摘要:

Diet can influence the changes in plasma lipoprotein concentrations that occur with exercise. Dietary factors alone, however, probably do not account for the lipoprotein profiles of physically active people. Whether exercise or diet exerts the dominant effect on lipids and lipoproteins depends largely on the level of exercise achieved and the total energy balance. More well designed research is required to examine the effect of diet on lipids and lipoproteins in people of different levels of physical fitness taking part in a variety of physical activities.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Current approaches to achieving dietary change are reviewed. The more successful strategies are those that are tailored to the individual and his or her situation and readiness for change, supported when possible by broader social and environmental changes. Some methods of reducing dietary fat intake are better accepted and maintained than others; an emphasis on these may be helpful.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

The recently revised guidelines for cholesterol management in Europe and the USA have focused attention on triglycerides and HDL cholesterol as risk factors for coronary heart disease. In the present review, I shall discuss therapeutic considerations in the treatment of patients with hypertriglyceridemia or low HDL cholesterol in the context of these new recommendations. I shall also consider recent studies in which the effect of triglyceride-lowering drugs on the concentrations and metabolism of lipoproteins in patients with dyslipidemia are evaluated.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

At least 20 million postmenopausal women worldwide now use some form of hormone replacement therapy. This figure is increasing because the resistance of the medical community to these therapies is diminishing and because of increasing acknowledgement of the benefits of such therapies on the cardiovascular system. This is a remarkable development for a medication originally used to relieve menopausal symptoms such as hot flushes and to prevent bone loss. Although several mechanisms are now accepted to be involved in this protection from cardiovascular disease, changes in plasma lipoproteins remain a major area of research interest. The main issue in this field, whether the addition of a progestogen to postmenopausal oestrogen ('combined therapy') will diminish the benefits on the cardiovascular system, remains unresolved, but combined therapies have now been formulated that minimize the potentially detrimental effects of progestogens on plasma lipoproteins. Recent findings of interest include the effects of these therapies on plasma lipoprotein (a) concentration and on LDL particle size. Studies of the mechanisms behind such changes are needed.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Beta-hydroxy-β-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (HMG CoA RIs) are now being prescribed in many different countries, and the number of patients treated with these compounds is estimated to be over 1.5 million. The spectrum of indications for these drugs is enlarging. Thus, not only patients with primary hypercholesterolemia are suitable candidates for therapy with HMG CoA RIs, but also patients with other forms of familial and non-familial (secondary) dyslipidemias. The safety and tolerance profile is remarkably good and adverse effects tend to be mild and rare. Currently, several primary and secondary intervention trials are ongoing or in preparation to investigate the influence of HMG CoA RIs on cardiovascular morbidity and mortality.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

LDL-apheresis is an extracorporeal plasma-perfusion method that selectively removes apolipoprotein B-containing lipoproteins from the blood. It is indicated for patients with homozygous and drug-resistant heterozygous familial hypercholesterolemia. Clinical and angiographic regression of coronary artery disease has been demonstrated in patients treated with cholesterol-lowering programs that include LDL-apheresis.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID