摘要:

SummaryThe role of the bovine major histocompatibility complex in bovine leukaemia virus (BLV) infection and disease progression was investigated in a herd of Shorthorn cattle (n= 117). The frequency of cows that were seropositive to BLV‐glycoprotein antigen was 51%. Twenty‐three per cent of the seropositive cows were lymphocytotic. At the herd level, relative resistance to BLV‐dependent B‐cell proliferation and lymphocytosis among seropositive cows was associated with bovine lymphocyte antigen (BoLA)‐DA7, whereas susceptibility was associated with BoLA‐DA12·3. These associations were also confirmed at the family level, where BoLA phenotypes were used as haplotypic markers. Among the offspring of one BoLA‐heterozygous sire (n= 33), resistance segregated with the DA7 haplotype and susceptibility with the DA12·3 haplotype. In this sire group, maternal transmission of the BoLA‐w8 allele was associated with increased susceptibility to B‐cell proliferation and lymphocytosis in w8/DA12·3 heterozygotes. These data provide the first evidence that subclinical progression of BLV infection is under the control of the BoLA complex, and suggest that the BoLA system can be used to select for resistance to B‐cell proliferation and the development of lymphocytosis

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03191.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SummaryPlasma or serum samples from 12 Arabian and 181 standardbred horses have been typed using an immunofixation technique to determine electrophoretic polymorphism of equine third complement component (C3). Six distinctly different electrophoretic patterns of equine C3 have been recognized thus far. SDS PAGE analysis of equine C3/anti C3 complexes revealed that the submolecular structure comprised an alpha chain and beta chain of molecular weights approximately 118000 and 63000 daltons respectively. The molecular weights of the alpha and beta chains were similar in all electrophoretic variants tested.Family data derived from 73 mares, 21 stallions and 99 offspring suggested that the six electrophoretic phenotypes were inherited by means of three codominant alleles named C3–1, C3–2 and C3–3 at a single autosomal

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03192.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SummaryPreliminary evidence for the fifth autosomal linkage group in the horse, comprised of the loci for a red cell alloantigen (U) and serum protease inhibitor (Pi), was demonstrated by means of paternal half‐sib groups in thoroughbred, standard‐bred and Arabian breeds. Recombination frequency in males was estimated to be 0–125 ±

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03193.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SummaryLinkage between the genes coding for immunoglobulin heavy‐chain allotypes and some serum α‐protease inhibitors was demonstrated in pigs by means of segregation data in families. A recombination frequency of about 8% was estimated. This represents evolutionary conservation of an autosomal linkage group as linkage between the homologous loci has previously been reported, in humans and in

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03194.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SummaryThe distribution of biochemical genetic variants was examined among eight inbred strains of mice, which served as contributors to a heterogeneous stock of mice (HS), and in short‐sleep (SS) and long‐sleep (LS) mice, selectively bred from the HS stock for differential ethanol sensitivity. Fifteen loci for enzymes of alcohol and aldehyde metabolism, as well as 12 other biochemical loci, were investigated. Thirteen of these loci exhibited allelic variation between strains, of which six were separately fixed in the SS and LS mice. Comparisons of genetic similarity coefficients, based upon the distributions of allelic variants for the loci examined, with behavioural sensitivities (sleep‐time) to an acute dose of ethanol for the inbred and selected strains of mice, indicated no correlations between these data. This suggests that this collective group of loci are not useful indicators of the genes selectively bred in the SS and LS strains, which are responsible for the differential sensitivities to acute doses of et

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03195.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SummaryHorse DNA samples digested withPstIand probed with the rabbit β1globin gene show three phenotypes determined by one fragment of variable length (about 5·1 or 3·3 kb). Family data demonstrate that these fragments segregate as Mendelian alleles. The frequencies of the two alleles are 0·66 for the 3·3‐kb fragment and 0·34 for the 5·1‐kb one. Another polymorphism has been detected withBamHI.Again three phenotypes determined by two alleles (fragments of 7·5 and 3·8 kb) have been observed. Allelic frequencies of the 7·5‐ and 3·8‐kb fragments are 0·24 and 0·76 respectively. The two polymorphic sites are non

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03196.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SummaryEleven flocks of three Spanish sheep breeds have been studied: four Churra, four Lacha and three Manchega. Genetic variations between flocks of the same and different breeds have been analysed, using eight genetic blood systems and a wide range of statistical methods. The results show that the Churra, Lacha and Manchega breeds present significant differences between each other. Significant intraracial variations have been observed in Churras and Lachas, although they were almost non‐existent in Manchegas. In some cases the genetic distances between flocks of the same breed were greater than the distances between flocks of different breeds. The data indicate that the closest breeds genetically are Lacha and Mancheg

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03197.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SummaryBirth weights of 708 live piglets and weaning weights of 566 piglets were used to investigate the effect of the swine lymphocyte antigen (SLA) complex on these traits in Large White pigs. Piglets were from litters of a long‐term selection experiment to measure response for selection to increase litter size. SLA haplotypes were determined using conventional class I antisera. A total of 14 haplotypes were detected. The effect of SLA haplotype on birth and weaning weights was investigated using a statistical model that included the effects of experimental group, sire, dam, sex and SLA haplotype. Results indicated that SLA class I haplotype 13.1.3 increased birth weights (P<0·10) and significantly increased weaning weights (P<0·01). This effect of haplotype 13.1.3 on weaning weight was 605 ± 215 g (0·3 standard deviations). SLA class I homozygosity did not appear to affect birth and weaning weights. These results suggest that the SLA complex plays an important role in early growth in the pig and that further study of SLA effects on growth and reproduction are warr

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03198.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SummaryThree additional pretransferrin types have been identified by one‐dimensional PAGE technique in New Zealand White and Californian rabbits. The six alleles are designatedPrtA,PrtB,PrtC,PrtD,PrtEandPrt.FIt is likely that three of these six alleles are identical to those reported previousl

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03199.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SummaryThe possibility of linkage between the recessive gene controlling the rectovaginal constriction (RVC) syndrome in Jersey cattle and 13 loci controlling blood groups and polymorphic proteins was studied. No evidence of close to moderate linkage was found between the RVC locus and any of the systems A, B, C, F, L, S, Z, R′, Hb, Tf, Am‐1 and Ca. No definite conclusion was possible with the M sys

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1986.tb03200.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY