|
1. |
Siting a Hazardous Waste Facility: A Success Story in Retrospect1 |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 3-4
W.E. Harris,
Preview
|
PDF (201KB)
|
|
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00718.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
2. |
“The Mental Model” Meets “The Planning Process”: Wrestling with Risk Communication Research and Practice1 |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 5-8
Branden B. Johnson,
Preview
|
PDF (347KB)
|
|
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00719.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
3. |
Response: Relative Versus Absolute Risk Modeling of Aflatoxin1 |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 9-10
John C. Bowers,
Preview
|
PDF (130KB)
|
|
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00720.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
4. |
Present Crisis and the Future of Alcohol Programs in Brazil1 |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 11-12
Luiz Pinguelli Rosa,
Preview
|
PDF (147KB)
|
|
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00721.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
5. |
Jousting with Environmental Windmills1 |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 13-15
Dennis J. Paustenbach,
Preview
|
PDF (271KB)
|
|
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00722.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
6. |
Note and Comment on “General Deterrence of Drunk Driving: Evaluation of Recent American Policies” |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 17-20
Paul L. Zador,
Adrian K. Lund,
Preview
|
PDF (332KB)
|
|
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00723.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
7. |
Toward Humility in Statistical Interpretation1 |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 21-22
William N. Evans,
John D. Graham,
Doreen Neville,
Preview
|
PDF (144KB)
|
|
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00724.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
8. |
Did the Laws Have an Effect?1 |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 23-23
Paul L. Zador,
Adrian K. Lund,
Preview
|
PDF (67KB)
|
|
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00725.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
9. |
Modeling Receptor‐Mediated Processes with Dioxin: Implications for Pharmacokinetics and Risk Assessment |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 25-36
Melvin E. Andersen,
Jeremy J. Mills,
Michael L. Gargas,
Lorrene Kedderis,
Linda S. Birnbaum,
Diether Neubert,
William F. Greenlee,
Preview
|
PDF (1021KB)
|
|
摘要:
Dioxin (2,3,7,8‐tetrachlorodibenzo‐p‐dioxin; TCDD), a widespread polychlorinated aromatic hydrocarbon, caused tumors in the liver and other sites when administered chronically to rats at doses as low as 0.01 μg/kg/day. It functions in combination with a cellular protein, theAhreceptor, to alter gene regulation, and this resulting modulation of gene expression is believed to be obligatory for both dioxin toxicity and carcinogenicity. The U.S. EPA is reevaluating its dioxin risk assessment and, as part of this process, will be developing risk assessment approaches for chemicals, such as dioxin, whose toxicity is receptor‐mediated. This paper describes a receptor‐mediated physiologically based pharmacokinetic (PB‐PK) model for the tissue distribution and enzyme‐inducing properties of dioxin and discusses the potential role of these models in a biologically motivated risk assessment. In this model, ternary interactions among theAhreceptor, dioxin, and DNA binding sites lead to enhanced production of specific hepatic proteins. The model was used to examine the tissue disposition of dioxin and the induction of both a dioxin‐binding protein (presumably, cytochrome P4501A2), and cytochrome P4501A1. Tumor promotion correlated more closely with predicted induction of P4501A1 than with induction of hepatic binding proteins. Although increased induction of these proteins is not expected to be causally related to tumor formation, these physiological dosimetry and gene‐induction response models will be important for biologically motivated dioxin risk assessments in determining both target tissue dose of dioxin and gene products and in examining the relationship between these gene products and the cellular events more directly involved
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00726.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
10. |
A Physiologically Based Pharmacokinetic Assessment of Tetrachloroethylene in Groundwater for a Bathing and Showering Determination |
|
Risk Analysis,
Volume 13,
Issue 1,
1993,
Page 37-49
Hari V. Rao,
David R. Brown,
Preview
|
PDF (1022KB)
|
|
摘要:
A two‐step methodology is described to make a health‐based determination for the bathing and showering use of the water from a private well contaminated with volatile organic chemicals. The chemical perchloroethylene (PERC) is utilized to illustrate the approach. First, a chemical‐specific exposure model is used to predict the concentration of PERC in the shower air, shower water, and in the air above the bathtub. Second, a physiologically based pharmacokinetic (PBPK) model is used to predict the concentration of PERC delivered to the target tissue, the brain, since the focus is on neurological endpoints. The simulation exercise includes concurrent dermal and inhalation routes of exposure. A reference target tissue level (RTTL) in the brain is estimated using the PBPK model. A hazard index based on this benchmark guideline is used to make a regulatory determination for bathing and showering use of the contaminated
ISSN:0272-4332
DOI:10.1111/j.1539-6924.1993.tb00727.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
|