摘要:

The neuropathic profile was studied in 26 patients with long‐standing, insulin‐dependent diabetes mellitus and end‐stage nephropathy using tests to evaluate large and small nerve fibres and autonomic function. Clinically, 18 patients (69%) has symptoms and signs of peripheral neuropathy, 9 (35%) had symptoms of autonomic involvement. Vibratory sensation was impaired in 20 patients (77%) in the lower limbs and in 6 (22%) in the upper limbs; cold and warm sensation was equally often impaired in the feet and in the hands with no significant difference between patients with and without neuropathy. Hearth rate variation was abnormal in 23 patients at rest (88%), in 24 (92%) during deep breathing and during the orthostatic test. Conduction studies revealed abnormalities in two or more nerves in all patients regardless of whether or not they had overt neuropathy clinically. Thus, the applied multimodal tests revealed evidence of impaired function in large or small nerve fibres or both in all patients independent of clinical fin

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb02671.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

From a series of 26 diabetics selected for combined pancreas and kidney transplantations 9 died before surgery was scheduled, one died after surgery and 4 rejected the transplants. The effect of pancreas or kidney transplantation or both on vibratory perception and thermal thresholds, various motor and sensory conduction parameters were studied in 9 of the remaining 12 patients. In 6 both the pancreatic and renal grafts were functioning, in 2 the pancreas was rejected, and in 1 the kidney. At an average follow‐up of 41 months after surgery, the mean total score of clinical and electrophysiological improvement in 6 patients with successful combined transplantation was 5.5±1.6 compared with – 4.3±2.5 in 3 patients with one surviving transplant (P<0.001). Similarly, the average increase in nerve conduction velocity was 5.8±1.1 m/s in patients with two functioning grafts whereas it decreased 2.9±0.7 m/s in those with only one (P<0.001). The quality of life was considered improved in patients with successful outcome of the two organ transplantations in contrast to the statements of those with o

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb02672.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb08109.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb08104.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb08110.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb08096.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb08111.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb08112.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb08097.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1994.tb08105.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY