摘要:

SummaryThe author summarizes the complicate scheme of spontaneous hemostasis which involves the platelets as well as plasmatic and vascular factors. Their respective role in the pathogenesis of the various hemorrhagic disorders is far from being defined.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717637

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

Summary1) Bleeding determination in grave hemorrhagic states is superfluous and may even be dangerous for the patient.2) If the bleeding time is measured accurately by a trained physician By puncture of both ears and if the results are statistically analyzed, it may give useful information for minor or latent hemorrhagic conditions.3) When measured in these conditions, this test may be helpful to evaluate the effectiveness of a hemostatic therapy.It would be useful to use it together with a test allowing to determine in patients an increased tendency to bleed.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717638

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryThe factors that serve to maintain a normal vascular resistance are largely unknown. Yet, pathological vascular fragility may be semi-quantitatively determined by the tourniquet-test or the suction-cup test. These tests even allow to draw certain conclusions concerning the pathogenesis of the hemorrhagic disorder. Nevertheless the clinician must be aware of their limitations and submit the results to a critical evaluation, especially because of their variability.Tissue biopsy is extremely useful for the making of a diagnosis, in the hemorrhagic conditions where there is neither coagulation defect nor platelets anomalies.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717639

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryThe tests of platelets adhesiveness to glass are not easily applied to clinical problems, because many factors are involved in this phenomenon and there is lack of agreement between the authors concerning the meaning of these tests. They seem to detect anomalies of the coagulation only and therefore it is not justified to use them to measure the tendency of a patient to bleed, as platelets tend to adhere to sub-endothelial structures and therefore to stop the bleeding. Owing to lack of valid statistical data, it is presently impossible to evaluate if this test is a reliable laboratory guide to determine the propensity to thrombo-embolic complications.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717640

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryThromboelastography is a method of choice to follow the coagulation process. It allows an accurate study of the coagulation time and may be truly considered in this respect as a photometer of coagulation. Information is available concerning qualities of the clot, which are not accessible by other methods. Yet it will not take the place of classical coagulation tests, which are indispensable to the detailed study of the other phases of the coagulation process. In the experimental field, thromboelastography is extremely helpful in the study of the physiopathology of the platelets and of the clot structure.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717641

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryA survey is given of the technique of dosage of prothrombine, factor V, VII and X. The applications of those dosages is done in various cases of liver pathology : hepatitis, cirrhosis and obstructive jaundice. The test of Koller used in the differential diagnosis between hepatitis and obstructive icterus is also discussed.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717642

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

Conclusions And SummaryThe Thrombotest reagent shows a remarkable buffering capacity at the normal blood pH and shares its electrolytic composition (Na, K, CI) except for the absence of bicarbonate. The activity of the clotting factors I, V and VIII is high in contrast with a moderate Fe(II) and Cu (II) content. The stability of the reagent in suspension is excellent at - 30°C (at least during 30 days) and good at +4°C (maximum during 7 days); the Thrombotest rea-gent can hence be stored and avoids occasionally the need of a control blood sample. The test has to be performed strictly at 37°C because of its sensitivity to minor temperature differences. The reagent is easily brought into suspension, the results obtained do not differ significantly if the CaCl2solution is between 3.3 and 5.5 mM/1. The test is easily standardized since the dilution fluid used has not to be defined so strictly as for the usual commercialized tissue thromboplastin. The Thrombotest is a real progress if capillar blood is used. Activation phenomena in citrated blood are still minimized problems in the use of Thrombotest on stored blood or plasma. One of the advocated advantages of the Thrombotest method would be its sensitivity to factor IX and hence to the intrinsic clotting system. However, this last point is not completely proved and stimulates further investigations.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717643

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryThe anticlotting activity of a physiological heparin-like substance can be demonstrated by the study of dilution curves of fresh blood in non wettable material.The usual clotting tests appear unequally sensitive to the presence of an anticoagulant as far as the site and mechanism of action of the inhibitor and the interference of compensatory reactions are concerned. The procedures should be improved by using non wettable surfaces, reduced activators and concentrated inhibitor.The use of several methods is advisable for detecting abnormal inhibitors.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717644

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryA general discussion is given of the significance of fibrinolysis as a hemorrhagic syndrome observed in patients with shock, cancer, premature separation of the placenta, etc. The factor of anoxemia appears to be determining in the appearance of fibrinolysis.Production of fibrinolysis in patients with thrombotic and embolic diseases represents a new thrombolytic therapy. It should be based on a correct understanding of the enzyme system and proper use of laboratory determinations.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717645

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor

摘要:

SummaryThe methods used to determine blood fibrinolytic activity are of two main types :a) Methods using patient’s blood (or some of its fractions) as substrate :—thrombolysis of diluted or undiluted whole blood, observed by simple inspection or measured by thromboelastography;—fibrinolysis of a clot formed from total or diluted plasma by observation of total fibrinolysis or progressive disappearance of the clot;—measurement of lysis-time of euglobulins.b) Methods where the substrate is not a component of patient’s blood but :—plasma or some other blood fraction from another individual;—casein (radioactive or not);—gelatin;—esters such as LEe, TAMe, etc.A simple method, which can be used in any laboratory, is presented. Used in conjunction with a rapid fibrinogen determination, it is useful for thrombolytic therapy or in the treatment of haemorrhage due to fibrinolysis.

ISSN:1784-3286    

DOI:10.1080/17843286.1961.11717646

出版商:Taylor&Francis    

年代:1961

数据来源: Taylor