摘要:

In animal studies antioxidants have demonstrated antiatherosclerotic actions, but hitherto not in human studies. Prospective epidemiological data suggest that high doses of vitamin E have beneficial effects on major coronary heart disease. Unresolved questions concerning the role of LDL oxidation and antioxidants in atherosclerosis are discussed. It remains to be shown if antioxidants can retard lesion progression in humans, and by what mechanisms they are acting.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Lipoprotein (a) is a major inherited risk factor for vascular diseases, including coronary atherosclerosis, restenosis, and stroke. The pathologic mechanisms are uncertain, but are likely to involve the unique plasminogen-like component of this lipoprotein, apolipoprotein (a). Studies suggest that apolipoprotein (a) can enhance lipid deposition in vessel walls, interfere with fibrinolysis, modulate smooth muscle cell activity, and induce endothelial dysfunction. This review discusses the key concepts relating to these mechanisms, with emphasis on recent studies.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Insulin resistance, which is a prevalent condition, has been associated with a cluster of metabolic disturbances that increase the risk of non-insulindependent diabetes mellitus and cardiovascular diseases. In this review article, the complexity of the etiology of insulin resistance is emphasized as it results from the interaction of genetic and environmental factors. Potential cellular defects underlying insulin resistance are discussed as well as the relation of impaired insulin action to dyslipidaemia and coronary heart disease.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Antithrombotic therapy has assumed a central role in the therapy of the acute coronary syndromes and chronic coronary artery disease. The theoretical rationale for antithrombotic therapy, and the established and evolving roles of antiplatelet agents and anticoagulants in coronary disease are reviewed. Emphasis is focused on new antithrombotic agents and novel combinations of existing agents.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

The discovery of polypeptide mitogens capable of stimulating angiogenesis has inspired research addressing the potential of these agents in the treatment of ischaemic syndromes. Ischaemia or necrosis with associated inflammation has been found to increase the production of growth factors and receptor response. Administration of various exogenous angiogenic agents by several routes has resulted in enhanced growth of collateral vessels in animal models of myocardial, peripheral arterial, and cerebral insufficiency. Therapeutic angiogenesis may have an immense clinical potential.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID