ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718436

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryMediastinal large-B-cell lymphoma with sclcrosis is now considered to be a discrete subtype of lymphoma. It probably originates in the thymus, a T-cell organ. Early publications consider this lymphoma as an aggressive disorder with poor prognosis We studied retrospectively ten consecutive patients with mediastinal B-cell lymphoma with sclcrosis seen in the department of hematology. Nine were women. The median age at diagnosis was 38, 3 years (16–60). Dyspnea (experienced by 7 patients), chest pain (5) and cough (10) were the most common clinical features at presentation. Superior vena cava syndrome occurred in three patients. Five had infiltration of the chest wall or of the pulmonary tissue. Four patients were in clinical stage I (all bulky>10 cm), four in stage IIE, one was in stage IIE and one in stage IV (Ann Arbor classification) . All patients were treated with intensive chemotherapy, mostly containing cyclophosphamide, doxorubicin, vincristine or vindesine, bleomycin and prednisone, combined with etoposide or teniposide and methotrexate. Nine patients responded well to chemotherapy (tumor reduction>75%). One patient progressed. Eight patients received involved field radiotherapy (36–40 Gy) after chemotherapy. The two other patients were treated with intensive chemotherapy (BEAC, BCNU, etoposide, cytarabine, cyclophosphamide), followed by autologous bone marrow transplantation. Two patients died: one patient received autologous bone marrow transplantation in partial remission and relapsed after 6 months; the other patient had progressive disease despite chemotherapy, surgery and radiotherapy. Mean follow-up is 54, 6 months (15–118) with 8 patients still remaining in complete remission.

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718437

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryThe mode of contamination, presentation, clinical evolution and liver histology of 10 native Belgian patients with chronic hepatitis B likely due to a peculiar viral strain, the so called precorc mutant hepatitis B virus were reviewed. This viral strain first described in Southern European regions is characterizxd by a mutation of a single base change at nucleotide 1896 in the preterminal codon of the precore region which creates a stop codon that prevents the production of HBeAg. In this setting, abnormal liver biochemistry and active viral replication as evidenced by IIBV DNA positivity often coincides with a serological profile similar to that observed in healthy HBsAg carriers. Our data indicate that chronic hepatitis related to such a viral strain may be observed in a native Belgian population. This unusual presentation of chronic hepatitis B should thus be kept in mind when interpreting atypical sero-biochemical features, evaluating the risk of infectivity and the potential benefit of antiviral therapy.

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718438

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryThe National Institute for Insurance of Disease and Disablement (RIZIV/INAMI) in Belgium reimburses the costs of long term oxygen therapy (LTOT) by concentrators since 1984 and by liquid oxygen since 1988 for specific categories of patients supervised by approved medical centers. Since then we prescribed these therapies for 83 patients (49 with COPD, 12 with lung fibrosis, 22 with miscellaneous diseases). Since 1984 40 concentrators were prescribed of which 34 have been installed and 11 were still operating in July 1992 at the end of the study: 12 patients died, 2 stopped LTOT and 10 switched to liquid oxygen. Since 1989 43 patients started with liquid oxygen systems, together with the 10 patients who switched from concentrators to liquid oxygen, thus S3 liquid oxygen systems had been described and 46 were still in use in July 1992: 5 patients died and 2 stopped LTOT patient characteristics at entry were: age 62±11 years (mcanilSD), Pa0250±6 mmHg, PaC0247±10 mmHg, polycythemia in 12%, clinical right heart failure in 47% and ECG signs of right ventricle hypertrophy in 70%. Two year survival was 75% for the whole group and 60% for the COPD patients. In patients with COPD improvement of Pa02 (on air) after 1 year of LTOT (+10±8 mmHg in survivors versus 0±6 mmHg in non-survivors) was significantly related to survival (p<0.05). Significant differences between the first

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718439

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryTwelve-lead electrocardiogram were studied in 40 consecutive patients with angiographic left main coronary artery disease. The ECG were analysed during chest pain. The most frequent pattern was a ST elevation (>0.1 mV) in lead aVR alone or with ST depression (>0.2 mV) in the anterior or lateral leads. In coronary artery disease patients, the 12-Iead electrocardiogram at rest remains the best test to dctcct patients at higher risk for massive myocardial infarction or death.

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718440

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryPituitary apoplexy is a rare but sometimes dramatic complication of pituitary tumors. We report the case of a 64-year-old man with a macroadenoma who complained of a sudden and intense headache after a dynamic TRH (200 fig) and GnRH (100 fig) test. Two days later, he presented, an acute ophthalmoplegia with fever and deteriorating consciousness. Emergency CT scan showed contrast hypofixation compatible with necrosis of the adenoma. Surgical, tumoral decompression resolved quickly almost all symptoms. Immunohistochemical study of the tumor confirmed the diagnosis of gonadotropinoma. Several similar cases of pituitary apoplexy occurring after TRH or GnRH tests have been described the last ten years. As this test may sometimes confirm the diagnosis of gonadotropinoma, it should be performed with caution in cases of clinically non functioning pituitary macroadenoma.

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718441

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718442

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718443

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718444

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718445

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor