摘要:

ABSTRACTIn 4 patients with subarachnoid haemorrhage after ruptured intracranial aneurysm, tranexamic acid (AMCA) was used to prevent the recurrence of the bleeding. 1000 mg of AMCA was given intravenously 6 times a day for 8 days. The fibrinolytic activity of blood and spinal fluid was measured simultaneously with the etermination of AMCA levels before and after the beginning of treatment. The fibrin plate method showed no fibrinolytic activity in plasma or in CSF. Local fibriolysis was demonstrated by the presence of fibrin degradation products in spinal fluid. After repeated administration, AMCA crossed the blood‐brain barrier and effectively inhibited the local fibrinolysis within the spinal fluid. The findings in this study suggest that in patients with subarachnoid haemorrhage AMCA should be aministrated intravenously in a dosage of 15–20 mg/kg body weight 6 times a day as soon as possible after the bleeding. But treatment with the antifibrinolytic drug does not change the indication for surgical ther

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07561.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACTThe fibrinolytic activity of the peripheral blood and cerebrospinal fluid was studied in 10 dogs in which intracerebral haematomas had been produced by injection of blood into the brain. Blood and cerebrospinal fluid samples were obtained at regular intervals before and after operation. The fibrinolytic activity of these two fluids were estimated by the fibrin plate method and by assays for fibrin degradation products. After the production of the haematoma, signs of increased fibrinolytic activity were found in blood and cerebrospinal fluid one day after the intracerebral injection in 6 animals. A correlation was found between the size of the haematoma and the level of the fibrinolytic activity of blood and cerebrospinal fluid. Determination of fibrin degradation products in blood and cerebrospinal fluid and the measurement of fibrinolytic activity by the plate method complement each other and are therefore recommended in this type of investigation.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07562.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACTElectroencephalographic changes similar to those seen in the subacute stage of Jakob‐Creutzfeldt disease were observed in two comatose patients surviving 1 and 3 months respectively after a period of transient cerebral ischemia caused by cardiac arrest. Neuropathological examination revealed severe neuronal changes, status spongiosus and gliosis of cerebral and cerebellar cortex and of basal ganglia. The distribution and character of the lesions closely resembled those known to occur in subacute cases of Jakob‐Creutzfeldt disease. The rhythmical EEG changes characteristic of the subacute stage of Jakob‐Creutzfeldt disease diminish in the terminal stage of this disorder, and this type of activity has not been seen in more severe cases of ischemic brain injury. These EEG changes, therefore, may be related to the degree of the corresponding morphological brain lesions and not to their eti

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07563.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACTSerum levels of FSH, LH, TSH, and GH were studied in 17 parkinsonian patients before treatment with L‐DOPA and in 25 patients during treatment with L‐DOPA. A radioimmunosorbent technique was used. With few exceptions the hormone levels were normal in the non‐treated patients. No statistically significant differences between the treated and non‐treated patients wer

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07564.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACTThis study deals primarily with the new type of renal papillary necrosis which appeared during the 1950's and which was explained by the excessive use of phenacetin‐containing analgesics. It was observed that many of the patients used the analgesic compound because of their migraine and/or tension headaches. The clinical analysis of 95 migraine patients has given the following results: 1. migraine patients abused or overconsumed phenacetin. 2. 6 migraine patients did not at all use analgesics and 8 patients took very small doses. None of them showed signs of diabetes or urinary tract obstruction. 3. The migraine headache is usually of a grave character and classified as classical migraine in 2/3 of the cases. 4. Psychasthenic personalities dominate. 5. Peptic ulcers, mainly duodenal ulcers, occur more frequently than in a ‘normal’ population and are much more common than in other migraine material. 6. Hyperthyroidism is much more common than in a ‘normal’ population. 7. Allergy, including asthma, is much more common than in a ‘normal’ population. 8. Nearly 1/4 of the migraine‐patients suffer from peripheral vascular disturbances (cold

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07565.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACTThe surgical treatment of intracranial aneurysms with subarachnoid bleeding is beset with difficulties if the operation is performed at the acute or subacute stage. Cerebral oedema and vascular spasm increase the risk, and it has been found essential to carry out the operation at an optimal time with regard to the cerebral circulation. The latter can be determined with the aid of the intravenous isotope indicator technique, which gives information about cerebral blood flow and mean transit time. The reliability of the calculations regarding cerebral flow has been tested through comparison with the Xenon wash‐out method. The two methods correspond well; the coefficient of variation was about 15% at moderately disturbed circulation. This finding confirms the importance of the simple and easily repeated intravenous isotope techniqu

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07566.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACTComplement fixing antibrain antibodies were found in cerebrospinal fluid (CSF) from 6 of 12 patients with multiple sclerosis (MS), but not in any of 17 CSF specimens from patients with other neurological disorders when tested with a crude MS brain preparation as antigen. Complement fixing antibrain antibodies in lower titres were also found in 5 of the 6 positive MS CSF specimens when tested with a control brain preparation as antigen. The findings indicate the occurrence in MS of an immunization against brain components.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07567.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The lower stimulation threshold of the adrenals was determined in 104 patients suffering from multiple sclerosis. In another series of patients the effect of insulin induced stress (hypoglycaemia) was surveyed. There was no correlation between the functional state of the adrenals as revealed by the tests and the efficacy of treatment with Cortrosyn. A study comparing the effect of the infusion with physiological doses and the effects of the usually administered therapeutic doses has led to a preference for the first method in the treatment of rapidly progressing cases and for the rapid reduction of functional disturbances linked with organic lesions.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07568.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACTSix autopsied cases of rare cerebrovascular diseases of childhood have been presented, including arteriosclerosis, alternating hemiparesis (“moyamoya” syndrome), phyototic aneurysm caused by an awn of grass, arterio‐occlusive infarct occurring near the time of birth, necrotizing arteritis predominantly affecting the nervous system and infantile thrombosis with cerebral infarction associated with tuberous sclerosis. These cases have raised some important but difficult questions with regard to the pathogenesis of strokes during childhood as compared to adulthood, especially whether cerebral arteriosclerosis is a response to diverse injuries during childhood and young adulthood, and whether there is a factor which protects the cerebral arteries during infancy and childhood such that the systemic arteries bear the brunt of vascular disease as compared to adulthood. In addition, a reasonable classification of cerebral arterial diseases during childhood (based on tissue diagnoses) is presented and disc

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07569.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACTA 19‐year‐old woman presented with internal ophthalmoplegia, dryness of mouth, ileus, bladder paralysis and anhidrosis. She had an incomplete recovery in 28 months. Clinical and pharmacological examination showed impairment of peripheral autonomic functions governed by cholinergic parasympathetic and sympathetic nerves, probably caused by an impaired synthesis or release of acetylcholine in post‐ganglionary autonomic nerves. Electron microscopy revealed no abnormality of skin nerve fibres. The site of the lesion resembles that seen in some cases of botulism, but the protracted course of the present case is unique. Its etiology remains ob

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1972.tb07570.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY