摘要:

Recent experimental and clinical evidence has pointed to the decreased ability of burn polymorphonuclear leukocyte (PMN) cells linked with serum-borne burn injury-related factors to develop phagocytosis connected metabolic reaction (oxygen burst). In this study, burn patients' PMNs showed an impaired rate of oxygen consumption during phagocytosis of opsonified zymosan, which correlated inversely with the degree of complement activation (measured as the ratio of C3d to native C3). Mimicking the burn condition (complement consumption), healthy donors' PMN cells' oxygen consumption rates were measured in the presence of normal and complement activated normal serum (CoVF-, zymosan-, HAIgG-treated serum). Basal levels (resting state) of PMN oxygen consumption were higher, and oxygen uptake of stimulated cells was lower (dose dependence) in the presence of complement activation products. C3a or C3d removal (but not C3c) from burned or complement- activated normal serum resulted in an increase in burn and normal PMN oxygen consumption but not to normal levels. C3a and C3d protein fractions also inhibited PMN oxygen uptake upon stimulation. Results of this study suggest that PMNs subjected to complement activation products show a depressed ability to develop oxygen burst upon stimulation, which may contribute to neutrophil dysfunction in burns. Part of the observed alteration may be due to the presence of C3 split productsPossible mechanisms hypothesized to play a role in the development of C3 split products-related PMN alterations in burns are discussed on the basis of obtained results and data from relevant literature.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

A 38-year-old man contacted a 220-volt power source and sustained fractures of C-2, C-5, T-7, and T-11 from the resultant tetanic muscle contractions. Although he complained of neck pain, he had no neurologic deficit. Multiple fractures of the spine were seen on spinal films and CT scanning. The patient was successfully treated by external stabilization in a halo-body cast for 12 weeks. Multiple spine fracture after electric injury is extremely rare, but use of such improved diagnostic methods as CT scanning will detect more cases of this nature in the future.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Vancomycin dosage requirements were studied in six young burn patients, in whom initial doses ordered by house officers were monitored using peak and trough vancomycin serum concentration measurements. Dosage regimens were adjusted to produce peak and trough levels within the recommended range of 30 to 40 mg/L and 5 to 10 mg/L, respectively. Vancomycin dosages and serum levels were compared initially and after dosage adjustment, and with the manufacturer's recommended doses, the data suggested that current manufacturer's recommendations are too conservative for optimal dosage of vancomycin in young burn patients. We suggest dosage regimens of 60 mg/kg/day in divided doses in this patient population, dosing intervals to be determined by peak and trough vancomycin serum concentration measurement.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

During a three-year period, 28% of the scald burns in adults admitted to the University of Miami/Jackson Memorial Burn Center were associated with overheated radiators. This group constituted 10.4% of all adult admissions to the burn service. The characteristic physical pattern of injury averaged 9% of the body surface area. The length of hospitalization averaged 10 days.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

The objectives of this retrospective study of 110 burn patients from the University of Florida Burn Intensive Care Unit (BICU) and 8,463 patients from the National Burn Information Exchange (NBIE) were to determine if a difference existed between patients with anterior and/or posterior torso burns from the standpoint of hospital stay and mortality. Anterior torso burn patients stayed in the BICU about 30 days, posterior torso patients 20 days. The reverse was found in the NBIE study, posterior torso burn patients staying 39.4 days and anterior torso burn patients staying 21.6 days. Among NBIE cases, mortality was the same for both anterior and posterior torso burns, patients with fullthickness burns having a 50% survival with 50% involvement, but those with partial-thickness burns having an 80% survival with 50% involvement. Age and total body surface area (BSA) involvement proved more significant predictors of hospital stay and mortality than the location of torso burns: anterior or posterior. Problems inherent in treatment of circumferential burns of the torso are also discussed.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

The use of alternating silver sulfadiazine and silver sulfadiazine-nitrofurazone, sequentially compared in 112 patients in a prospective study, proved an effective combination for treatment of major burns. The clinically undesirable side effects resulting from using either agent alone were eliminated or significantly diminished without altering the pattern of microbial isolates from the burn wound and without promoting the development of more resistant strains of Staphylococcus aureus.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

A review of the burn literature revealed no systematic investigation of the specific effects on wives when their husbands are severely burned. The behaviors and psychological and emotional responses of 25 burn patients' wives from admission to discharge were therefore studied at a regional burn center. Psychological support services were also offered to these women and the patients. Psychosocial histories of the 25 wives were obtained, and they were observed and interviewed clinically at least twice by a liaison psychiatric nurse, the liaison psychiatrist providing evaluative consultation. The grief reactions and major challenges experienced by the wives during the three phases of resuscitation, acute burn care, and rehabilitation are discussed.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

FRST, a topical ointment used in the Pacific Northwest for treatment of burn wounds, was assessed for its effect on burn wound contracture and healing in the rat scald burn model and compared with treatment of burn wounds by silver sulfadiazine or saline. Male rats received scald burns to two identical rectangular areas on the back, each equidistant from the dorsal midline. One burn wound on each animal received treatment with either FRST, silver sulfadiazine, or saline. The opposite side acted as an untreated controlIn this model, we were unable to demonstrate that any of these agents altered wound contraction rates. However, FRST significantly prolonged the length of time required for healing compared to that in silver sulfadiazine- and saline-treated wounds and to untreated control burn wounds.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID