ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

Postprandial lipoprotein metabolism has been evaluated by measuring triglyceride concentrations in whole plasma and in lipoprotein fractions after an oral fat load. This approach has yielded important insights into the relation of triglyceride metabolism to lipoprotein lipase, to other lipoproteins, particularly HDL, and, most importantly, to coronary heart disease. Biosynthetic labelling of intestinal lipoproteins with vitamin A esters allows tracing of the non-degradable cholesteryl ester portion of chylomicrons and their remnants. A limitation of the method is that vitamin A is subject to neutral lipid transfer. Quantification of apolipoprotein B48, the structural protein of chylomicrons, has the potential of directly following the metabolic fate of chylomicron particles in plasma.

ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

The components of metabolic syndrome are insulin resistance, hyperinsulinism, central obesity, dyslipidemia, hypertension, and impaired glucose tolerance or non-insulin-dependent diabetes mellitus. There is extensive overlap of different abnormalities between each disorder of the metabolic syndrome. Consequently, diagnosis of the metabolic syndrome requires screening for each abnormality if one component has been verified. The crucial issue is that individual componentsper seare risk factors for coronary heart disease and consequently their clustering in the metabolic syndrome aggravates the risk of coronary heart disease.

ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

The purification, characterization and cloning of several proteins involved in cellular uptake, lysosomal degradation, intracellular trafficking, and metabolism of sterols and lipids has permitted a rapid expansion in our understanding of the metabolic basis of inherited disorders of cellular lipid metabolism. The discovery of several allelic variants of lysomal acid sphingomyelinase and lysosomal acid lipase has not only provided insights into genotype-phenotype relationships in Niemann-Pick disease, Wolman disease and cholesteryl ester storage disease but will also contribute to simple future molecular diagnosis of these disorders.

ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

A growing number of DNA sequence alterations has been shown or proposed to contribute to the formation of atherosclerotic vascular disease or its intermediate phenotypes. Methods used in their determination are briefly reviewed.

ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

The analysis of cellular markers for the assessment of cardiovascular risk is a new concept emerging from research on the cell biology of atherosclerosis. The most promising aspects relate to the investigation of abnormal activation and differentiation of cells involved in the atherosclerotic process isolated from peripheral blood, for example, monocytes and platelets. In addition, several plasma proteins have been identified as markers for cellular processes or immunologic activation. These are potential candidates for an improved identification of individuals at increased risk. The lack of specificity and sensitivity of the currently available parameters for individual risk assessment require further search for more specific risk markers. Furthermore, it will be necessary to develop strategies to reliably monitor therapeutic interventions. This review will focus on potential future directions to establish cellular markers for these purposes.

ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

The past decade has seen the completion of a series of prospective epidemiologic studies evaluating the association between haemostatic factors and cardiovascular diseases. All the studies agree that fibrinogen is a strong, independent cardiovascular risk factor. Various cross-sectional studies have revealed numerous interactions between fibrinogen and other risk factors. However, our understanding of these interrelations is still incomplete. A broad pathophysiologic basis and the results from clinical studies further argue for a crucial role of fibrinogen in atherothrombogenesis.

ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

Hypofibrinolysis, leading to the decreased removal of fibrin deposits and the breakdown of extracellular matrix, is a candidate for a role in the development of atherothrombosis. Reduced plasma fibrinolysis is mainly attributed to an increased plasminogen activator inhibitor (PAI)-1 level, which is considered to be a biological risk factor for coronary heart disease. Increased plasma PAI-1 levels are related to the insulin resistance syndrome and could partly explain the role of this metabolic syndrome in the development of atherothrombosis. Increased PAI-1 expression has been described in atherosclerotic lesions. Lipoprotein (a) [Lp(a)] also accumulates in the damaged vessel wall. The atherogenic effect of Lp(a) could partly be explained by its interaction with the fibrinolytic system through apolipoprotein (a), which presents a strong homology with plasminogen. Contributions of systemic and local disturbances of PAI-1 and Lp(a) expression in atherothrombosis have been reported.

ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID

摘要:

Lipoprotein(a) [Lp(a)] is thought to be atherogenic in part because of the similarity of its apolipoprotein (apo) (a) component to plasminogen. Although considerable datain vitrosuggest that Lp(a) could be thrombogenic by competitively inhibiting plasminogen activation, not all reports agree. To date, no human studies strongly support this hypothesis. Individual variations in the apo (a) sequence may affect its ability to bind fibrin and may account for some of the variable results. In addition, other pathologic activities of Lp(a) have recently been suggested.

ISSN:0957-9672    

出版商:OVID    

年代:1993

数据来源: OVID