摘要:

A solid‐phase radioimmunoassay method was used for the detection of herpes simplex virus (HSV) immunoglobulin M (IgM), IgA, and IgG antibodies within the central nervous system in 11 adult patients with acute HSV encephalitis. Serial cerebrospinal fluid (CSF) and serum specimens were sampled during the observation periods, extending up to 43 months after onset.The clinical diagnosis of HSV encephalitis was confirmed demonstrating virus or virus antigen in the central nervous system in four patients and with significant HSV antibodies in CSF in all the patients. In acute stage CSF HSV antibodies of a significant level were demonstrated in one of four samples taken on days 3–4 after onset, and in samples taken on days 6–8 in five of nine patients. CSF HSV antibodies of a significant and high level were detected in all samples taken from day 10 after onset.Intrathecal production of HSV IgM and IgA antibodies lasted from 7 weeks to 43 months during the observation periods. All patients had persistent intrathecal production of HSV IgG antibodies as well as of oligoclonal IgG during the total observation periods up to 43 m

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb00781.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Lead exposure may produce varying degrees of neuropsychiatric manifestations from discrete phenomena, quite often seen in children and as an occupational disease, to the rare fulminant lead encephalopathy. It was determined whether or not damage of the blood‐brain barrier permeability in adult rats, as has been demonstrated in neonatal animals exposed to lead, could also play a role. Massive lead exposure did not induce any change in the transfer (facilitated diffusion) of phenylalanine and tyrosine measured by means of the indicator dilution technique. Ultrastructural examination, after application of horseradish peroxidase, did not reveal any pathological changes in the permeability to the tracer. It is concluded that in adult rats, in contrast to neonatal animals, the observed pathological signs clearly seen in the chronically exposed animals must be ascribed to a noxious influence of lead on the extravascular side of the blood‐brain barr

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb00782.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A solid‐phase radioimmunoassay was developed for the detection of glial fibrillary acidic protein (GFAP) and GFAP‐specific immunoglobulin G (IgG) antibodies. In antibody assays purified GFAP was adsorbed onto polystyrene beads, followed by incubation in dilutions of serum.(125‐I)‐labelled human anti‐IgG was used to quantify antibodies bound to solid‐phase GFAP. GFAP in samples was measured by the inhibition of the binding of anti‐GFAP antibody to solid‐phase GFAP.The serum and CSF samples of 19 brain tumor, 40 multiple sclerosis and 66 control patients were assayed for anti‐GFAP antibodies. The binding values in the serum and CSF samples of the brain tumor patient group were higher and the binding values in the CSF samples of the multiple sclerosis group lower than those of the control group. The differences were statisti

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb00783.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Paired cerebral blood flow measurements at 2 levels of arterial carbon dioxide tension (PaCO2) were made in 10 subjects with an elevated haematocrit and blood viscosity. A value of 32 was obtained for the percentage change in flow per kPa change inPaCO2(CO2reactivity). The haematocrit was then lowered by venesection from 0.536 to 0.458 and the measurements were repeated. The post‐venesectionCO2reactivity was 29, which was not significantly different from the pre‐venesection value. ThusCO2reactivity is not comprised in patients with low cerebral blood flow secondary to an elevated haematoc

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb00784.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The importance of accurate diagnosis of epileptic manifestations, even if unusual, as complications of diagnostic metrizamide exploration of the CSF space is emphasized on the basis of 2 case histories.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb00785.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Studies of post‐lesional reorganization of central nervous connections have shown that central nerve fibers respond to nearby denervation by sprouting and formation of new terminals. The connections in the central nervous system (CNS) are accordingly much more plastic than was thought for a long time. This has revived the interest intransplantationof central nervous tissue. In this study we present some historical data on CNS transplantation supplemented by recent results obtained in our laboratory. Pieces of hippocampal tissue from embryonic or early postnatal rats were transplanted to different parts of the brain of littermates or adult rats. About two‐thirds of the transplants were recovered after survival times ranging from 4 d to 2 years, and their cytological organization and intrinsic connections were monitored by cell and fiber stains and histochemical methods (AChE staining and Timm sulphide silver method). Comparison with both a normal and a lesioned control material revealed that in most transplants the tissue had developed as it does when leftin situin the donor brain, but deprived of its major afferent connections. In several instances we found evidence of a major exchange of connections between the transplants and host brains. The conditions needed for this to occur appeared to involve growth stimulation of host brain fibers by transection (host to transplant) and denervation of host neuropil (transplant to host). In cases where these conditions are met, the use of transplants may have future implications in attempts to repair lesions in the central nervous syst

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb00786.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Books review in this article:The suppression of experimental allergic encephalomyelitis and multiple sclerosis. Ed. byA. N. Davison&M. L. Cuzner.Neurotransmitters. Comparative aspects. Ed. byJ. Salanki&T. M. Turpaev.Neurobiology of cerebrospinal fluid. Vol. 1. Ed. byJ. H. Wood.The management of pain. Ed. Beks, J. W. F. Excerpta

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1981.tb00787.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY