ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb08018.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT—Moderate doses of cyclophosphamide can cause effects on lymphocytes that may last for some time after discontinuation of the treatment. Since cyclophosphamide is also often used at high doses, we studied the short‐ and long‐term effects of such a high dose (8 grams in 20 days) in 50 patients with chronic progressive multiple sclerosis with the use of monoclonal antibodies. The treatment caused a depletion of lymphocytes, especially CD4+ cells resulting in a significant decrease of the CD4/CD8 ratio. These changes can still be found up to 13.5 years after treatment. Although there was some recovery in the first few years after treatment this was only partial. Therefore, some of the effects of high dose cyclophosphamide on cellular immunity may be permanent. These changes should be taken into account when studying immune parameters or considering new treatments in these pat

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb03702.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT—Two neuro‐Behçet patients have been studied, over a period of several months, by means of peroneal and median somatosensory‐ (SEP), brainstem auditory‐ (BAEP), and visual‐ (VEP) evoked potentials. In both patients, peroneal SEP showed evidence of a pathological reduction in the central conduction velocity without a related deep sensation impairment, while VEP changes were consistent with the visual disorders. Conversely, BAEP and median SEP findings did not show disease‐related abnormalities. The observed anomalies were detectable irrespective of the clinical phase of the disease. Thus, evoked potential assessment is useful in providing objective evidence for evaluating and monitoring CNS damage in neuro‐Beh

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb03703.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT—Computed tomographic features of 7 cases of the late infantile form of MLD confirmed by sural nerve biopsy are presented. Diffuse symmetrical white matter, low attenuation of the cerebral parenchyma was the common feature. Hypodensity of the temporal lobes and the cerebellar hemispheres are 2 features which have not been reported earlier. Three patients had brainstem atrophy without evidence of cerebral atrophy. Awareness of the various CT features of MLD may help in more definitive radiological diagnosis of the disease and to differentiate it from other dysmyelinating diseases of the central nervous syste

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb03704.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT—We present a case of symptomatic hemidystonia of delayed onset. The primary disease was a perinatal, presumed cerebrovascular infarction brought about by febrile illness with convulsions 12 weeks after partus. After many years without neurological symptoms, the hemidystonia started in adolescence, and became stationary after 4 years of mild progression. Magnetic resonance imaging revealed atrophy of the right striatum including the caudate nucleus and putamen. The symptoms responded moderately to treatment with benzhexo

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb03705.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT—The fatty acid (FA) composition of each phospholipid constituent of the red blood cells (RBC) was analyzed, by thin‐layer and gas chromatography techniques, in 61 multiple sclerosis (MS) patients and 61 normal subjects, in whom the plasma lipid FA composition had previously been studied. The MS patients showed a significant decrease in the proportions of linoleic and arachidonic acids in most phospholipids, with a compensatory increase of saturated FA. Correlations between FA percentages in plasma and cell lipids demonstrated abnormalities in the MS patients, suggestive of a disturbance in the exchange between these compartments. The alterations reported in plasma and RBC in the MS patients are consistent with a relative deficiency of essentia

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb03706.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT—Controversy exists in the literature about the significance of primitive reflexes (PR) and extrapyramidal signs (EP) as diffuse cortical dysfunction signs and their relationship to age and cognitive impairment. A sample of 91 patients with a dementia of the Alzheimer type were examined with a standardized technique to assess the relationship between the finding of PR, EP and severity of cognitive impairment measured by Mini‐Mental Status Examination. The value of a short cognitive test, the reflective apraxia (i.e imitation of meaningless gestures), were also assessed. A significantly lower MMS score was correlated with the number of present PR and with presence of snout, sucking and grasping reflexes. No correlation was found between presence or absence of PR and age, depression, or drug therapy. EP score was correlated with the number of present PR and MMS, but not with age. Reflective apraxia score was significantly correlated with the degree of cognitive impairment and was found with lower cognitive impairment than

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb03707.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT—Twenty young adults sustained missile injuries in the Lebanese war. They underwent repeated clinical electroencephalographical (EEG), computerised tomography scanning (CT‐scan) and polysomnographic (PSG) examinations during a 6–year period. All the patients were young adult males with an average age of 23, previously healthy according to their army profiles. Three of 20 developed between 3 to 14 months following injury generalised tonic‐clonic convulsions. The unique common epileptogenic feature characterising the 3 epileptics was the presence of bone fragments in lacerated brain tissue. The possible causal relationship between the presence of the bone fragments and epileptogenesis is di

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb03708.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT—The adenylate kinase (AK) enzyme activity in plasma and CSF of acute brain infarctions was examined. The normal values of enzyme activity in plasma reached from 1.7–5.6 U/l, and in CSF from 0.23–0.71 U/l. According to this present classification a significant CSF increase in AK activity was found with semi‐severe and severe brain infarctions. With the CCT an increased enzyme activity was shown with infarction in or close to the cortex. In no case was an alteration of AK actvity in the serum sample. CSF samples showing blood contamination or pleocytosis led to false pathological results with examination of AK a

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb03709.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT—In a cross‐sectional study of unselected Danish AIDS patients various linear measures of cerebral ventricular size obtained by computed tomography were compared with results of neuropsychological test performances. Third ventricular width as well as right and left septum‐caudate distances were enlarged in the patients (P<0.01). Of 20 patients 15 had at least one abnormal ventricular measurement. Although only one patient was demented, ventricular size correlated inversely with neuropsychological function (r= ‐0.61,P<0.02). The correlation between ventricular size and variation of the reaction time was even closer (r= 0.74,P<0.01). It is concluded that neuroradiological signs of central atrophy often occur in AIDS p

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1989.tb03710.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY