摘要:

SummaryStimulating the brain, dibenzylmethylamin or Revoxyl may be used with benefit or not in idiopathic narcolepsy - cataplexy or Gelineau’a syndrom. Its advantage consists in being probably devoided of vaso-pressor properties for man as it is the case for animal.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716388

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryRecent biochemical and physiological work has brought evidence of two important groups of corticosterones. The first group characterised by the presence of an O atom on the eleventh C regulates directly carbohydrate metabolism disturbances.Action of the second group (without O atom on C eleven) is directed chiefly against disbalance of plasma ions and their renal excretion. They influence carbohydrate metabolism only indirectly by favouring intestinal absorption of glucides.Dissociated action of different corticosterones in Addison’s disease has been illustrated by very few clinical cases. Only Thorn, de la Balze and Mc Lean have reported three cases of patients who died of hypoglycemia in spite of a long lasting treatment with desoxycorticosterone acetate.Two cases reported here have been closely followed from 1938 during six and seven years, receiving respectively 13 and 18 subcutaneous D. C. S. pellet implants. First case presented severe hypoglycemia on two occasions. Interruption of D. C. S. treatment was responsible for the first hypoglycemic state (1939). Immediate injection of total cortical extracts and glucose quickly restored the situation back to normal.It is actually well known that sterones of the first group are only present in those total aqueous extracts. The second crisis occured five years later. Although blood glucose level was quickly normalised by glucose injections, the patient died in hyperthermic state; as total extracts were not available at that time, strong doses of D. C. S. were used and proved to be uneffective against acute suprarenal insufficiency.Second patient showed no tendency to hypoglycemia even during two severe acute Addisonian crisis, observed before D. C. S. treatment was initiated (1939). Crisis did not recure during the next six years of continuous treatment, but in 1945, routine blood glucose examinations revealed tendency to hypoglycemia after prolonged fasting as well as after absorption of glucose (late hypoglycemia). Increased D. C. S. administration brought partial improvement of the hyperglycemic curve, and reduced both late and fasting hypoglycemia. The effect is believed to result from better glucose intestinal absorption. D. C. S. treatment should not be discarded under influence of recent physiological publications, as sterones of the first group have not yet been synthetized and total extracts remain expensive and must be injected daily. Such extracts are especially usefull in acute crisis not reacting to D. C. S. which however does remain the most practical basic treatment forpreventionof acute episodes. Interest of case two is to show anindirectaction of D. C. S. on blood glucose level and glucose tolerance test notwithstanding its principal effectiveness on ionic disbalance.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716389

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryA deep and prolonged coma lasting hours and days may follow a common insulinic hypoglycemia. It does not respond to glucose injection.This non-hypoglycemic coma seems similar to that appearing during the Sakel method after a serie of comas. In that case the coma also can not be reversed by glucose.Among the factors causing this hypersensibility of the nervous system, as they appear in the three cases reported a bad nutritional state and B2 hypovitaminosis play an important part.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716390

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryInvestigating the basal metabolism of hyperthyroïd patients, the author noticed high combustion«peaks»above the generally increased metabolic rate. Laboratory experiments seem to indicate that those raises are due to the fact that the tissues of the Grave’s disease patients, too much impregnated with thyroïd hormone, become hypersensitive to adrenalin normally secreted by the sympathetic system usual reflexes.The author followed the therapeutic effect of Vitamin A in 28 cases. Very good results have been observed in light, or moderately severe cases. The sympathetic symptoms are particularly improved and the metabolic«peaks»seem to disappear. Experiments on animals suggest that the Vitamin A mainly presents an anti-sympathetic action by decreasing the tissue sensibility to adrenaline and sympathine.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716391

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryTo restore impaired carbohydrate metabolism, sympathicomimetic amines may be used in view of two purposes : either to raise glycemia or to oppose circulatory collapse.To avoid, in case of hypoglycemic coma the administration of substance unnecessarily hypertensive and in case of diabetic coma the administration of drugs dangerously increasing glycemia, we studied the effect of 17 sympathicomimetic amines on the glycemia of man in correlation with arterial pressure.Among these substances, we found two, the hypertensive and hyperglycemic properties of which are definitely dissociated, namely :Stryphnon, which increases glycemia without being hypertensive, and is therefore appropriate in hypoglycemic coma ;Veritol, frequently lowering glycemia ; owing to its reliable effect on blood pressure, valuable as efficaciously opposing collapse in diabetic coma.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716392

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryVitamin A therapy of Grave’s disease has been differently estimated.Vitamin A content of blood of twenty patients with Grave’s disease has been investigated during the period of food limitation. The blood of 54 normal subjects has been examined at the same period. The results are the same in the two groups and hypovitaminosis A has to be discarded in Grave’s disease.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716393

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryThe pulmonary tuberculosis is very frequently associated with a hæmorrhagic diathesis, this seems to be able of promoting hemoptœ, and with an hypoprothrombinæmia, the role of which, however, is scarcely marked. The liver is probably to be accounted but for the genesis of the latter.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716394

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryChanges in specific gravity and hæmoglobin content of human arterial blood during water diuresis *The density of whole arterial blood and arterial plasma was studied in 30 patients, by the technic of Lindeström-Lang. On the same blood specimens the hæmoglobin was measured with the Pulfrich photometer.One hour after ingestion of one liter of water, there is a decrease in density of blood and arterial plasma and also drop of hæmoglobin content.The difference between the density of the blood and that of water at the same temperature decreases about 2,5 %. The corresponding change in density is 3,5 % in the plasma. The reduction in hæmoglobin content is about the same as that of the density of the whole blood (2,73 % as mean of 30 experiments).As, after ingestion of water, the density of the plasma and whole blood drops, there is no doubt that both are diluted. But, if one wishes to express the dilution in terms of increased volume and to relate it to the drop in hæmoglobin content, one has to consider several hypotheses.The first possibility is the blood being diluted by pure water without gaining or losing any protein or red cells. Such conditions being granted, it is easy to calculate that, one hour after ingestion of one liter of water, 100 cc. of arterial blood should contain 2,61 cc. of excess water, distributed in proportion of one fourth in the red cells and three fourths in the plasma.This should be in perfect agreement with the observed changes in density of whole blood and plasma and also with the drop in hæmoglobin content. But in order to prove the concordance between the inference and the facts, one ought to measure by direct observation an increase of 1,39 % in the volume of the red cells, which is hardly feasible by the methods available. Indeed, this would correspond to a very small variation in the diameter of the red cells and to a difference of about 1/200 in the hæmatocrit reading.Other hypotheses might be suggested concerning the mechanism of blood dilution. One might assume that the fluid entering the blood is not pure water but a solution of salts and proteins, or postulate a removal of red cells from the blood after ingestion of water. Such hypotheses are not incompatible with the experimental results. However, they seem to be less probable that the first one and are not easier to prove by direct observation.* The original paper will be published in«Revue Belge des Sciences Médicales»(Louvain).

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716395

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryThe iso-immunisation of a subject of O group against A blood-cells, would transfer the thermal optimum of the normalαagglutinin from 4°to 37°. A case is reported.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716396

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryDescription of a typical case of Waterhouse-Friderichsen syndrome with extensive skin purpura, circulatory collapse, meningical reaction and hypoglycemia. At autopsy, an almost complete hemorrhagical necrosis of the adrenals was found. Cultures of blood and spinal fluid showed meningococcus. The observed symptoms result from meningococcus septicemia and from acute adrenal insufficiency. The role of the adrenals in the pathogenesis of the syndrom, in spite of recent publications, is sure.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716397

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor