ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecular level. Studies carried out in a variety of heterologous expression systems, as well as the use of microsomal triglyceride transfer protein inhibitors in hepatoma cell lines, have been critical to this progress. It has been shown that microsomal triglyceride transfer protein plays a key role in the early stages of lipoprotein assembly, most likely by transferring lipid to nascent apolipoprotein B as it enters the lumen of the endoplasmic reticulum. The evidence indicates that microsomal triglyceride transfer protein does not play a major role in addition of bulk core lipid in the late stages of apolipoprotein B48lipoprotein assembly. Thus, microsomal triglyceride transfer protein appears to control the number of apolipoprotein B lipoprotein particles secreted but not the lipid composition.

ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Important advances in our understanding of the regulation of hepatic apolipoprotein B secretion have been made in the past year. A diverse group of studies have provided evidence that the inhibition of cholesterol synthesis by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors decreases the hepatic assembly and secretion of apolipoprotein B-containing lipoproteins. Apolipoprotein B kinetic studies performed in animals and human individuals indicate that inhibition of VLDL-apolipoprotein B secretion is an important mechanism whereby reductase inhibitors decrease plasma concentrations of these lipoproteins. Studies in cultured hepatocytes and in-vivo animal models have provided insights into how reduction of cholesterol synthesis decreases apolipoprotein B secretion. A decrease in hepatic acyl-coenzyme A: cholesterol acyltransferase activity, secondary to reduced microsomal cholesterol concentrations, has been implicated.

ISSN:0957-9672    

出版商:OVID    

年代:1997

数据来源: OVID