摘要:

Abstract:The nucleus accumbens is an important telencephalic region, which is the target limbic and mesolimbic pathways. Because of an ongoing physiological study of the effects of dopamine, we wanted to determine regional differences of dopamine and norepinephrine concentrations in the nucleus. As determined by radioenzymatic assays, dopamine levels were not significantly different in the anterior‐posterior dimension, averaging approximately 187 ng dopamine/mg protein. Substantial amounts of norepinephrine were found throughout the nucleus, but the levels were significantly higher in the caudal portions of the nucleus, being approximately 4.5 times higher than in the anterior portion

ISSN:0022-3042    

DOI:10.1111/j.1471-4159.1983.tb12685.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:[2,3‐3H]4‐Aminobutyraldehyde ([3H]ABAL) was injected subcutaneously into mice, which were sacrificed at various intervals following injection. [3H]γ‐Aminobutyric acid ([3H]GABA) synthesizedin vivofrom [3H]ABAL was extracted from the brains, separated, and quantitated. The results showed that in the brain, injected [3H]ABAL was rapidly transformed into [3H]GABA. [3H]ABAL may penetrate the blood‐brain barrier into the central nervous system and then be oxidized to

ISSN:0022-3042    

DOI:10.1111/j.1471-4159.1983.tb12686.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0022-3042    

DOI:10.1111/j.1471-4159.1983.tb12687.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0022-3042    

DOI:10.1111/j.1471-4159.1983.tb12688.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY