摘要:

The present study was devoted to an immunochemical elucidation of antigenic similarities and differences between cytoplasmic and microsomal fractions of six multiple sclerosis (MS) and seven non‐MS brain autopsy specimens. The antigenic composition of the samples studied was traced by crossed immunoelectrophoresis using antibodies made by immunization of rabbits with the corresponding fraction. The following data were obtained:1.A measles antigen (defined as an antigen formed in vero cells during measles infection) and two specific antigens have been purified more than 3000‐fold from MS brains by means of molecular filtration and DEAE cellulose chromatography.2.All three antigens have a molecular weight between 105–106 daltons and isoelectric points between 3.5–6.0.3.Measles antigen has also been found in three out of seven non‐MS brains, however, it did not stimulate antibody formation in rabbits in contrast to measles antigen of MS brain.The significance of the above‐mentioned data is discussed in view of the immunological abnormalities previously found in MS patients. It cannot be excluded that the antigens found represents one or more vir

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02939.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The HLA antigens B7 and Dw2 occurred at elevated frequencies in 105 multiple sclerosis (MS) patients (49 and 47%, respectively), compared to healthy controls (29 and 30%), especially in MS patients with oligoclonal CSF‐IgG (51 and 50%), in cases with CSF‐IgG index values above 1.5 (64 and 64%), and in those with the most malignant course of the disease (47 and 59%). Normal or only slightly elevated frequencies of B7 and Dw2 were found in MS patients without oligoclonal CSF IgG (35 and 29%), normal CSF‐IgG index (43 and 39%), and the most benign course (42 and 37%). No correlation was found between the HLA type and measles virus antibody titers in serum or a measles virus antibody response within th

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02940.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The mode of action of dantrolene sodium was studied in 11 multiple sclerosis patients with spastic paresis of the legs by measurements of changes in electromyographic and mechanomyographic proprioceptive reflex responses and in voluntary power. Dantrolene sodium 0.5 mg per kg body weight given intravenously clearly reduced monosynaptic reflex twitch tension, but voluntary power only moderately so. The electromyographic reflex responses were unchanged or slightly increased. The mode of action of the drug on spindle function is discussed on the basis of the present findings and the literature. It is concluded that dantrolene sodium does not reduce spindle stretch sensitivity, but probably reduces activity in group II and tonic 1a afferent fibers.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02941.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

An easy and safe method for muscle biopsy is described. The biopsy instrument is an alligator forceps (Weil‐Blakesley's conchotome). With this method an adequate amount of muscle tissue can be obtained for both chemical and morphological studies. The method combines the advantage of the “open‐surgical” method‐sufficient quantity of material‐with the advantages of the needle methods‐easy to perform, not incapacitating and only slightly uncomfortable for the patient. Out of 959 consecutive biopsies with this method only 19 were impossible to evaluate because of too much artefact or too

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02942.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Cerebral asthenopia is often overlooked as a symptom in diffuse brain lesion. An objective correlate of this symptom has so far never been demonstrated. Averaged visual evoked potential (VEP) in 10 patients with asthenopia was compared with 20 normal subjects. Both eyes and each eye alone were stimulated using bipolar recording in the midline and over each of the occipital lobes. There was no difference of latency of the VEPs in the two groups, but the amplitude of the most prominent component was significantly reduced in the patients. There was also a difference in the two groups regarding habituation and lateralisation. No amplitude difference could be found in the somatosensory evoked potential. The amplitude difference in VEP, as an objective correlate of asthenopia, is probably modal specific and suggests involvement of the visual cortex. VEP is unsuitable as a diagnostic tool due to the great overlap between amplitudes in asthenopic patients and control subjects.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02943.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Frequency of pigmentary degeneration of the retina (PDR) among patients with degenerative and heredodegenerative neurological diseases (HDNDs) was estimated based on the hospital statistics. PDR was detected in 3% of 176 inpatients with HDNDs by careful ophthalmologic examination. On the other hand, out of 30 consecutive cases of PDR seen in our Department of Neurology, 15 patients were associated with some form of HDNDs. Atypical PDR were more frequently associated with HDNDs than typical PDR. Among neurological manifestations in those 15 cases of PDR associated with HDNDs, mental deficiency, hearing disturbance, spasticity, progressive ophthalmoplegia and ataxia were most frequently encountered. Four cases with unusual symptomatology were presented. Clinical analysis of cases of PDR associated with HDNDs in the present series as well as in the relevant literature revealed an extreme variety of clinical manifestations and underlying metabolic disorders, suggesting a possible participation of multiple factors in the pathogenesis of PDR. Importance of careful ophthalmologic examination in HDNDs was stressed from the prognostic point of view.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02944.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Book Review in this ArticleJ. Z. Young: Programs of the Brain.Music and the brain ‐ Studies in the neurology of music.Norman E. Spear: The Processing of Memories: Forgetting and Retentio

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1979.tb02945.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY