ISSN:1784-3286    

DOI:10.1080/17843286.1996.11718479

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryIn ihe trcalmenl of patients with primary biliary cirrhosis (PBC), methotrexate (MTX) and ursodeoxycholic acid (UDCA) have both been associated with clinical, biochemical, and histologic improvement. Studies with methotrexate have only been performed in uncontrolled conditions. We conducted a prospective controlled study on the combined treatment with methotrexate and ursodeoxycholic acid, comparing the clinical, biochemical, and histologic evolution in six untreated patients with that in eight patients treated with MTX 15 mg/week in association with UDCA 500 mg/day. All patients had non-cirrhotic PBC and were followed up for two years.A significant decrease of alkaline phosphatase, glutamic pyruvic transaminase, and gammagluta-myltranspeptidasc was found in the methotrexate/ursodeoxycholic acid treated-group, as compared to the control group. The clinical and histologic evolution, however, was not significantly different in the two groups. Methotrexate toxicity consisted of interstitial pneumonitis in one, of a transient rise of transaminases at three months in five, and of a significant decrease of blood platelets and white blood cells alter two years of treatment.In controlled conditions, a two-year treatment with methotrexate and ursodeoxycholic acid does not produce a significant clinical or histologic benefit. Based on this experience, and taking into account the possible risks associated with this therapy, the empiric use of methotrexate cannot be recommended in patients with non-cirrhotic PBC.

ISSN:1784-3286    

DOI:10.1080/17843286.1996.11718480

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryOul of 11 patients suffering fromMycobacterium xenopilung disease, 9 were treated with an empiric antituberculous triple chemotherapy until specific identification and antibiogram were available. Despite the important“in vitro”resistance to drugs, most of the patients improved; in the other patients, the impairment was always due to the underlying pathology. Wc conclude that the“in vivo”response of M.xenopiinfections to antituberculous drugs is little influenced by the“in vitro”sensitivity.

ISSN:1784-3286    

DOI:10.1080/17843286.1996.11718481

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryThein vitroactivity of cefcpimc has been compared with that of cefotaxime, ceftazidime, aztreonam, and piperacillin against 1826Enterobacieriaceaeincluding 537 inducibleEnterobacieriaceae (Entero-bacterspp.,Serratiaspp.,Citrobacterspp.,Morganella morganii)and 572 non-fermenters, including 401Pseudomonas aeruginosaand 111Acinetobacterspp. isolated from hospitalized patients in 28 Belgian hospitals. Overall, ccfepime was found substantially more active than the third-generation cephalosporins, aztreonam and piperacillin againstEnterobacieriaceaespecies producing inducible type I cephalospo-rinases. Notably, cefepime remained active against 96% ofEnterobacieriaceaeresistant to cefotaxime, ceftazidime or aztreonam while it displayed a similar activity againstE. coliand the otherEnterobacieriaceae.Against non-fermenters. cefepime was found less active than ceftazidime but more than cefotaxime or aztreonam.

ISSN:1784-3286    

DOI:10.1080/17843286.1996.11718482

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryThe pathogenesis of Ihe anemia of cancer involves the combination of a shortened erythrocyte survival in circulation with the failure of bone marrow to increase red cell production in compensation. Inappropriate red cell production is itself related to a conjunction of factors, including impaired availability of reticuloendothelial storage iron, inadequate erythropoietin (Epo) response to anemia, and overproduction of cytokines which are capable of inhibiting crythropoiesis. Many of these cytokines may interfere with erythropoietin production by the kidney. Consequently inadequate serum erythropoietin levels are often encountered in cancer patients, though more frequently in those with solid tumors or multiple myeloma than in those with other hematologic malignancies. There is little evidence supporting a negative impact of chemotherapy, including cisplatin, or erythropoietin production. Rather, chemotherapy usually causes a transient elevation of scrum Epo. Red cell transfusions are often administered to cancer patients, possibly resulting, among other deleterious effccts, in enhancement of tumor growth. Recombinant human erythropoietin (rHuEpo) has thus beer proposed as an alternative. RHuEpo has been shown to be safe and effective in correcting the anemia ol cancer and reducing the need for transfusions. The response rate is as good in hematologic malignancies as in solid tumors, but it is extremely poor in those with myelodysplasia syndromes. The effect of rHuEpo docs not differ among patients receiving or nol receiving chemotherapy, including cisplatin. The probability of response is also similar in patients with adequate or inappropriate erythropoietin production

ISSN:1784-3286    

DOI:10.1080/17843286.1996.11718483

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryWe report another case of acute interstitial nephritis with uveitis (TINU syndrome) in a 35-year-old woman. About thirty cases were described since the first ones 20 years ago. We discuss the assessment needed to reach the diagnosis. The evolution is usually favourable with steroid therapy.

ISSN:1784-3286    

DOI:10.1080/17843286.1996.11718484

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

SummaryWe describe two cases of fatal septic shock causcd by Lancefield group G streptococci. Both were community-acquired and occurred in previously healthy adults. Both patients died in severe multiple organ failure despite prompt antibiotic therapy. Serological typing of bacterial cultures identified the T-protein antigen as serotype 300, but this was thought to be of little relevance to the pathogenesis; T-protein antigens are useful as epidemiological markers.M-typing and PCR (polymerase chain reaction) detection of the streptococcal pyrogenic exotoxin genes were found to be negative suggesting that this highly pathogenic organism may represent a new M-type.

ISSN:1784-3286    

DOI:10.1080/17843286.1996.11718485

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1996.11718486

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1996.11718487

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor