摘要:

SummaryThe author exposes the most recent experiments in the field of cancer chemotherapy with alkylating agents. He proposes a classification of these substances, using the chemical structure of the prosthetic group as a base for this classification. Recent works have tried to increase the activity of chemo-thcrapcutic agents by synthesizing complexes with a prosthetic group acting, by its chemical structure, as a carrier for the alkyl groups. The purpose is to find a carrier which preferentially it«leads»the active group within the cancer cells. The pioneer work in this field seems to be the synthesis of substances with an aminoacid as a carrier (Salcolysine). In more recent agents, the active group is linked to a pyrimidin, a dipeptide or a polypeptide. In the«dual»antagonists, the same molecule contains the alkyl group and another active substance, for instance urcthane. Cyclophosphamide is inactive in its complex form and would be activated by an enzyme which is particularly abundant in the cancer cells.In the last part the author gives some aspects of the new methods of administration of the alkylating agents, such as arterial catheterization, extracorporeal circulation, chemoprophylaxy and associations with other therapeutic measures.

ISSN:1784-3286    

DOI:10.1080/17843286.1962.11717683

出版商:Taylor&Francis    

年代:1962

数据来源: Taylor

摘要:

SummaryAfter a short review of the main biochemical differences between neoplastic and normal cells, the author describes the essential factors of the synthesis of nuclear tctranucleotides and the different groups of antimetabolites that may disturb this metabolic cycle.The author then analyses the antifolic and antipuric substances that play an essential role in anticancerous chemotherapy.This work ends with a brief outline of the recent progresses realized in the preparation of alkylating metabolites and with the description of a technic which allows the localization in the cancerous tissue of the action of the antimetabolites perfused in the artery, thanks to the contcmporarv I.M. administration of the specific metabolites.

ISSN:1784-3286    

DOI:10.1080/17843286.1962.11717684

出版商:Taylor&Francis    

年代:1962

数据来源: Taylor

摘要:

Summary1. The author studied the age-distribution curves of the different forms of leukemia, on the basis of the National Statistics of Diseases and two series of clinical observations from the University of Ghent (Belgium).2. The acute leukemia is the most frequent form to day. This form is most seen at the age between 3 to 4 years and between it to 13 years. The most cases are actually seen past the fourth decade.3. Only the chronic lymphatic leukemia is more frequent on males. The differences between sexes is rather small, concerning the other two forms of leukemia.4. To-day the incidence of leukemia after the fourth decade seems to increase slowly. This phenomenon is not yet clear understood.

ISSN:1784-3286    

DOI:10.1080/17843286.1962.11717685

出版商:Taylor&Francis    

年代:1962

数据来源: Taylor

摘要:

SummaryThe efficiency of the treatment of leukemia in children must be evaluated taking into account the percentage of total remissions and their duration.According to these criteria, there is a significant statistical difference between three groups of patients treated at three distinct periods by a different treatment.The best results were obtained by the association of prednisone and 6-mer-captopurine, the last drug being administered during remission as a maintenance treatment.

ISSN:1784-3286    

DOI:10.1080/17843286.1962.11717686

出版商:Taylor&Francis    

年代:1962

数据来源: Taylor

摘要:

SummaryThe drug of choice to be used in the treatment of chronic myeloid leukaemia is Myleran. Total clinical and haematologic remissions are generally, obtained.Other antimitotic agents are efficient, especially in Myleran resistant cases. Radioactive isotopes, such as P32 and A1*" can also be used.Due to more protean aspect of the disease, the treatment of lymphoid leukemia is more difficult. The best drug in such a case is chlorambucil, which can be associated with Röntgen therapy in cases with large lymphadenopathies, or with corticoid hormones in cases with anaemia.Other chemotherapeutic agents have been tested, such as Fe3', Dopan, Sarcolysine, Degranol and Endoxan, but none of them seem better than Myleran and Leukeran.

ISSN:1784-3286    

DOI:10.1080/17843286.1962.11717687

出版商:Taylor&Francis    

年代:1962

数据来源: Taylor

摘要:

SummaryMinutes of a clinico-pathological meeting regarding the case of a 60 years old man, having presented during the last 3 years of his life periods of pyrexia of obscure origin. The laboratory examinations only gave limited information. The sedimentation rate was low, leucocytosis was normal but with a relative monocytosis. During the 2 months preceding death, the general condition rapidly deteriorated and an irreductible collapsus appeared. The anatomical-pathological examination revealed the existence of chronic generalized tuberculous adenitis, and lesions of recent tuberculous hematogenous dissemination with among other things a peculiar embolic tuberculous glomerulo-nephritis. The origin of the tuberculous dissemination was an endo-aortic polyp containing very numerous tuberculous bacilli. During the discussion the following points were brought up : the significance of the low sedimentation rate and of the blood formula during the course of the tuberculosis, the explanation of the irreversible collapsus, the role played by the cortisone treatment in the tuberculous dissemination, and the treatment of the tuberculous adenitis.

ISSN:1784-3286    

DOI:10.1080/17843286.1962.11717688

出版商:Taylor&Francis    

年代:1962

数据来源: Taylor