ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718471

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryEpidemiological data were collected for 219 cases of neonatal septicaemia and/or meningitis. In two thirds of the cases the diagnosis was made in newborns aged 4 days or less. Risk factors related to the delivery, to the health status of the infant at birth and to pregnancy were mentioned respectively in 74, 63 and 36 % of the cases. Half of the newborns given antibiotics in prophylaxis received an association of aminopenicillin and aminoside. In more than four fifths of the cases the bacterium was only isolated from blood. In newborns aged 4 days or less at the lime of diagnosis,S. agalactiaewas the most frequently isolated agent (50%). In newborns aged 5 days or more at the time of diagnosis,E. coliwas the most frequent isolate (23%), followed byS. agalactiaeand coagulasc-negativeStaphylococcus(20%). The lethality was 18%. About three fourths of the children dying from the infection, died during the first week of life. For the children who did not die during their stay in hospital, the duration of hospitalization was longer than 4 weeks in 41%.

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718472

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryWe investigated a group of Belgian HCV-100 Elisa positive volunteer blood donors for potential sources of contamination and the presence of liver biochemical abnormalities. In addition, results of serological testing and liver biochemistry of their related blood products recipients were also analysed.In blood donors, anti-HCV-100 repeat reactive rate was 0.77% with a 34% rate of abnormal liver function tests. A potential source of parenteral exposure was found in all donors with RIBA-confirmed HCV-100 positivity.Among recipients, anti-HCV-100 RIBA-2 positive blood product donations were associated with RIBA-2 seroconversion, a history of transfusion in donors being of high predictive value of infectivity.

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718473

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryThe use of heparin may be complicated by two types of thrombocytopenia (HAT): type I occurs early, is transient, and has no clinical relevance, while type II may lead to very severe manifestations (arterial or venous thromboses and more rarely bleedings), that are still underestimated by some clinicians. HAT-type II most frequently develops after use of therapeutic doses of unfractionalcd heparin (UH) but has also been described less frequently after use of very low doses of UH, of low molecular weight heparins (LMWH), and even of polysulfated glycosaminoglycosans devoid of anticoagulant action.The estimation of the incidence of HAT-type II and of related thromboses is a very difficult matter. Recent observations suggest that thromboses (notably venous) may be more frequent than previously estimated.HAT-type II pathophysiology includes the formation of immune complexes at the surface of platelets; the antigen has been shown to be most often platelet factor 4 bound to heparin while the antibody is recognized by platelet FcyRII receptors. Thromboses result most probably from activation of both platelets (leading to the formation of microparticles) and endothelial cells.Several biological tests are presently available for diagnosing HAT-type II but none of them has been shown to be-ideal.The prevention of HAT-type II requires history taking preference of LMWH to UH, early start of oral anticoagulation, and platelet monitoring from the fifth day of heparin therapy.The therapy of HAT-type II implies immediate discontinuation of heparin and avoidance of platelet transfusions, unless severe bleeding occurs. If further antithrombotic treatment is deemed necessary (probably in all cases), several options are possible but presently, the most recommended ones are Org 10172 or Ancrod; embolectomy or thrombolysis may also be required if a new thrombotic event has developed. A very difficult dilemma concerns patients previously sensitized to heparin and who present a clinical situation that theoretically mandates re-exposure to UH, such as by-pass surgery; prostacyclin analogues may be successfully used in such cases. Recent developments in the therapy of HAT-type II include recombinant hirudin or synthetic analogs, or use of some intravenous immunoglobulin preparations. Possible candidates are the heparin synthetic pentasaccharide and recombinant tissue factor pathway inhibitor.

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718474

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryOchronosis is a rare disease caused by an inherited lack of homogentisic acid oxidase. Alkaptonuria is the presence of homogentisic acid in urine. Ochronosis is characterized by the deposition of a dark pigment in tissues rich in collagen. A wide spectrum of clinical manifestations is described. The most important signs are ochronotic arthropathy, ocular and cutaneous pigmentation, genitourinary tract obstruction by ochronotic calculi and cardiovascular ochronosis, especially calcification and stenosis of the aortic valve. The constellation of these clinical signs should suggest the diagnosis which is confirmed by the detection of homogentisic acid in urine. There is no cure for the disease and treatment is based on symptomatic measures.

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718475

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

SummaryWc report Ihe case of a 73-year-old man, who developed acute renal failure in association with aLegionella pneumophilaserotype 1 pneumonia. Renal biopsy revealed a tubulointerstitial nephritis. Treatment with erythromycin, rifampicin and haemodialysis resulted in a clinical resolution of the pulmonary and renal syndromes.

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718476

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718477

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1995.11718478

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor