摘要:

Rats with different levels of blood glucose concentration were exposed to 10 min of complete brain ischemia achieved by compression of neck vessels by a pneumatic cuff.All normoglycemic rats survived the ischemic period and made the best clinical recovery. Hyperglycemic rats died within 12 h. Seizure activity was observed in all animals in this group. Three of eight hypo‐glycemic rats died between 3 and 16 days. The clinical recovery was less complete than in the control group.Thus, recovery from cerebral ischemia depends upon preischemic blood glucose concentration. Hyper‐ and hypoglycemia hamper the clinical recovery after transient cerebral ische

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb02855.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb07640.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Four patients with chronic progressive external ophthalmoplegia (c.p.e.o.), retinal, neurological, endocrine and auditory anomalies, three of whom showed signs of cardio‐myopathy, are described. On biochemical examination signs of disturbed pyruvate and lactate metabolism were found and there were indications of loss of respiratory control with loosely coupling of phosphorylation (from oxidation). In the muscle biopsy specimens from all four patients aggregates of abnormal mitochondria were seen, compatible with the diagnosis of a mitochondrial myopathy.A cardiac biopsy was performed once also showing abnormalities.The great similarity in the clinical, biochemical and morphological findings justifies one comprehensive diagnosis. The term “ophthalmoplegia‐plus”, although it has recently fallen into some discredit as a nosological entity, is the most obvious choice.The pathogenesis of ophthalmoplegia‐plus is a widespread general disturbance of mitochondrial function, affecting various organs and systems. This distinguishes it only gradually from true ocular myopathy, and descending ocular myopathy, where only the ocular muscles and skeletal muscles, are affected by the mitochondrial anomaly (at least there is no obvious clinical involvement of other organs). Within the nosological entity of ophthalmoplegia‐plus a subdivision can be made for the Kearns‐Sayre syndrome, in which the clinical picture suggests that the most severe and widespread mitochondrial lesions ar

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb02856.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Sera from 30 patients with acute Guillain‐Barré syndrome were tested for the presence of antibodies to peripheral nerve tissue using the antiglobulin consumption test. An increased binding of IgG was observed in 15 out of 30 sera and in these sera F(ab')2fragments prepared from IgG retained the capacity to combine with peripheral nerve tissue, suggesting an antigen‐antibody interaction. The specificity for peripheral nerve tissue was demonstrated by absorption experiments.F(ab')2fragments prepared from IgG of normal sera, however, failed to react with the tissue, suggesting a non‐specific binding through the Fc part of the molecule. In sera from patients fully recovered from the Guillain‐Barré syndrome and from patients with other neuropathies, no increased binding of IgG was

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb02857.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Twenty Parkinsonian patients and 20 control subjects were compared with respect to their electrooculographic findings. It was found that Parkinsonian patients are distinguished from controls by their significantly lower mean EOG ratios. L‐dopa treatment restored EOG ratios to control values. The findings are interpreted as indicating an association of Parkinson's disease with metabolic changes in the melanin‐containing cells of the pigment epithel

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb02858.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

We have studied the effect of a dietary supplement with linoleic acid (LA) in 76 patients with MS. We could detect no effect of this supplement on the progression of neurological findings, the relapse rate, or the severity of relapses. We were also able to show that oral supplementation with a linoleic acid preparation would raise the blood level of LA in these patients. We were unable to show that there was any reduction in the linoleic acid blood levels associated with acute relapses of MS during this study.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb02859.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Three patients are presented, each showing clinical and electrophysio‐logical findings indicative of the anterior spinal artery syndrome: sudden onset of nonprogressive weakness and spasticity of one or both legs, associated in one patient with pain and in all three patients with selective impairment of temperature sensation, radiological evidence of aortic calcification, normal sensory and motor conduction velocities and normal amplitude of sensory potentials, but diminshed amplitude of evoked motor responses. Electromyography showed widespread fibrillation in muscles of the leg in two patients and evidence of marked loss of motor units in all three patient

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb02860.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

In a double‐blind, double‐matched population survey, the tremor of 12 XYY, 14 XXY, and 52 XY men were studied clinically and by a special tremor recording equipment. XYY men were found to have a more pronounced tremor than XY normals, while XXY men were not found to differ in any definite way from normal XY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb02861.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

An isoquinoline derivative Ro 8–4650 (rac‐4‐(3,4‐dichlorophenyl)‐1,2,3,4‐tetrahydro‐7‐methoxy‐2‐methylisoquinoline hydrochloride) with dopamin‐ergic properties was studied in a randomized crossover trial. The group studied comprised 37 patients with idiopathic parkinsonism and persistent symptoms, despite levodopa treatment. Median Webster rating before allocation was 11.5. The trial drug did not differ significantly from placebo as regards effect and involuntary movements. It led to more frequent minor side effects.Levodopa is not sufficiently effective in all parkinsonians and side effects are frequent. The isoquinoline derivative Ro 8–4650 (rac‐4‐(3,4‐dichlorophenyl)‐1,2,3,4‐tetrahydro‐7‐methoxy‐2‐methylisoquinoline hydrochloride) has shown dopaminergic activity (Haefely1977) and was accordingl

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb02862.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

An isoquinoline derivative Ro 8–4650 (rac‐4‐(3,4‐dichlorophenyl)‐1,2,3,4‐tetrahydro‐7‐methoxy‐2‐methylisoquinoline hydrochloride) with dopamin‐ergic properties was studied in a randomized crossover trial. The group studied comprised 37 patients with idiopathic parkinsonism, not previously treated with levodopa or dopamin agonists.The trial drug was significantly more effective than placebo, but the clinical improvement, according to the Webster rating scale, was small. No significant difference was observed as regards involuntary movements, but the trial drug led to more frequent minor side effects.It can be concluded that the trial drug, despite its proven effect in Parkinson's disease, has only l

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1978.tb02863.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY