摘要:

Conclusions and Summary1. Two groups of patients suffering from myocardial infarction observed by a consultant physician in cardiology, have been the subject of a statistical study. The one group consisted of hospital patients, one other of patients in private practice.2. The object of this study was :a)to conduct research into possible differences in symptomatology of the disease between the two groups;b)to establish, for our area, clinical and electrocardiographic criteria which might serve as the basis for an objective therapeutic study.3. In addition, the influence of two types of therapeutic—with antispasmodics alone or anticoagulants with antispasmodics—has been considered. The critique of this analysis is simple and justifies the importance of the establishment of precise criteria for all future study.4- Besides the classical ideas confirmed by our study, it points out certain facts worthy of interest, common to both groups, such as :a)the similar susceptibility of both intellectual and manual workers to myocardial infarction;b)the low incidence of diabetes in the personal antecedents of the male patients, its higher frequency in women;c)the apparent constancy of the menopause among women suffering from myocardial infarction (98 %);d)the particular frequency of recent anger, also of dyspnea, palpitations, vascular accidents and scapulo-humeral periarthritis in the weeks preceding the accident;e)the almost equal frequency at the onset of the coronary occlusion, of the pain of effort and the pain at rest. The angina appears to be less regular than considered by certain authors;f)besides diverse troubles of rhythm or of conduction, the electrocardiogram brings out evidence of a necrosis in about 87 % of the cases, while lesion and ischemia are observed in 85 % of the patients;g)for the electrocardiographic signs demonstrating the infarction process, the necrosis and ischemia have little tendency to disappear, even after one year; the lesion, itself, persists in a rather great number of cases.5. In hospital cases, there is observed with greater frequency, especially among men : deafness to higher tones, dyspnea, polypnea, stasis pulmonary, hepatomegaly, peripheral oedemas, pericardial friction, bundle branch block, flutter, auriculo-ventricular dissociation, hypotension.These symptoms bring out the great seriousness of most hospitalised cases, a fact confirmed moreover by the respective percentages of mortality.6. Important reservations have been added to the objective value of our therapeutic experiments. It seems, nevertheless, that treatment with anticoagulant, together with antispasmodics, reduces to a significant extent the percentage mortality in the private practice group, equally among men and women.In hospital cases, according to our observations, this beneficial effect has not been demonstrated.7. Our experiences and results indicate us with most clinical research the absolute necessity of perfect standardization among patients made the subject of therapeutic study.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717662

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryThrombolytic agents are enzymes with proteolytic properties against fibrine and other proteins. These agents were since many years introduced in medicine for topical use. It is rather recently that very active thrombolytic substances have been purified and made available for parenteral use in man. Although the therapeutic use of the thrombolytica is being widely explored it is still difficult to define the indications. The first indication seems to be acute arterial occlusions not older than 48 hours and located in—or more distal to the brachial or iliac artery. Acute occlusions of the deep veins of the legs, acute arterial emboli and lung infarct are other indications which are better defined than myocardial infarction and cerebral thromboembolism. Many questions remain unsettled, particularly concerning the route of administration (intravenous or intraarterial), dosage (priming dose or continuous perfusion) and associated medication (hydrocortison, phenylbutazone, chlortrimeton, heparin, coumarin derivatives). The potential dangers, contraindications and antidotes are discussed. The numerous technical requirements for the use of thrombolytic agents are stressed as well. A proper selection of the patients and critical evaluation of the results are recommended.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717663

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryDifferent products are claimed to be thrombolytic. Some of them are activein vitro(fibrinoylsin, urokinase, streptokinase) and others would produce a fibrinolytic activity in the blood after injection (anticoagulants, nicotinic acid, pyrogens, etc.).In order to evaluate the therapeutic value of these drugs in the treatment of thrombo-cmbolic accidents four questions were studied for each product :1) activityin vitro;2) activity after administrationin vivo;3) side effects;4) dissolution of anin vivoclot.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717664

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryLatter years works have thrown a new light on the relationships between the kidney and the adrenal cortex. Beside the well known actions of the corticosteroids on renal excretion of electrolytes, the hormones of the adrenal cortex and the Na content of the diet modify the granularity of the juxtaglomerular apparatus of Goormaghtigh. They control also the amount of renin present in the kidney. Recent works have allowed to localize the renin in the very neighbourhood of the glomerulus and probably in the juxtaglomerular apparatus.Conversely, the renin seems to play a trophic role on the glomerular layer of the adrenal cortex. In the light of these observations, the pathogenesis of arterial hypertension is briefly discussed.If the renin seems to be responsible of the increase of the blood pressure in the acute phase of hypertension of renal origin, this is no more the case in the chronic state. The role of the adrenal cortex for maintaining the hypertension is discussed : several arguments are yet opposed to the idea that the adrenal cortex and particularly aldosterone, may be responsible of the persistence of high blood pressure.Lastly, the protective role of the normal kidney in nephrogenic hypertension is confirmed by the results of the transplantations realized in man.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717665

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryHuman growth hormone was administered in doses of 5 mg daily to a female pituitary dwarf aged 14 years.Marked retention of nitrogen, potassium and phosphorus was demonstrated.There was also some retention of sodium and water. Urinary calcium excretion increased. The level of plasma N.E.F.A. rised markedly.Insulin sensitivity and the rate of glucose uptake by the tissues were reduced but the fasting blood sugar level was unchanged.Studies of long term administration of this growth hormone with particular reference to its effect on height are in progress.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717666

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryDescription of a case of chronic brucellosis characterized by severe anaemia and a bleeding syndrom and hematuria. The only treatment which has entirely successful was the combined chloramphenicol-streptomycin therapy.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717667

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717671

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor