摘要:

EEG and psychometric findings were studied in a group of 57 patients consisting of 19 cases of Alzheimer's disease, 7 cases of Pick's disease, 24 cases of cerebrovascular dementia (CVD) and a group of 7 cases with dementia of various other etiology. The diagnoses have so far been confirmed by autopsy in 23 out of 57 cases. EEG was evaluated by means of visual inspection. Psychometric studies enabled a classification into 5 psychometric defect groups according to the degree of dementia. An overall good correlation was found between the degree of dementia and EEG abnormality. A significant correlation between the test score and the EEG was found only for the vocabulary test and paired associates test. However, on the reaction time test, color word test, and Koh's block design test, large patient groups were untestable, and a highly significant correlation was found between non‐testability and severely abnormal EEG. The Alzheimer and the CVD groups differed distinctly, most of the Alzheimer cases showing a severe or moderate degree of EEG abnormality and dementia, whereas in the CVD cases, the dementia was less pronounced and the EEG often normal or only slightly abnormal. Four out of seven cases of Pick's disease had a normal EEG, which distinguished them from the Alzheimer cases which had a comparable psychometric defec

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02933.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The measles‐adherent phenomenon described byLevyin multiple sclerosis was investigated by studying the rosetting effect of blood lymphocytes from multiple sclerosis patients and healthy controls on chronically measles infected heteroploid Hela cells (Lu 106). No significant difference in rosetting was observed, irrespective if a lymphocyte/virus infected Lu cell ratio of 10/1 or 50/1 was used. Therefore, the test is not discriminative for multiple sclerosi

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02934.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Offspring from methadone‐treated Wistar rats (last trimester of pregnancy), as compared toad liband pair fed controls, showed a reduction of body growth which continued throughout the 28‐day period during which animals were observed after birth. Brain growth, as indicated by weight, cortical thickness and number of cells in the neocortex also showed a reduction in growth, which was apparent only during the first 14 days, after which there were no differences between the groups. However, in the hippocampus, neuronal density changes/unit area continued throughout the 28‐day period in the methadone exposed group and to a lesser extent in the PF group suggesting that this area of brain did not return to normal dimensions or degree of maturation by the end of the third week.Since it has been suggested that any deficit in growth associated with prenatal methadone‐exposure might be due to a reduction in food intake, a group pair‐fed to the amount of food consumed by the methadone group was included in the study. Generally, the data from the PF group was intermediate between that obtained from thead libfed controls and the methadone‐exposed animals. Thus, while some of the growth reduction observed in the methadone‐exposed pups could have been due to the impaired nutritional status of their mothers during the last third of pregnancy, a part of the reduced growth must be attributed to the drug treatment, since the reduced growth exceeded that observed in the p

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02935.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Duchenne muscular dystrophy (DMD) is a disorder whose pathogenesis is attributed, according to the most recent theories, to generalized membrane abnormalities, including red cell membrane. The study of erythrocyte ghosts in patients affected by DMD showed alterations in ion transport and in various enzymatic activities.Employing a spectrofluorometric method using 1‐anilino‐8‐naphthalene sufonate (1.8‐ANS) we have tried to characterize the erythrocyte ghosts of DMD patients, definite DMD carriers and normal controls, matched for age and sex. We found an increase of membrane polarity in DMD and definite DMD‐carrier erythrocyte ghosts.Using this new method we were able to:‐ confirm by means of a different technique the previous observations of many authors on erythrocyte ghost alterations in DMD‐ find a new technique useful in detecting the DMD carriers. It is note‐worthy that in such a way the detection rate of definite DMD carriers was higher than wi

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02936.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The etiology of cerebrovascular thrombosis in normotensives has not been elucidated.This controlled retrospective study examines the association between alcoholism and cerebrovascular thrombosis in patients under age 50. The hospital records of 49 patients under age 50 with a diagnosis of cerebrovascular thrombosis without hypertension were reviewed for possible predisposing factors. Alcohol abuse is the one common denominator among the males in the study.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02937.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Experimental portal‐systemic shunting is accompanied by a reduction of the soluble brain proteins. Isoelectric focusing does not indicate any selective decrease of one particular protein or group of proteins. The reduction persists with sustained shunting. The interference with brain protein metabolism is compatible with a grossly normal behavior, alterness and locomotio

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02938.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY