the clotting system. Among the various tests for the detection and quantitation of fibrin monomers, agarose gel chromatography and affinity chromatography on insolubilized fibrinogen appear to be the most useful for the diagnosis of low grade or local intravascular coagulation in several diseases. All these tests, however, are not yet rapid or simple enough to be applicable to routine clinical testing.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717891

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryThe measurement of scrum-fibrin-degradationproducts (FDP) may be of value in diagnosing pulmonary embolism. However one has to taken into account that the increase of serum-FDP is only transient. The measurement of the serumFDP level is less useful in the detection of deep vein thrombosis. Elevated levels during the acute phase of myocardial infarction may have a prognostic value.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717892

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryIt has been found that a certain group of individuals fail to release, or release only very small amounts of plasminogen activator on exposure to a standardized stimulus (poor responders).For measuring the fibrinolytic response or capacity, venous occlusion of the limbs is a rather simple method, without potential sideeffects, which makes it suitable for routine clinical practice.The fibrinolytic activity or the blood obtained from the occluded arm proved to be 3 to 4-fold that of blood from the occluded leg, with a close correlation between both values.A strictly standardized technique must be applied to obtain reproducible results.A low response is observed with advancing pregnancy, in obesity, diabetes and in 38 % of patients with recurrent venous thrombosis. The response in Takayasu’s disease is poor or absent.Release assays with vasopressin (VP) and with a synthetic derivative (DDAVP), even moreactive than VP but devoid of side-effects, showed an impaired fibrinolytic response in patients with thrombotic disease. Further studies on the response to DDAVP in various clinical materials are desirable

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717893

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryBoth the thrombin-antithrombin III and plasmin-antiplasmin complexes contain antigenic structures which are not present in the parent molecules, to which precipitating and non-crossreacting antibodies can be prepared.Using a simple latex agglutination test, in which polystyrene particles were coated with specific immunoglobulins, these complexes were measured in purified systems and in the blood. The purified precursor molecules were at least 100 times less reactive than the complexes. Normal human plasma had agglutination titers of less than 1/8 in both tests and this value increased tot approximately 1/500 following activation of the coagulation or fibrinolytic system. In the plasma of patients during thrombolytic therapy, the plasmin-antiplasmin titer increased to values of approximately 1/250 and disappeared with a half-life of several hours.In patients with overt signs of diffuse intravascular coagulation, markedly increased titers for both complexes were consistently observed. These results indicate that activation of the coagulation or fibrinolytic system in vivo is associated with the appearance of circulating thrombin-antithrombin III or plasmin-antiplasmin complexes, which can be directly assayed in plasma on the basis of their neoantigenic expression.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717894

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryAn experimental model has been developed in the white Wistar rat lor the study of arterial thrombosis and atherogenesis. The method was standardized for thrombus registration. The ultrastructural controls 24 hours after endothelial desquamation show marked hypertrophy of both smooth muscle cells and endothelium.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717895

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryRecent physiopathological data attribute to the platelets an ever more important role in the thrombogenesis. Therefore is the oral anticoagulant use only maintained is some definite conditions which have been indicated in this review.From the first statistical significant studies published, it appears that some platelet function inhibitors useful in clinical trials, are potent in some clinical cases and ineffective in others.It is still premature at present to give definitive conclusions about the real antithrombotic value of these drugs because most of the epidemiological studies are currently underway in different countries.It appears meanwhile that the combination of these two kinds of drugs (anticoagulants and platelet inhibitors) and«a fortiori»their grouping with a third agent like fibrinolysis activators can constitute a more effective approach of the thrombosis prophylaxis.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717896

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor