摘要:

The occurrence of brain damage in 57 full term neonates was investigated. The infants were submitted to a prospective protocol involving clinical (neurological and electroencephalographical) and biological examinations, including the determination of the fibrin‐fibrinogen degradation products in the blood and cerebrospinal fluid on D1, D3, D8 and D15. Psychomotor events were followed up for a year. Traumatic lumbar taps did not disturb the results significantly. Blood samples were not found to contain noticeable amounts of FDP. Conversely, the existence of FDP in CSF was not infrequent near to delivery and was shown to be closely related to brain damage as evaluated by the psychomotor event

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb04390.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Unilateral cerebral microembolism was performed in the rat by injecting calibrated, 50 μm in diameter, carbonized microspheres into the internal carotid artery. The events that follow brain ischemia due to cerebral embolization were studied by the analysis of the blood‐brain barrier (BBB) function, the degree of regional cerebral blood flow (CBF) and the development of brain edema.Two hours after embolization there was no change in the brain water content. The local CBF (14C‐ethanol technique) was only reduced in the ipsilateral hemisphere. Twenty‐four hours after embolization the brain water content was increased significantly in the ipsilateral, but not in the contralateral hemisphere. Local CBF further decreased in the ipsilateral hemisphere and a reduction in flow was also observed in the contralateral hemisphere. Embolization led to an increase in the BBB permeability, analysed as regional penetrability of3H‐dextran and of Evans blue‐albumin complexes, which was restricted to the side of the injection of the mi

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb04391.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The possibility of disturbed dopamine and serotonin metabolism in senile dementia of Alzheimer type was studied. The basal concentrations of homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA) in cerebrospinal fluid (CSF) were studied in 28 patients with senile dementia of Alzheimer type and in 13 controls of similar age with no neurological disease. The concentrations of HVA were significantly reduced in the dementia patients compared to the concentrations of the controls. The values of HVA were also significantly reduced in the most severely demented patients compared to the less severely demented ones. There was a slight but statistically significant decrease in the 5‐HIAA levels in the dementia patients compared to the levels of the controls. The 5‐HIAA levels were reduced in the most severely demented patients compared to the controls but not when compared with the less severely demented patients.It is concluded that in severe forms of senile dementia of Alzheimer type, there is a decrease in the levels of HVA and 5‐HIAA in CSF which may reflect a decreased turnover of dopamine and serotonin. Patients diagnosed as senile dementia of Alzheimer type, but with less severe symptoms, had levels of HVA and 5‐HIAA similar

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb04392.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A protein that detaches ribosomes from rough microsomal membranes (“detachment factor”) (DF) was isolated from the cytosol fraction of rat and human muscle. The procedure of isolation included differential centrifugation, precipitation with ammonium sulfate and column chromatography with Sephadex G‐100. The protein which is not completely homogenous, has a molecular weight of 50,000–60,000 daltons, is heat labile and has an optimum pH at 7.4–7.6. The DF activity of the protein is inhibited by soybean trypsin inhibitor (73%), pepstatin (67%), and leupeptin (42%), although no proteolysis could be measured. The DF activity was tested on muscle samples (rough microsomal membranes) obtained from Duchenne muscular dystrophy (DMD) patients (7 cases) and normal controls (16 cases). The yield of membrane bound ribosomes (MBR) obtained from muscle samples of DMD patients by extraction with DF is 5‐fold higher than from muscle samples of normal controls. The difference in MBR yield is not related to the type of DF. Similar values for MBR were obtained with rat and human (normal and dystrophic) DF. Ribosomal protein synthesis (RPS) with ribosomes extracted by DF showed values similar to the RPS of detergent extracted ribosomes. Our findings suggest the observed increase in membrane bound ribosomes in DMD probably results from increased levels of mRNAs coding for membrane and secretory proteins such

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb04393.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The occurrence of anticonvulsant osteomalacia was studied in 31 epileptic inpatients, 16 women and 15 men.Disturbances in biochemical parameters indicating osteomalacia were frequent. Thirty two per cent of the patients were hypocalcemic, 55% had an increase in S‐ALP and 26% in U‐HOP, and dU‐Ca was decreased in 55%. The S‐25OHD3concentrations were significantly lower in the patients compared with healthy controls. BMD was decreased in females but not in males compared with the controls. Histomorphometric analysis revealed an increase in the amount of osteoid, but the amount of trabecular bone was no lower than in the controls. The amount of resorption surfases was increased in the females, but not in the males. The patients who took less physical activity had a pronounced decrease in BMD.The conclusion drawn was that osteomalacia is a frequent complication of long‐term anticonvulsant medication, especially among institutionalized

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb04394.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Eleven patients with long‐standing progressive myoclonus epilepsy, PME, and age‐ and sex‐matched epileptic controls received L‐tryptophan (L‐Trp) 100 mg/kg body weight combined with carbidopa in addition to their usual anticonvulsant regimen. During six weeks of the trial an improvement in activities of daily living and a decrease of action myoclonus was noted in the PME patients. The frequency of seizures compared with the past year decreased significantly in the PME patients, but not in the epileptic controls. Changes in the EEGs of the PME patients were scant, but a slight decrease was noted in myoclonic spikes. Both plasma Trp and platelet 5‐HT increased significantly and at least as much as in epileptic controls. 5‐HIAA and HVA concentrations in the CSF of the PME patients increased significantly during the trial. The results support previous findings concerning Trp treatment in PME, and longer trials with Trp + carbidopa could be of value in

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb04395.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Persistent pain: Modern methods of treatment. Ed. by Sampson LiptonTraugott Riechert: Stereotactic brain operations, methods, clinical aspects, indicationsJohn L. Andreassi: PsychophysiologyNeurotraumatologie. Derzeitige Schwerpunkte. Ed. by H. H. WieckB. M. Kulig, H. Meinardi&G. Stores (eds.): Epilepsy and behavior ‘79. Swets&Zeitlinger, Lisse, 1980A. Arendt: Taschenbuch der klinischen NeuropathologieD. Bindra: The brain's mindMonoamine oxidase inhibitors. The state of the art. Ed. by M. Youdim&E. PaykelR. S. Maurice‐Williams: Spinal degenerative diseaseThe borderland of epilepsy. A reappraisal. Ed. by M. Dam&J. Gordon

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb04396.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY