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1. |
Development of myoclonus in patients with partial epilepsy during treatment with vigabatrin: an electroencephalographic study |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 1-5
M. G. Marciani,
M. Maschio,
F. Spanedda,
C. Iani,
G. L. Gigli,
G. Bernardi,
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摘要:
In the context of a study of the effects of γ‐vinyl‐GABA (GVG) on seizure occurrence and on EEG abnormalities we present three cases with focal epilepsy in which new clinical and EEG paroxysmal manifestations were observed during GVG therapy. At that time, whereas an amelioration or no change in patients' habitual seizures were observed, myoclonic jerks appeared with related changes in the EEG paroxysmal abnormalities, represented by generalized polyspike and wave complexes. An electroclinical correlation was recorded in one case. These data indicate that, although occurring rarely, it is possible to have epileptic myoclonus during GVG treatment. Mechanisms underlying these manifestations are difficult to explain. Probably a shift in the anti/proconvulsant GABAergic balance towards the latter may compromise the therapeutic effect of
ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb05834.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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2. |
Preface |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 3-3
Henrik B. W. Larsson,
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ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb08120.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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3. |
List of papers |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 5-5
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ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb08131.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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4. |
Early onset Alzheimer's disease in a South American pedigree from Argentina |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 6-13
C. A. Mangone,
E. M. Castaño,
E. Levy,
G. Abiusi,
T. Wisniewski,
M. R. Marques,
E. Faccio,
P. B. Gorelick,
B. Frangione,
R. E. P. Sica,
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摘要:
We report the clinical, SPET, immunohistochemical and DNA features of an early‐onset familial Alzheimer's disease (FAD) in an Argentine pedigree of South American indian ethnic background. Pedigree spans 5 generations comprising more than 110 biological relatives. Clinical data supported the diagnosis of early onset FAD (mean age at onset 38.9 years) in 10 family members, including 3 with pathological confirmation (mean age at death 48.5). The pattern of transmission suggested autosomal dominant inheritance. Prominent features were mood changes, early language impairment, myoclonus, seizures and cerebellar signs. SPET displayed bilateral frontal, temporo‐parietal and cerebellar hypoperfusion in early stages and in an asymptomatic member at risk, suggesting that SPET may have predictive value in this family. Immunohistochemistry showed β amyloid deposits within neuritic plaques and vessel walls and no anti‐PrP immunoreactivity. DNA analysis showed no abnormalities in the β amyloid precursor protein gene. The identification of additional genetic defects in well characterized independent FAD pedigrees will contribute to the understanding of the pathogenesis of Alzheimer's
ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb05835.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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5. |
Introduction |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 7-8
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ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb08133.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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6. |
Intracerebral Neural Transplantation |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 8-11
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ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb08134.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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7. |
The general pathology of the multiple sclerosis plaque |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 9-10
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ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb08122.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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8. |
Materials and methods |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 11-14
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ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb08135.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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9. |
Autonomic dysfunction in Alzheimer's disease |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 14-18
A. Algotsson,
M. Viitanen,
B. Winblad,
G. Solders,
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摘要:
Twenty‐nine patients fitting the NINCDS‐ADRDA criteria of Alzheimer's disease participated in a study of autonomic functions. A number of tests on parasympathetic and sympathetic functions were made. Eighteen of the patients were tested a second time one year later. Fifteen healthy subjects with no family history of dementia disorders served as controls. Compared to the controls, the patients showed signs suggesting autonomic dysfunction affecting parasympathetic, as well as vasomotor sympathetic, functi
ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb05836.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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10. |
T1and T2measurements in MS plaques and white matter |
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Acta Neurologica Scandinavica,
Volume 91,
Issue 1,
1995,
Page 15-25
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ISSN:0001-6314
DOI:10.1111/j.1600-0404.1995.tb08124.x
出版商:Blackwell Publishing Ltd
年代:1995
数据来源: WILEY
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