摘要:

Summary56 infections episodes in patients with a neoplastic disease were treated by intravenous doxycycline (200 mg per day) ; 37 (66 %) responded favourably to therapy.Minocycline (200 mg per day) (orally) has been effective in the treatment of infections in 35 (77 %) out of 45 patients.In infections caused by sensitive organism, both antibiotics were shown to be an effective therapy ; the rate of clinical failures increased when the causative organism was resistant in vitro ; it is therefore concluded that these antibiotics should not be used in severe infections without testing the sensitivity of the suspected pathogen, chiefly if Gram negative rods are involved, since their sensitivity is less common than for Gram positive cocci.Both antibiotics were well tolerated. A serious complication of treatment with these tetracycline analogues was a high incidence of colonization and superinfection observed in the patients treated.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716847

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryThe study of the susceptibility of 100 strains of Staphylococcus aureus to Tetracycline and Minocycline reveals two different types of resistance for these two antibiotics. Tetracycline susceptibility, when present, is unequivocal. In the contrary, many strains are moderately sensitive to Minocycline ; taking into account the blood levels achievable, this suggests that Minocycline could hardly be an effective drug against such strains.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716848

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryA 36 years-old man, suffering since more than ten years from a severe hemorrhagic recto-colitis (ulcerative colitis) experienced a bad relapse at the beginning of 1972. Treatment with Salazopyrin (Azulfidin) and ACTH proved of no avail. Because of a white cell count of 14,200 it was decided to resort to an anti-infectious therapy : Trimethoprim-sulfamide (Eusaprim) was given in daily amounts of 4 tablets for one week ; afterwards the daily dose was reduced to 2 tablets. Results were spectacular : within three days the diarrhea ceased ant there occurred only a minimal passage of blood after bowel movements. The left colon was no longer tender. Within the next five months the body-weight increased with 6 Kg.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716849

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryLonglasting topical application of Gentamicin, in various skin lesions, induced the appearance of a Pseudomonas aeruginosa strain which was resistant to this antibiotic. Being resistant to more than 100µg/ml of Gentamicin (by disc agar diffusionand broth dilution test tube methods), this strain shows a particular lysotype. The latter may be present in the lesions together with other susceptible lysotypes. The spreading risks of such strains through the hospital wards are serious and question the topical use of major antibiotics. Resistant strans disappeared after antibiotic therapy have been discontinued.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716850

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

AbstractThe influence of storage on the ESR, determinated simultaneously by a method using heparin and citrate solution as anti-coagulants and by the classical Westergren method, was investigated.Blood samples of 16 patients with a full range of ESR’s were stored for different times. Statistical analysis of results allow us to conclude that storage of anticoagulated blood for :1. 6 hours at room-temperature does not alter results significantly.2. 24 hours at room-temperature causes significant slowing of ESR’s.3. 24 hours at 4°C does not result in significant changes.These conclusions apply equally to both methods of ESR determination studies. Both methods are moreover not-significantly different in this respect.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716851

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryExperimental infection by toxoplasma in the mouse has been treated by trimetoprim-sulfamethoxazol association. All animals are survived ; besides that, they have acquired an immunity against a reinfection by the same parasite. The in vitro experiments have demonstrated that this acquired immunity depends on humoral and cellular factors.The clinical experience, even limited, confirms the results of the laboratory. The association trimetoprim-sulfamethoxazol can be proposed as a new therapeutic of the toxoplasmosis.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716852

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

SummaryThe authors review 39 cases of adult patients with accidental hypothermia. The frequency of this affection is presumably higher than generally thought, especially in normal but aged patients and in different pathological conditions which interfere with the mechanisms of thermoregulation. Eventhough the diagnosis of hypothermia is a simple one, it is probably often missed because the symptoms of the causal disease are frequently masking it, but also because the characteristic signs of hypothermia appear only when the temperature is really low (under 33°C).Clinical manifestations of hypothermia are quite various and are largely depending on the causal disease. Shivering, muscular hypertonia, skin modifications, hemodynamic disturbances, bradycardia and bradypnea are usually observed. The authors underline the possible absence of severe alterations of conscience, even when the central temperature reaches 26°C. Biological tests are generally slightly perturbed.The prognosis is closely related to the prognosis of the causal disease. The major complications are hypotension, cardiac arrhythmias, infectious bronchopulmonary complications. Intensive therapy (active or passive rewarming, maintenance of a good circulatory state, artificial ventilation if necessary) and a constant watching of these patients in an intensive care unit are a necessity. In these conditions, and providing that the causal affection is reversible, the prognosis of hypothermia is good, even if the central temperature is deeply lowered.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716853

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

摘要:

Conclusion And SummaryOur study has been performed with precise diagnostic and follow-up criteria in 20 patients hospitalized for pulmonary infection. As a result of this strictly controlled trial we are concinced that minocycline is an antibiotic of great value. This antibiotic, easily administered (two oral doses a day), gave very good results in 80% of the cases, with only minor digestive side-effects in 20 % of the patients.

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716854

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor

ISSN:1784-3286    

DOI:10.1080/17843286.1973.11716855

出版商:Taylor&Francis    

年代:1973

数据来源: Taylor