摘要:

SummaryFrom 1938 to 1946, 98 cases of lung-abcess were admitted for observation in the medical clinic B (Louvain).Afirst groupof 53 patients were treated without sulphonamides or penicillin.Asecond groupof 45 cases were treated in one of the 3 following ways :a)high and prolonged doses of sulphonamides : 23 cases ;b)alternated sulphonamides and penicillin : 12 cases;c)simultaneous sulphonamides and penicillin : 8 cases.The first group gave 26,5 % of medical successes, while the second group reached 51 %. The total mortality (medical and surgical) was of 21 cases out of 53 in the first group and 11 cases out of 45 in the second.In both groups about half the patients came under observation more than 2 months after the onset of their disease, and one third of the patients showed complications on admission.The best results were obtained in the shortest time in the group treated by simultaneous administration of sulphadiazine or sulphathiazol and penicillin. In that way we obtained 7 satisfactory results out of 8.Actually we consider the following schedule of treatment as the most favourable (for normal adults and with the necessary precautions for a long treatment with high doses of sulphonamides) :1°4 days from 210.000 to 400.000 U. of penicillin + 8 gm. to 12 gm. sulphodiazine p.d. ;2°17 days (at least) 160.000 U. of penicillin + 8 gm. of sulphodiazine p.d.Cases in which the treatment is started late after the onset of the condition are to be treated longer.One should be warned against small doses of sulpbonamides or penicillin, which give no lasting result and may cause the failure of a new medical treatment.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716401

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryThe problem was approached along several lines: hemocultures were made during agony as well as examinations and experiments about body invasion early after deathThe conclusion was that bloodstream invasion by intestinal microbes during agony occurs only in a few instances when the natural immunity is known to be lowered.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716402

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryReferring to a case where a woman suddenly showed flaccid legs paralysis, possible relations between vertebral angioma and hematomyelia are discussed. According to a hypothesis brought forward by the author, in the metamere corresponding to the injured vertebra, the blood vessels of the anterior cells of the marrow be angiomatous ; this condition rending them more fragile, would account for their breaking consequently to an even slight effort.Moreover, the referred patient presents following peculiarities : a limited cutaneous angioma within the same metaniere and some congenital injuries suggesting a constitutional origin of these anomalies.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716406

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryThe aphorisms condense the achievement of twenty five years research on the arrest of hæmorrhage. The constancy of the average«bleeding-time»in the same individual (as in opposition to the diversity of two single bleeding-times) led to a method of studying arrest of hæmorrhage. This permitted to discriminate efficient and inefficient hæmostatics. It proved also to be useful in combining coagulant hæmostatics and those which physiologically increase vaso-constriction produced by wounding. Combined use of both kinds of hæmostatics is to be especially applied to abnormal bleeders whose profuse hæmorrhage depends upon alterations of blood and blood-vessels.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716403

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryMalignant exophtalmos has been observed in two patients suffering from Graves’disease and treated with thiouracil and aminothiazol. Bulging of the eyelids, chemosis and ophtalmoplegia were also noticed. In both cases, thyrotoxicosis had subsided and hypothyroid signs were present when the ophtalmic phenomena supervened. The pathogenesis of the latter is discussed.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716404

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryThree kinds of bronchial abnormalities may be observed by bronchoscopy in silicotic patients : bronchial catarrh, big spurs reducing bronchial calibre, and bronchial spasms. With repeated aspiration of bronchi and direct application of adrenalin upon bronchial mucosa, spasm and catarrh promptly improve, but there is no influence upon the spurs.This treatment diminishes dyspnea very much and for a long time and gives an idea of the importance of bronchial injury in silicotic dyspnea.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716405

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

Summary1. Antibacterial action ofPenicillium Notatumagainst streptococcus viridans has been pointed out by Fleming in bis original studies.2. Clinical experiments in order to treat subacute bacterial endocarditis were started in 1942. However, it was only in 1944 that the first favourable results were published.3. The last two important publications report respectively 30 cases of recovery on 35 and 12 cases on 15.4. It is necessary to have a definite plan of treatment : to know the nature of the responsible micro-organism and its resistance towards penicillin; to give doses which permit to reach adequate concentrations in the blood stream (at least 4 times the value of the resistance of the micro-organism).5. It is interesting to verify the concentration in the serum. If necessary tables may be consulted which give the relations between the injected doses and the concentrations reached in the serum.6. It has recently been pointed out that the natrium salt of para-amino-hippuric acid permits to multiply by 6 the concentration of penicillin in the bloodstream.7. Penicillin may be given by continuous intramuscular or intraveinous injections and by intermittent intramuscular injections. The latter are far the better if they are used every hour or even every other hour. However, if it is necessary to give natrium salt of para-amino-hippuric acid at the same time, continuous intravenous injections must be used.8. The treatment is continued for three weeks. The result is almost always favourable if the concentration in the bloodstream has been well established. In case of failure, a new one is made after having reexamined the resistance of the micro-organism. Furthermore, this time, a concentration in the bloodstream more than 4 times the resistance of the microbe (between 5 and 10 times) must be obtained. Treatment must not be abandoned, even if 5 successive cures remained without result.9. Recurrences must be prevented by exclusion of possible foci of reinfection (nasopharynx, teeth and others). Anti-infectial measures must be taken before, during and after surgical intervention by giving penicillin or if not available sulfamides.If subacute bacterial endocarditis is engrafted on patent ductus arteriosus, it must be tied 15 days after injection has been cured. All these prophylactic measures may be also taken in case of patients who never bad subacute endocarditis but who are susceptible to get this disease.10. Heparin is not a sufficiently interesting factor to justify the additional effort and the risks of hemorrhage implicated by the use of it. Nevertheless, it is used in small doses to avoid apparition of local thrombophlebitis when one is compelled to give penicillin intravenously.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716407

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

摘要:

SummaryThe«cephalin-cholesterol flocculation»test of Hanger has been applied to several groups of patients suffering from hepatic diseases : hepatitis, obstructive jaundice, post-arsenical jaundice and cirrhoses. The tests of Takata, Gross, Weltman, and the dosage of blood phosphatases have been tried on the blood of those patients. The technic of the tests is described and results discussed.In case of hepatitis Hanger test is always positive while Takata, and Gross and Weltman tests give no constant results. The blood phosphatases rise generally to less than 10 U.R. In case of obstructive jaundice Hanger test is sometimes positive (5 times on 15 cases), chiefly when the icterus has lasted for several weeks. In those cases, Takata and Gross tests may also be positive.The blood phosphatases rises generally higher than 10 U.R.Applied to postarsenical jaundices the tests give no conclusive evidence. They are constantly positive in cirrhosis of the liver.An attempt to determine an index of liver damage is proposed, which would allow to differentiate the hepatitis from the obstructive jaundices.

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716408

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1946.11716409

出版商:Taylor&Francis    

年代:1946

数据来源: Taylor