ISSN:1784-3286    

DOI:10.1080/17843286.1992.11718269

出版商:Taylor&Francis    

年代:1992

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1992.11718270

出版商:Taylor&Francis    

年代:1992

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1992.11718271

出版商:Taylor&Francis    

年代:1992

数据来源: Taylor

摘要:

SummaryWhile obesity is frequently associated with arterial hypertension, the underlying mechanism is still poorly understood. A marked drop in blood pressure in response to hypocaloric carbohydrate-poor diet, occurring usually in obese hypertensive patients even before any significant reduction of body weight is achieved, strongly suggests that the obesity related metabolic abnormalities rather than the degree of fatness as such, are involved in the association between obesity and overweight. Among several possible mechanisms, the state of insulin resistance with hyperinsulinaemia, as well as increased activity of the sympathetic nervous system, are probably responsible for the development of arterial hypertension in obese subjects. The arterial hypertension may be promoted by these two mechanisms, which are probably causally related, closing the pathophysiologic loop leading to hypertension. Both mechanisms may promote the development of haemodynamic abnormalities which characterize the hypertension associated with obesity, i.e. the renal sodium and fluid retention with ensuing expensionoftheextracellularvolumeandthe increased peripheral vascular resistance.

ISSN:1784-3286    

DOI:10.1080/17843286.1992.11718272

出版商:Taylor&Francis    

年代:1992

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1992.11718273

出版商:Taylor&Francis    

年代:1992

数据来源: Taylor

摘要:

SummaryObesity is a well-known risk factor for the development of non-insulin-dependent diabetes mellitus (NIDDM). Both insulin resistance and concomitant B-cell dysfunction are necessary for the development of NIDDM. Insulin resistance, probably genetically determined but worsened by obesity, appears to be the primary defect that leads to impaired glucose tolerance. However, B-cell dysfunction plays a critical role during progressive deterioration from mild impaired glucose tolerance to severe NIDDM.

ISSN:1784-3286    

DOI:10.1080/17843286.1992.11718274

出版商:Taylor&Francis    

年代:1992

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1992.11718275

出版商:Taylor&Francis    

年代:1992

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1992.11718276

出版商:Taylor&Francis    

年代:1992

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1992.11718277

出版商:Taylor&Francis    

年代:1992

数据来源: Taylor