ISSN:0886-022X    

DOI:10.3109/08860229609047699

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0886-022X    

DOI:10.3109/08860229609047700

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

Different adhesion molecules are implicated in the pathogenesis in glomerulonephritis. Leukocyte adhesion molecules play a critical role in causing renal damage in a variety of glome rulonephritic conditions. In order to understand the mechanisms by which distinct adhesion molecules are involved in human glomerulonephritis, it is necessary to have an overview of their function in maintenance of tissue architecture, morphogenesis, immunosurveillance, inflammation, tumor growth, etc. Thus, this review addresses the role ofcad-herins, selectins, integrins, and members of the immunoglobulin supergene family in developing, normal, and diseased kidney with special attention to glomerulonephritis and possible new therapeutic approaches.

ISSN:0886-022X    

DOI:10.3109/08860229609047701

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0886-022X    

DOI:10.3109/08860229609047702

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0886-022X    

DOI:10.3109/08860229609047703

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0886-022X    

DOI:10.3109/08860229609047704

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

The renal biopsy plays an important role in the clinical evaluation of patients with lupus erythematosus. From numerous studies of renal biopsies in lupus nephritis, it has become clear that although the renal lesions are quite varied, the pattern of renal involvement correlates with the clinical outcome. The broad spectrum of lesions seen in lupus nephritis has been attributed to individual differences in the immune response in different patients or in the same patient during the course of disease. Classification of lupus nephritis authorized by the World Health Organization has provided a standardized approach to the findings on renal biopsy. This classification combines all of the morphologic modalities of biopsy interpretation including light, immunofluorescence, and electron microscopy as well as providing a semiquantitative assessment of activity and chronicity. The clinical correlations utilizing this histologic classifications have demonstrated that the specific nature of the renal histopathology can predict both the acute and long-term outcome of the renal disease in patients with lupus erythematosus and can be useful in determining the management of individual patients.

ISSN:0886-022X    

DOI:10.3109/08860229609047705

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0886-022X    

DOI:10.3109/08860229609047706

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

Patients with systemic vasculitis (SV), especially Wegener's granulomatosis and microscopic polyangütis, regularly present with renal involvement. Although considered a rare disease, either the incidence of SV is increasing or it is being increasingly recognized. Accurate classification systems are required to allow comparison of data from different groups investigating and treating these patients. Systemic vasculitis is known to be an autoimmune disease, but the mechanisms of pathogenesis have not been established, despite many studies on this topic in recent years. Most of this work has been done in vitro, although development of animal models is underway. Patient and renal survival have improved with aggressive immunosuppressive treatment, but morbidity is high and controversies remain in establishing the most effective regimens with minimum adverse effects. In this review we discuss the classification of SV, review the current knowledge of pathogenic mechanisms, and consider the relative merits of different treatment protocols.

ISSN:0886-022X    

DOI:10.3109/08860229609047707

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

Antineutrophil cytoplasmic antibodies (ANCA) constitute a family of autoantibodies directed against various components of the neutrophil cytoplasm. Their identification and association with vasculitis and rapidly progressive glomerulonephritis has led to considering these diseases as possible autoimmune disorders. In addition, ANCAs constitute a diagnostic tool and a guideline for therapy during follow-up. Originally identified by Davies et al. in 1982 in 8 patients who had necrotizing glomerulonephritis but no immune deposits or systemic vasculitis (1), ANCA are now regarded as a serological marker for active pauci-immune necrotizing and crescentic glomerulonephritis, either in their renal-limited form or associated with systemic vasculitis such as Wegener's granulomatosis (WG), microscopic polyangütis (mPA), and Churg-Strauss syndrome (CSS) (2-9). The usefulness of ANCA detection for the diagnosis of these forms of vasculitis is now established but its usefulness on follow-up remains disputed (10-13). Two major ANCA antigens have already been identified. Proteinase 3 (PR3) in a serine protease of 29 kDa initially identified by Kao and producing a cytoplasmic staining pattern termed cANCA by indirect immunofluorescence (IIF) (14,15). Myeloperoxidase (MPO) is another myeloid lysosomal enzyme producing an artefactual perinuclear staining of ethanol-fixed neutrophils termed pANCA (2,16). Both are localized in the azurophilic granules of neutrophils and monocytes, are translocated to the cell surface during cell activation (17), and are able to interact directly with ANCA. Despite this common location, MPO and PR3 are associated with a broad spectrum of clinical conditions.

ISSN:0886-022X    

DOI:10.3109/08860229609047708

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor