ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717854

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryVariability of blood pressure was studied in patients with normotension and hypertension. Supine blood pressures were recorded automatically with Arterio sonde (type 1217). Validity of the method was tested by recording blood pressure simultaneously with the mercury manometer and with Arteriosonde. Correlation coefficient for systolic and diastolic readings were 0.97 and 0.93 respectively. Blood pressure variability was calculated in three groups of 15 hospitalized patients: patients without cardiovascular diseases, patients in the third week of hospitalization for myocardial infarction and hypertensive patients. The higher the level of blood pressure, the higher was the variability of this pressure. However, when variability was expressed as the variation coefficient, the data in the three groups were no longer significantly different from each other. Finally it was shown that beta blockade with propranolol (160 and 320 mg/day) was unable to diminish variability of blood pressure recorded over a 24 hours period.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717855

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryIn 63 patients with uncomplicated essential hypertension plasma renin concentration and renal plasma flow were determined under metabolic ward conditions. Sodium intake was limited to 60 milliequi-valents per day. Patients remained under surveillance for an average period of 54 months.Major cardiovascular complications were observed in 11 subjects (myocardial infarction in 7, stroke in 4). Six of these had low renin hypertension. The claim that low renin hypertension represents a relatively protected condition could therefore not be supported. Nor were these subjects less vasocon-stricted than those with higher renin levels.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717856

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryThe normal range of plasma renin activity (PRA), renin concentration (PRC) and aldosterone concentration (PAC) were determined by an active belgian population on an ad libitum and a low sodium diet. No significant changes were found in PRA, PRC and PAC when the sodium intake ranged from 100 to 300 mEq. If the urinary sodium excretion was below 50 mEq/24 h PRA, PRC and PAC increased significantly.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717857

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryFour female and 2 male chronically nephrectomized human subjects were submitted to incremental infusions of angiotensin II before and after selective sodium depletion. The latter was achieved by dietary sodium restriction (potassium intake remaining constant) combined with weight-reducing haemodialysis. In all 6 patients, this procedure resulted in significant falls in mean blood pressure, in serum sodium concentration and in body weight, whereas serum potassium concentration was unaltered. Plasma renin concentration was within the normal range in 5 patients. Plasma angiotensin II concentration was within the normal range in all cases. Both renin and angiotensin II concentrations were unaltered by selective sodium depletion.When angiotensin II was infused intravenously at doses of 1, 2, 4 and 8 ng kg min for Heach, pressor dose-response curves were obtained by plotting the increases in mean blood pressure against the log of the corresponding arterial plasma angiotensin II concentrations. The curves obtained prior to and after sodium depletion were not significantly different.However, when absolute figures of mean blood pressure were plotted against the corresponding plasma angiotensin II concentrations, a downward shift of the curve was observed after sodium depletion. In other words, the relationship between angiotensin II and blood pressure remained the same after sodium depletion, but it took place at a lower baseline level.These relationships were compared with 2 other sets of data, namely those obtained from 5 normal subjects during incremental angiotensin II infusions before and after sodium depletion, and those obtained from 51 patients with renal hypertension after 3 days on a fixed 150 mEq sodium/day intake (21 cases) or on a normal ward diet (30 cases).In the first instance, it was observed that normal subjects, in both sodium replete or sodium deplete states, displayed a mean blood pressure-angiotensin II relationship not significantly different from that obtained in sodium-depleted anephric patients.When spontaneous values of plasma angiotensin II concentration in the 51 hypertensive patients were plotted against the corresponding basal mean blood pressures, the slope of the curve was not different from that obtained in the other groups, but the intercept was significantly higher. These data suggest:1) That sodium depletion“per se”is not able to alter pressor responsiveness to intravenously infused angiotensin II.2) That the relationship between angiotensin II and blood pressure is essentially the same in the different groups studied, but takes place at different basal blood pressure levels.3) That sodium status may be important in determining this basal level is shown by the fact that sodium-replete anephrics are intermediate between the regressions for normal and hypertensive subjects.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717858

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryThe results suggest an important role of the renin-angiotensin system in the forms of arterial hypertension characterized by a state of vasoconstriction. The absence of correlation between the reduction of renin secretion and the lowering of blood pressure under the action of the betablocking drug can at least partially be explained by changes in cardiac output (other actions e.g. lower of the orthosympa-thetic tone at the level of the central nervous system, cannot be exclued).

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717859

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryThe effect of a combined beta-blocking agent-diuretic therapy on blood pressure and renin-angiotensin has been avaluated. Two protocols have been used in 20 hypertensive patients. In the first one, the diuretic has been administered after a maximum dose of betablockade and in the second, beta-blockers have been given after a constant dose of diuretic. In both cases, the addition of the second drug produced a further fail in blood pressure. Physiopathologically, the drugs are compatible, because the stimulation of the renin-angiotensin-aldosterone system induced by diuretics is countered by beta-blockers.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717860

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

SummaryNumerous diuretic drugs are now available. They can be divided into three major groups: thiazids and analogs, diuretics of the Henle loop, and potassium sparing diuretics. Each group is characterized by specific properties as far as the diuretic effect and the clinical use concern. Thiazids are largely used in chronic management of cardiac failure and hypertension. Diuretics of the Henle loop are the first choice drugs in acute cardiac failure and in patients with renal failure. The use of potassium sparing diuretics, in our opinion, should be limited to clinical situation where potassium depletion has to be avoided.

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717861

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717862

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1977.11717863

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor