摘要:

AbstractCytogenetic analysis of a metastatic biphasic synovial sarcoma showed two structural abnormalities: t(X;7)(q 11 or 12;q32) and t(7;14)(q22;q11.2). This is the first report of a synovial sarcoma without the involvement of either Xp11 or 18q11.

ISSN:1045-2257    

DOI:10.1002/gcc.2870030112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1991

数据来源: WILEY

摘要:

AbstractThe recurring chromosomal 9;II translocation [t(9; II) (p22;q23)] typically is associated with acute monoblastic leukemia, but a number of patients with acute lymphoblastic leukemia also have been reported to have the t(9; II). To investigate the cell lineage in the latter cases, we analyzed DNA from the leukemic cells of an 8‐year‐old girl with acute lymphoblastic leukemia and a t(9;I I) for rearrangements of the immunoglobulin and T‐cell receptor genes. Rearrangements of both immunoglobulin heavy‐chain loci and of one lambda light‐chain gene were detected, as well as deletions affecting both alleles of the kappa light‐chain genes; T‐cell receptor genes were in germline configuration. These results provide further evidence that the 9; I I translocation is not limited to myeloid lineage leukemia and may be observed in acute lymphobla

ISSN:1045-2257    

DOI:10.1002/gcc.2870030113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1991

数据来源: WILEY

ISSN:1045-2257    

DOI:10.1002/gcc.2870030101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1991

数据来源: WILEY