ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717064

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryAn accidental chlorine gas leakage in a chemical plant in the vicinity of Ghent permitted us to observe the effects on 14 patients within the first 30 hours, and to perform pulmonary function tests.We obtained a 3 month follow-up. We were particularly interested in the acute and subacute changes after the exposure.The accident was provoked by the uncoupling of a chlorine gas pipe situated on an inner court. A yellow-green cloud formed in which the workers stayed between 3 and 30 minutes.Twenty-two workers were involved in the accident, but only fourteen could be fully observed.They were admitted to the emergency room within the first eight hours after the accident.On admission they received oxygen (51/min.) with an oxygen mask during 3 to 6 hours. One heavily exposed worker received antibiotics and stayed for one week in the hospital; the others could leave the hospital after the first pulmonary function tests.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717065

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryHydroxylysine is a typical amino acid of the collagen molecule. Excreted predominantly as two glycosides glucosyl-galactosyl-hydroxylysine and galactosyl-hydroxylysine, it may be considered as a good index of collagen metabolism and allows better than hydroxyproline to understand some structural modifications of the collagen molecule in diseases.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717066

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryThe complement system is activated via two pathways: the classical pathway which comprises C1, C4 and C2 activation and the alternate pathway in which properdin. C3 and factors B and D are implicated. Complement activation by the classical pathway is induced by Ag-Ab complexes whereas the alternate pathway can be activated by other substances such as polysaccharides. Both pathways lead to the activation of C3 and of the last complement components (C5 to C9).Congenital complement deficiencies affect mainly C1 esterase inhibitors, Clq, Clr, C2, C4, C3, C3b inactivator, C5, C6 and C7. Some of these deficiencies are very well supported by the patient whereas others generate a higher susceptibility to infections, glomerulonephritis and lupus syndromes.Acquired deficiencies of the complement system are always the consequence of other pathological phenomena. Most often they are characterized by a low level of the complement components which are decreased during an activation of the complement system via the classical pathway. In all probability, they are the result of an activation of the complement system by Ag-Ab complexes.Activation of the complement system can be systemic as in SLE, or localized in some extra-vascular fluids such as synovial fluid in the joints of patients suffering from rheumatoid arthritis.In some kidney diseases, the complement profile suggests that there is an activation of the complement system via the alternate pathway.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717067

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryA case of acute renal insufficiency after rifampicin reingestion has been described. This occurred with a patient, who had previous been treated with a long-term daily regimen. The interruption period—i.e. time between the last two ingestions—Was 35 months. Such a long interruption period has hitherto not been reported to our knowledge. Haemodialysis was necessary, and resulted in full recovery. Twelve months later rifampicin-dependent antibodies were still present.Since the introduction of intermittent rifampicin therapy, serious side effects have been reported, such as thrombocytopenia, haemolysis, hepatotoxicity and acute renal failure. More recently, several cases of acute renal insufficiency after a break in a daily treatment have been described. In most cases therapy was interrupted for some days, rarely for months. Antibodies to rifampicin could be found in the cases tested and immune complexes may play an important role in the occurrence of these lesions.It is stressed that intermittent rifampicin treatment and every renewed therapy—even after a long interruption period and whatever the first regimen was (daily or intermittent)—may have serious complications.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717068

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryA patient with acute leukaemia developed acute renal insufficiency due to hyperuricaemia before initiating antimitotic therapy.Correction of hyperuricaemia and reappearance of diuresis were obtained by intensive hae-modialysis therapy.Reversibily of such situations is emphasized, as well as the importance of preventive measurements (allopurinol, intensive hydration).

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717069

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryThe physiopathological basis of airway closure and of an increased closing volume is explained as well as its consequences on gas exchange. Also the various situations in which airway closure may be increased, are discussed. It is stressed that an increase in airway closure is not,equivalent with small airway disease.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717070

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

摘要:

SummaryThe standard low-dose of heparin for the prevention of deep-vein thrombosis in operated patients is 5,000 units subcutaneously 2 hours before operation and at 8 or 12 hourly intervals for the next seven days.Low-dose heparin can at present be recommended as an effective agent in the prevention of deep-vein thrombosis in patients over the age of 40 years who are undergoing a major abdominothoracic or gynaecological operation. There is reasonable evidence that low-dose heparin also offers satisfactory protection against fatal embolism for patients at high risk after general abdominothoracic operations. The evidence on the effectiveness of low-dose heparin in the prevention of deep-vein thrombosis is less well established in other groups and particularly in high risk patients e.g. after urologic operations (suprapubic prostatectomy) and hip operations. This important distinction must be made in terms of the population at risk and the efficacy of low-dose heparin.Considering the evidence so far available, it appears that the post-operative state in which dextran has been shown to reduce the incidence of less phlebographically confirmed less deep-venous thrombi most convincingly is orthopaedic surgery. Major orthopaedic surgery is precisely the type of surgery in which the superiority of low-dose heparin is controversial. Unless proven otherwise, dextran 70 (infusion of 500 to 100 ml of a 6% solution started before operation, and 500 ml the following and next 3 alternate days) may be the agent of choice in preventing deep-venous thrombosis in major orthopaedic surgery. Using this scheme the prophylaxis of post-operative deep-vein thrombosis appears as effective with dextran 70 as with oral anticoagulants. Whether the protection offered by dextran 70 will also prevent fatal and non-fatal pulmonary embolism is still an open question.Low-dose heparin and dextran do not expose patients to serious risks of bleeding after operation, and with the recommended doses of the latter drug, other untoward effects are rare. At the doses recommended here neither of these two drugs requires laboratory monitoring.

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717071

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717072

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1976.11717073

出版商:Taylor&Francis    

年代:1976

数据来源: Taylor