ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Emerging evidence suggests that subclasses of LDL, characterized by variations in density, size, and chemical composition of LDL particles, are of important clinical significance. Accumulating case-control studies demonstrate that a predominance of small, dense LDL particles (LDL subclass phenotype B) is associated with an increased risk of coronary heart llisease, and several potential atherogenic mechanisms have been proposed. New studies also demonstrate that LDL subclass phenotype B is an integral feature of the insulin resistance syndrome. In addition to the well-documented genetic influences on LDL subclass distributions, lipid-altering drugs, diet, and exercise all appear to affect LDL subclasses. A better understanding of this combination of genetic and environmental influences coold lead to the development of effective intervention strategies for the prevention of coronary heart disease.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Low HDL cholesterol is an important predictor of cardiovascular risk. Considerable effort has been undertaken to improve the predictive value of HDL cholesterol by the quantification of HDL subclasses. Controversy still exists as to whether quantification of apolipoprotein A-l, selective precipitation of HDL2, or differential immunoassays of apolipoprotein A-l-containing particles improve the diagnostic value of HDL cholesterol. Some quantitatively minor subclasses of HDL, namely pre-β-1-lipoprotein(AI) and γ-lipoproteinE, contribute significantly to the release of cellular cholesterol into the plasma compartment, and possibly to the antiatherogenic role of HDL. These particles can only be separated from the bulk of HDL by laborious electrophoretic techniques that, although provide important insights into the physiology of reverse cholesterol transport, are not suitable for clinical laboratories. Thus, to date, clinicians are not recommended to extend the measurement of HDL cholesterol to include the determination of HDL subclasses.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

Despite an exponential increase in the number of published papers reporting the clinical significance of lipoprotein(a), it is very difficult to relate the lipoprotein(a) data obtained from different studies because of wide dissimilarities in the reported values. Methodological aspects such as differences in assay design, degree of optimization, antibody source, calibration, and the expression of lipoprotein(a) values are the main contributors to the observed lack of comparability. A major effort in the evaluation and standardization of lipoprotein(a) assays is required to fully evaluate the clinical potential of lipoprotein(a) measurements.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID

摘要:

The oxidation of LDL is now commonly implicated as an initiator of atherosclerosis and a standard in-vitro LDL ‘oxidizability’ test is required. This review will discuss current problems and advances that have been made in our understanding of the molecular mechanisms of radical-mediated LDL oxidation and antioxidation, how they relate to the in-vitro assessment of the ‘oxidizability’ of LDL and how they may be relevant to in-vivo LDL oxidation. Tocopherol-mediated peroxidation is used as a novel model of LDL lipid oxidation to discuss why terms such as ‘lag time’ are features of the in-vitro oxidation conditions, rather than being inherent to LDL oxidation per se. In addition, we will also cover why it is premature, at present, to use one particular LDL oxidizability test as a standard.

ISSN:0957-9672    

出版商:OVID    

年代:1994

数据来源: OVID