摘要:

ABSTRACTThe dispute about whether migraine and cluster headache are one disorder—the “unified theory”—or two facets of a spectrum of “vascular headache” has not yet been settled. the author discusses various clinical features that unite or divide migraine and cluster headache in this respect: so‐called “mixed forms” of vascular headache, corneal indentation pulse amplitudes, partial Horner's syndrome and possible aberrations in histamine metabolism. Evidence is presented showing that there may exist subunits of cluster headache, such as chronic paroxysmal hemicrania (C.P.H.) and a hitherto unreported type that co‐exists with recurring bouts of retrobulbar neuritis and a partial fa

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04787.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTA headache disorder with shortlasting, frequently occurring (6–18/24 hours) head pain attacks is reported. The pain is excruciatingly severe, unilateral (always on the same side), unaccompanied by visual phenomena, nausea/vomiting, hut accompanied by nasal congestien and lacrimation on the symptomatic side. The maximum pain is felt in the temporal region, although during severe attacks the entire hemicranium is involved through the neck, shoulder and homolateral arm in a diffuse way. The attack pattern differs clearly from that of cluster headache both with regard to attack frequency and the long term temporal pattern. In addition to blood and urine parameters and supplementary neurological/neuroradiological investigations, the following parameters were studied: Urinary histamine excretion (partly increased), kinin parameters (occasionally increased blood kinin and reduced blood kininogen), and corneal indentation pulse amplitudes (attack‐induced increase, as in regular cluster headache). The following parameters rendered normal results: prostaglandins, cerebral blood flow, fluorescein appearance time, intrathecal pressure during and between attacks, and muscle biopsy with immunological investigation. The pain attacks can be abolished by continuous indomethacin medication. In spite of the ocular findings i t has in common with cluster headache, this headache seems to differ from cluster heada

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04788.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTIn a retrospective investigation the plasma level of phenytoin (DPH) and phenobarbitone (PB) was studied in 23 epileptics during and outside pregnancy to elucidate the possible influence of pregnancy on drug metabolism, and to correlate changes in seizure frequency to plasma clearance. the plasma clearance was expressed as the ratio between dose in mg per 24 hours, and the plasma level in mg per liter. In all the patients, plasma clearance of DPH increased during pregnancy with interindividual differences. Within a few months after the delivery most patients had DPH plasma clearance in the same range as before pregnancy. the change in PB plasma clearance was insignificant. the increase in seizure frequency seemed to be correlated to the increased DPH plasma clearance. It is therefore recommended that the DPH plasma levels be monitored once a month during pregnancy and after the delivery, until the previous plasma clearance rate is reached, in order to adjust the plasma levels to within the therapeutic range. It might then be possible to prevent the increased seizure frequency which is seen in 45 per cent of pregnant epileptics.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04789.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTA prolonged glucose loading test is described. When used in five patients with familial periodic paralysis it brought them into a state of massive hypopotassaemic paralysis at the first attempt, without the use of exogenous hormone. Three normal persons were subjected to the same glucose loading without exhibiting hypopotassaemia or muscular weakness. There were no essential differences in serum glucose levels between the two groups of individuals. the efficacy of previous methods of inducing paralysis, hormonal as well as non‐hormonal, is reviewed, and the advantages of this new method are pointed ou

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04790.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTIn a double‐blind trial intravenous aminophylline was compared with placebo in 79 patients with acute cerebral infarction. Immediate improvement in the neurological evaluation score was significantly more frequent in patients receiving aminophylline (38 per cent) than in those on placebo (15 per cent); only patients with mild or moderately severe strokes responded to the injection. After 3 weeks, however, the treated patients did not fare significantly better than the controls in terms of neurological score and residual disability. Survival rate, length of stay in hospital, and social readaptation were similar in the two groups. It is concluded that intravenous aminophylline in patients with ischaemic strokes can bring about an immediate symptomatic relief, but without appreciably influencing the ultimate recover

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04791.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe mixed lymphocyte reaction (MLR) as measured by the macrophage electrophoretic mobility (MEM) test is markedly reduced between unrelated multiple sclerosis (MS) patients. This is not the case with other neurological diseases (OND). Within an MS family, the MLR between the propositus and members of the family falls into the low (MS type) range or into the normal or OND range. Those members who give the low results are those who have a MEM‐LAD test result of about 77 per cent, i.e. halfway between that of normal and MS. There is thus a parallelism between the anomalous response to linoleic acid and an unexpectedly low MLR with known MS lymphocytes. Lymphocytes from apparently normal children who have a high (MS‐type) linoleic acid depression result take part in an MLR with MS cells, as if they were themselves true MS cells. Some possible implications these findings may have for the pathogenesis of MS are discus

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04792.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTAs a response to stimulation of the arm nerves an evoked potential can be recorded in the posterior neck region in man. This nuchal evoked potential (NEP) was recorded in three selected patients with A) cervical rib, B) syringomyelia, and C) prolapse of cervical intervertebral disc. Patients A and C had low‐amplitudic NEPs with increased latencies when the affected side was stimulated and “normal” NEPs when the unaffected side was stimulated. Patient B had grossly abnormal, polyphasic NEPs (regardless of the side stimulated) but the simultaneously recorded somatosensory evoked potential was “normal”. No systematic differences in the parameters of the NEP due to different recording locations on the neck could be

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04793.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe incidence of vertebral fractures in 87 epileptic outpatients was 16 per cent. the occurrence of vertebral fractures in epileptics was not correlated to age, state of osteomalacia or to type or number of epileptic seizures.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04794.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThere are various overlaps between migraine and epilepsy and another is suggested here in patients who develop seizures following surgery for intracranial aneurysm. of a group of 37 who had this complication, three with a personal history of migraine and three with a family history of the disorder all developed post‐operative seizure

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04795.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04796.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY