摘要:

SummaryTwelve patients presenting an acromegalic syndrome (six men and six women) were studied from the point of view of thyroid, adrenal and gonadal functions. Acromegaly with global hyperfunction has not been observed. A certain degree of hypercorticism was demonstrated in several female patients. On the other hand, eleven of these patients showed signs of hypofunctioning of one or more endocrine glands. Four of them, which had not been submitted to any particular treatment, were completely pituitary-deficient (Simmonds disease, burned-out acromegaly).The results of pituitary radiotherapy must then carefully been intrepreted in the light of a possible spontaneous, regressive evolution of the intrasellar tumor by thrombosis, hemorrhage, compression and necrosis.In some cases, a thorough history taking of the patient reveals an additional point of interest : that sometimes a primary target-gland insufficiency, especially gonadal, may precede by several years the eruption of the hypertrophic phenomenon caused by acromegaly. The hypothesis of an acromegaly secondary and reactional to a peripheral endocrine deficit is evoked.One male patient presenting signs of a fullblown hypofunction of the pituitary was submitted to a metabolic observation to study the effects on electrolytes excretion during ACTH injections and the oral administration of cortisone, hydrocortisone and prednisone. Prednisone appeared to be remarkably effective as substitution therapy.

ISSN:1784-3286    

DOI:10.1080/17843286.1958.11717521

出版商:Taylor&Francis    

年代:1958

数据来源: Taylor

摘要:

Summary1. Twenty cases of Henoch-Schoenlein Purpura (HSP) are described in adult patients from 24 to 76 year old.2. The clinical characters are analyzed. The frequency distribution of the symptoms is the same as for the children : purpura (100 %), arthralgia (90 %), intestinal bleeding (57 %) and hematuria (57 %). The degree of the renal involvement determines the prognosis.3. The allergic etiology of the HSP was demonstrated with certainty in 3 of our patients. The causal antigens were respectively sulfa drugs, cow milk and extracts from B. coli.4. The recent advances made in the physiopathology of the disease are discussed.5. No particular therapy can be presently advocated with certainty.

ISSN:1784-3286    

DOI:10.1080/17843286.1958.11717522

出版商:Taylor&Francis    

年代:1958

数据来源: Taylor

摘要:

SummaryA case of renal tubular acidosis is reported.The prominent clinical feature in this case was recurrent attacks of paralysis due to hypokaliemie.Laboratory data showed hyperchloraemic acidosis and hypophosphataemie associated to hypokaliaemie. Ammonie production and acidification of urine were markedly impaired.Biological studies permitted to draw the following conclusions :a) Infusion of glucose and ingestion of NH4Cl lowered plasma potassium to paralytic level.b) Renal threshold of bicarbonate was markedly reduced.c) Excessive urinary loss of potassium was much more obvious at low plasma level of potassium than when normal plasma potassium was restored.d) Hyperphosphaturie seemed to be directly related to potassium depletion.e) KCl administration greatly increased urinary output of calcium and magnesium.

ISSN:1784-3286    

DOI:10.1080/17843286.1958.11717523

出版商:Taylor&Francis    

年代:1958

数据来源: Taylor

摘要:

SummaryThe literature dealing with the Gardner syndrome is reviewed. The author describes the case of a 29 year old male patient presenting colic polyposis, with malignant changes and multiple epidermoid cysts. This patient suffered also from mental retardation, gonadal deficit and syphilis.

ISSN:1784-3286    

DOI:10.1080/17843286.1958.11717524

出版商:Taylor&Francis    

年代:1958

数据来源: Taylor

摘要:

SummaryA case of mitral stenosis is described in a woman fifty years of age, with chronic auricular fibrillation and cardiac failure. An extensive parietal calcification of the left auricle was diagnosed in vivo seven years before death. The autopsy showed that the calcium deposits were situated in thrombotic masses beneath the endocardium, which was sclerosed and increased in thickness but was not infiltrated with calcium

ISSN:1784-3286    

DOI:10.1080/17843286.1958.11717525

出版商:Taylor&Francis    

年代:1958

数据来源: Taylor