摘要:

SummaryThe dihydrogenated substances derived from ergotoxine and its group have three main pharmacodynamic actions in animals : they depress the central vasomotor tone with consequent hypotension ; they depress the sino-carotid centers sensitive to blood pressure ; they act peripherically as an adeonosympathicolytic agent.By intravenous injection, hydergine (an equal mixture of 3 dihydrogenated alcaloids) is an hypotensive and bradycardia producing agent in man ; this effect is especially definite in cases of arterial hypertension. It produces an orthostatic hypotension, it depresses the hypertension due to epinephrine and the vasopressor effect of the«cold pressor test»(Hines). Attempts of treatment .by hydergine were made in 20 cases of hypertension of various degrees. After two to throe months of treatment 10 to 25 % decrease in blood pressure was observed in 16 out of 20 cases. The control figures of blood pressure were the mean of the lowest figures obtained by usual treatments Subjective symptoms were abolished in 80 % of these cases. No toxic manifestations were observed. A statistical analysis of the data obtained was made with Fisher’sttest; spontaneous changes of blood pressure were taken into account. The results were significative in 14 out of 20 patients, this means that hydergine has a hypotensive action in 70%of the studied cases and that in these the effect due to mere hazard was presumably absent. Study of the coefficients of variation, before and after treatment, shows in most cases a stabilization of the blood pressure duo to a decrease in the paroxysms of hypertension. A definite effect of hydergine on blood pressure was still observed two months after the end of the treatment in 7 outof 16 cases. Hydergine is not t)he ideal drug for the treatment of hypertension, but its use in the therapy of this disease is a definite progress on the usual treatments like sedatives or anti-spasmodics. Any possible effect of the latter has been taken into account in this study.

ISSN:1784-3286    

DOI:10.1080/17843286.1951.11717169

出版商:Taylor&Francis    

年代:1951

数据来源: Taylor

摘要:

SummaryThe possible effects of ACTH on renal tubular capacity to reabsorb glucose have been investigated in 11 patients. There is no reason to think that ACTH modifies the capacity of the renal tubes to reabsorb glucose, or the blood level at which glucose appears in the urine, as J.-W. Conn and collaborators affirmed.In eight of the eleven patients, TmG was measured before the intravenous injection of 25 mgr of«Cortrophin»Organon and from two to four hours after the injection of hormone. The three other patients wore studied before ACTH administration and at the third day of a treatment for rheumatoid arthritis, when 100 to 120 mgr of ACTH were given I. M. No significant change of TmG was noted. No change of the appearance threshold was noticed in the six patients whose threshold values were especially studied.These observations do not agree with the conclusions of J.-W. Conn and collaborators who thought that ACTH decreased the renal threshold for glucose and induced renal glucosuria on the first day of his administration. It is the feeling of the authors that Conn’s conclusions were to hative as he did not use the usual technics of kidney function exploration : i. e. determination of the glomerular filtration rate, and of TmG.It would seem possible to object to our work that the dosage of ACTH used was not sufficient to observe the effects on glucose renal threshold. However it must be noticed that the dosage used was sufficient to decrease the number of blood eosinophils in all cases and to increase the fasting blood sugar level in patients treated for rheumatoid arthritis.At last it will be noticed that the Organon product has a higher biological activity than the ACTH compound generally used by American workers.

ISSN:1784-3286    

DOI:10.1080/17843286.1951.11717170

出版商:Taylor&Francis    

年代:1951

数据来源: Taylor

摘要:

SummaryType A secretory cells (Sluiter and Van Oordt) are found in great number wherever secondary sex characteristics are well developed. In patient Th... in whom the latter are slightly deficient, they are less numerous and mostly localized in isolated and definitely hyperplastic islets of interstitial cells. Well developed interstitial cells, with lipoïdic inclusions, are found in eunuchoid patients in whom the secondary sex characteristics are rarely encountered. Moreover they are definitely localized around the best preserved of the tubules; this is in accord with their presumed trophic role.Biopsy of such testicular lesion may he of interest for another reason. Connections between interstitial elements and nervous fibres should have to ho looked for. This study might improve our knowledge on the possible role of the central nerves system on quantitative and quantitative changes of their secrection.

ISSN:1784-3286    

DOI:10.1080/17843286.1951.11717171

出版商:Taylor&Francis    

年代:1951

数据来源: Taylor

摘要:

SummaryIt is unusual to find many mast cells in the bone marrow. It has been reported in cases of primary and secondary panmyelophtisis, of aplastic anemia, of lymphatic leukemia. We found a large number of mast cells in the hone marrow of a young female aged 21, with hemorrhagic diathesis and splinomegaly since leucopenia, bleeding tendency and infantilism.To our knowledge no similar case has been reported until now.The heparin content of the blood of this patient was within normal limits.

ISSN:1784-3286    

DOI:10.1080/17843286.1951.11717172

出版商:Taylor&Francis    

年代:1951

数据来源: Taylor

摘要:

SummaryWe report a case of a primary carcinoma of the liver in a 27 years old male, where the injection of HI units Insulin resulted in a deep coma with hypoglycemia of 14 ctgr %c.Twenty four and fourty eight hours after the first hypoglycemic incident, the fasting blood-sugar has been found respectively 29 and 47 ctgr%c.Liver post-mortem examination : cirrhosis, hepatoma.This observation, together with similar cases reported in the literature, shows that liver hepatoma can be accompanied by hypoglycemia without any clinical manifestation.The attention is drown upon the great insulin sensitivity in these patients, even with very small doses of insulin.

ISSN:1784-3286    

DOI:10.1080/17843286.1951.11717173

出版商:Taylor&Francis    

年代:1951

数据来源: Taylor

摘要:

SummaryThe authors relate a case of a coaretation of the aerote, found in a young man of 19 years old.An angiocardiography shows a narrowing on the level of the isthma of the norta. The patient has been submitted to a surgial intervention (Crafoord technie). He has been followed during four months after the performation of this operation. The clinical results are completely satisfactory.

ISSN:1784-3286    

DOI:10.1080/17843286.1951.11717174

出版商:Taylor&Francis    

年代:1951

数据来源: Taylor