摘要:

ABSTRACTSingle injections of ENU to WAG‐rats were given in the perinatal period and repeated injections of MNU to adult WAG‐rats. In the tables illustrating the various experiments, the occurrence of tumors is given for each animal; the tumors are classified according to their sites. For the brain tumors a subdivision is made between those macroscopically visible and those discovered only under microscopy. It is noteworthy that the ratio between neural and extraneural tumors in the perinatally exposed animals is rather constant (about 90 and 10 per cent, respectively). In the experiments on young adult rats neural tumors still predominate, but extraneural ones rise to about 40 per cent. The incidence of neural tumors is impressively high in perinatal induction experiments (>95 percent). Almost all CNS tumors showed the characteristics of oligodendrogliomas; highly differentiated in the smaller tumors and more anaplastic with regressive changes in the larger o

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1977.tb05630.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe cytotoxic action of various single doses of MNU and ENU on developing neural and extraneural tissues was studied at different stages of development. Examination revealed lethal damage (L.I.) and mitotic inhibition (M.I.), confined to proliferating cells only, and caused by the number of alkyl groups administered. In studying the duration of M.I. a difference was found in duration of the cell cycle arrest after MNU or ENU. The arrest lasted longer for MNU than for ENU, and the neural tissues turned out to be more sensitive than the extraneural ones. Moreover, among the reappearing mitotic figures abnormal ones were noticed frequently. After pulse‐labeling with thymidine this arrest could be traced to take place in or before entering the S‐phase. During the period of this arrest a low, but specific, activity was found that might point to the existence of repair‐processes in vivo. Finally, we directly demonstrated alkylations in tissue‐sections by the use of (14C‐methyl)‐MNU. High radioactivity was found with a random distribution over the various tissues, cell types and even cellular compartments. Therefore‐in contrast with the cytotoxic effects‐alkylation seems to occur in all cell types. In conclusion, it seems justified to consider the matrices of proliferating cells in the central nervous system as the target tissue‐areas for the carcinogenic action of both MNU and ENU. Re‐entrance of these damaged cells into their cycle prior to the elimination of altered bases from DNA might be of great importance for the pro

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1977.tb05631.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe report provides prognostic information on 60 patients (aged 16 to 40 years) with ischemic stroke. Immediate mortality from stroke is low and long‐term mortality is due to other causes than cerehrovascular disease. The recovery from neurological deficits is good except for patients with occlusions of the internal carotic artery or the proximal part of the middle cerebral artery. Reinfarction is rare (about 0.5 per cent annually) and other late neurological complications do not seriously affect long‐term prognosis. More than 80 per cent of the patients will be able to resume work on a full or part‐time

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1977.tb05632.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe dose‐effect relationship of intracarotid administered aminophylline on cerebral hemodynamics in man was investigated by means of an intraarterial133Xenon injection method. A dose dependent vasoconstriction was clearly demonstrated. The maximum efficacy expressed as mcasured decreased in global cerebral blood flow was 21.9 per cent ± 6.2 SD. Administration of as little as 1 mg aminophylline produced a measureable vasoconstricti

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1977.tb05633.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe purpose of this study was to measure the changes in potassium concentration in human cisternal Cerebrospinal fluid following successful resuscitation after cardiac arrest. We also wished to examine whether or not changes in potassium concentration in the cisternal cerebrospinal fluid could be correlated to the ability to regain normal cerebral function. 41 patients were studied, of whom 20 regained consciousness and 21 did not. In those who did not regain consciousness there mas a significant increase in the potassium concentration found in samples obtained between 40 and 50 min, and between 50 and 60 min after cardiac arrest. The potassium Concentration decreased to normal values during the following hours. Lumbar spinal fluid did not reflect the changes in cisternal fluid. The results suggest that the potassium concentration of cisternal cerebrospinal fluid, obtained soon after cardiac arrest, might give an indication of the degree of cerebral damage caused by cardiac arrest.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1977.tb05634.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTSixty‐four young adults (aged 16 to 40 years) with ischemic stroke were analyzed in retrospect with regard to possible pathogenetic mechanisms. In older patients various predisposing factors emerge (arterial hypertension, hyperlipidemia etc.) which are rare among younger age groups. In patients lacking predisposing causes the stroke incidence exhibits a seasonal variation. It is suggested that infection may be important for the development of ischemic strok

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1977.tb05635.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTIncreased concentration of CSF homocarnosine has recently been found in a family with spastic paraplegia. CSF homocarnosine was therefore determined in 13 patients from other families with familial spastic paraplegia. Also examined were seven patients from families where the constellation of symptoms and signs was more complex, but also comprised spastic paraplegia, and five patients with non‐familial spastic paraplegia. No changes were found in homocarnosine level. In one patient with spastic familial paraplegia clear elevation of threonine in the CSF was found. The affected brother showed no such abnormality. CSF homocarnosine elevation is thus no common denominator in familial spastic paraplegi

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1977.tb05636.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThis study has been performed to evaluate slight pareses in patients with multiple sclerosis by means of mechanical endurance experiments. The results are compared with manual grading of pareses in patients and with healthy controls. On average, concordance was found between manual and mechanical estimation but the method is not advantageous for clinical purposes.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1977.tb05637.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY